Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386910376> ?p ?o ?g. }
- W4386910376 endingPage "1793" @default.
- W4386910376 startingPage "1751" @default.
- W4386910376 abstract "Emodin is a natural compound found in several traditional Chinese medicines, including Rheum palmatum and Polygonum cuspidatum. Recent studies have shown that emodin exhibits potent anticancer effects against a variety of cancer types, including liver, breast, lung, and colon cancer. Emodin's anticancer effects are mediated through several mechanisms, including inhibition of cell proliferation, induction of apoptosis, and suppression of tumor angiogenesis and metastasis. In this review, we provide an overview of recent research progress and new perspectives on emodin's anticancer effect. We summarize the current understanding of the molecular mechanisms underlying emodin's anticancer activity, including its effects on signaling pathways such as the PI3K/Akt, MAPK, and NF-[Formula: see text]B pathways. We also discuss the potential of emodin as a therapeutic agent for cancer treatment, including its use in combination with conventional chemotherapeutic drugs and as a sensitizer for radiotherapy. Furthermore, we highlight recent advances in the development of emodin derivatives and their potential as novel anticancer agents. Finally, we discuss the challenges and opportunities for the translation of emodin's anticancer properties into clinical applications, including the need for further preclinical and clinical studies to evaluate its safety and efficacy. In conclusion, emodin represents a promising natural compound with potent anticancer properties, and its potential as a therapeutic agent for cancer treatment warrants further investigation. This review provides a comprehensive overview of the current research progress and new perspectives on emodin's anticancer effects, which may facilitate the development of novel therapeutic strategies for cancer treatment." @default.
- W4386910376 created "2023-09-22" @default.
- W4386910376 creator A5006452874 @default.
- W4386910376 creator A5008171804 @default.
- W4386910376 creator A5027700772 @default.
- W4386910376 creator A5043067285 @default.
- W4386910376 creator A5047581480 @default.
- W4386910376 creator A5059379194 @default.
- W4386910376 creator A5072769748 @default.
- W4386910376 creator A5090837482 @default.
- W4386910376 date "2023-01-01" @default.
- W4386910376 modified "2023-10-12" @default.
- W4386910376 title "Research Progress and New Perspectives of Anticancer Effects of Emodin" @default.
- W4386910376 cites W1107917109 @default.
- W4386910376 cites W1495287184 @default.
- W4386910376 cites W1531592568 @default.
- W4386910376 cites W1533021978 @default.
- W4386910376 cites W1897257409 @default.
- W4386910376 cites W1964147288 @default.
- W4386910376 cites W1964392067 @default.
- W4386910376 cites W1966361767 @default.
- W4386910376 cites W1966454844 @default.
- W4386910376 cites W1968618444 @default.
- W4386910376 cites W1969900704 @default.
- W4386910376 cites W1971039052 @default.
- W4386910376 cites W1973251202 @default.
- W4386910376 cites W1975380979 @default.
- W4386910376 cites W1975490334 @default.
- W4386910376 cites W1982146445 @default.
- W4386910376 cites W1982976853 @default.
- W4386910376 cites W1984230913 @default.
- W4386910376 cites W1993223771 @default.
- W4386910376 cites W1996694532 @default.
- W4386910376 cites W1998166046 @default.
- W4386910376 cites W1998270878 @default.
- W4386910376 cites W2000733366 @default.
- W4386910376 cites W2003601985 @default.
- W4386910376 cites W2006478722 @default.
- W4386910376 cites W2007086998 @default.
- W4386910376 cites W2007456673 @default.
- W4386910376 cites W2013632563 @default.
- W4386910376 cites W2014436209 @default.
- W4386910376 cites W2019990104 @default.
- W4386910376 cites W2022197547 @default.
- W4386910376 cites W2024652332 @default.
- W4386910376 cites W2028544780 @default.
- W4386910376 cites W2030026017 @default.
- W4386910376 cites W2032672604 @default.
- W4386910376 cites W2035227451 @default.
- W4386910376 cites W2039220450 @default.
- W4386910376 cites W2041364725 @default.
- W4386910376 cites W2044734375 @default.
- W4386910376 cites W2048023428 @default.
- W4386910376 cites W2049881247 @default.
- W4386910376 cites W2050994370 @default.
- W4386910376 cites W2054236546 @default.
- W4386910376 cites W2054406526 @default.
- W4386910376 cites W2054492655 @default.
- W4386910376 cites W2055904567 @default.
- W4386910376 cites W2063024925 @default.
- W4386910376 cites W2065175848 @default.
- W4386910376 cites W2065736143 @default.
- W4386910376 cites W2069412624 @default.
- W4386910376 cites W2069537618 @default.
- W4386910376 cites W2074794891 @default.
- W4386910376 cites W2078730594 @default.
- W4386910376 cites W2081107312 @default.
- W4386910376 cites W2082055657 @default.
- W4386910376 cites W2085661888 @default.
- W4386910376 cites W2092271963 @default.
- W4386910376 cites W2092667428 @default.
- W4386910376 cites W2093713702 @default.
- W4386910376 cites W2101740921 @default.
- W4386910376 cites W2101970481 @default.
- W4386910376 cites W2103724828 @default.
- W4386910376 cites W2103916795 @default.
- W4386910376 cites W2104236657 @default.
- W4386910376 cites W2106426729 @default.
- W4386910376 cites W2119130730 @default.
- W4386910376 cites W2121796754 @default.
- W4386910376 cites W2123387025 @default.
- W4386910376 cites W2125340885 @default.
- W4386910376 cites W2125689880 @default.
- W4386910376 cites W2137029911 @default.
- W4386910376 cites W2141701042 @default.
- W4386910376 cites W2142518692 @default.
- W4386910376 cites W2144206630 @default.
- W4386910376 cites W2158862003 @default.
- W4386910376 cites W2159408514 @default.
- W4386910376 cites W2160234260 @default.
- W4386910376 cites W2160368262 @default.
- W4386910376 cites W2163217325 @default.
- W4386910376 cites W2164858484 @default.
- W4386910376 cites W2170630678 @default.
- W4386910376 cites W2172140039 @default.
- W4386910376 cites W2212021512 @default.
- W4386910376 cites W2226395511 @default.
- W4386910376 cites W2268492365 @default.