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• W4386910082 abstract "Abstract Background The aim of the study was to determine the potential of a low-fat diet (LFD) to protect against oxidative and inflammatory damage in the course of asthma and obesity when combined with antioxidants (alpha-lipoic acid–ALA, apocynin–APO) or a probiotic (P) ( Lactobacillus casei ). Methods The experiments were carried out on ten groups of male C57/BL6 mice that were fed standard fat (SFD), low-fat (LFD), or high-fat (HFD) diets. Ovalbumin (OVA, administered subcutaneously and by inhalation) was used to sensitize the animals. IL-1α, IL-10, eotaxin-1, leptin, and TNF-α concentrations were examined in blood, while total glutathione (GSHt), reduced glutathione (GSH), oxidized glutathione (GSSG) and –SH groups were measured in lung homogenates. Results LFD in combination with the analyzed compounds (APO, P, ALA) significantly decreased the concentration of IL-1α compared to the OVA + HFD group ( p < 0.01; p = 0.025; p = 0.002, respectively). Similarly, the treated mice demonstrated lower eotaxin-1 concentrations compared to the HFD group ( p < 0.001). Moreover, supplementation of LFD with probiotics significantly increased the concentration of IL-10 vs. controls ( p < 0.001) and vs. untreated OVA-sensitized and challenged/obese mice ( p < 0.001). Animals administered APO/ALA with LFD displayed a significant decrease in TNF-α concentration compared to OVA + HFD mice ( p = 0.013; p = 0.002 respectively). Those treated with ALA displayed significantly improved GSH levels ( p = 0.035) compared to OVA + HFD mice. Conclusions Supplementation of the tested compounds with LFD appears to have a positive influence on the glutathione redox status of pulmonary tissues and selected inflammatory parameters in mouse blood." @default.
• W4386910082 created "2023-09-22" @default.
• W4386910082 creator A5039000318 @default.
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• W4386910082 date "2023-09-21" @default.
• W4386910082 modified "2023-10-17" @default.
• W4386910082 title "Alpha-lipoic acid, apocynin or probiotics influence glutathione status and selected inflammatory parameters in C57/BL6 mice when combined with a low-fat diet" @default.
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• W4386910082 doi "https://doi.org/10.1007/s43440-023-00527-8" @default.
• W4386910082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37730940" @default.
• W4386910082 hasPublicationYear "2023" @default.
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