Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386912953> ?p ?o ?g. }
- W4386912953 endingPage "4663" @default.
- W4386912953 startingPage "4663" @default.
- W4386912953 abstract "(1) Background: This study investigated whether polo-like kinase 4 (PLK4) is a suitable therapeutic target or biomarker for lung adenocarcinoma (LUAD). (2) Methods: We acquired LUAD data from The Cancer Genome Atlas (TCGA) database through the UCSC Xena data portal. Gene expression, clinical, survival, and mutation data from multiple samples were analyzed. Gene enrichment analysis, unsupervised clustering of PLK4-related pathways, and differential gene expression analyses were performed. Additionally, correlations, t-tests, survival analyses, and statistical analyses were performed. (3) Results: PLK4 expression was higher in LUAD tissues than in normal tissues and was associated with poor prognosis for both overall and progression-free survival in LUAD. PLK4 was highly correlated with cell-proliferation-related pathways using Gene Ontology (GO) biological process terms. PLK4 expression and pathways that were highly correlated with PLK4 expression levels were upregulated in patients with LUAD with the TP53 mutation. (4) Conclusions: PLK4 expression affects the survival of patients with LUAD and is a potential therapeutic target for LUAD with TP53 mutations." @default.
- W4386912953 created "2023-09-22" @default.
- W4386912953 creator A5001886761 @default.
- W4386912953 creator A5005217399 @default.
- W4386912953 creator A5006291712 @default.
- W4386912953 creator A5011980528 @default.
- W4386912953 creator A5014023648 @default.
- W4386912953 creator A5018069766 @default.
- W4386912953 creator A5018385660 @default.
- W4386912953 creator A5022124273 @default.
- W4386912953 creator A5026018607 @default.
- W4386912953 creator A5035994144 @default.
- W4386912953 creator A5036440273 @default.
- W4386912953 creator A5036720036 @default.
- W4386912953 creator A5038973475 @default.
- W4386912953 creator A5040715104 @default.
- W4386912953 creator A5060557396 @default.
- W4386912953 creator A5061814504 @default.
- W4386912953 creator A5064697305 @default.
- W4386912953 creator A5072589626 @default.
- W4386912953 date "2023-09-21" @default.
- W4386912953 modified "2023-10-17" @default.
- W4386912953 title "Polo-like Kinase 4: A Multifaceted Marker Linking Tumor Aggressiveness and Unfavorable Prognosis, and Insights into Therapeutic Strategies" @default.
- W4386912953 cites W1576436685 @default.
- W4386912953 cites W1658218471 @default.
- W4386912953 cites W1977721021 @default.
- W4386912953 cites W1979566241 @default.
- W4386912953 cites W2022031287 @default.
- W4386912953 cites W2064580048 @default.
- W4386912953 cites W2113256958 @default.
- W4386912953 cites W2131876608 @default.
- W4386912953 cites W2139236349 @default.
- W4386912953 cites W2288903023 @default.
- W4386912953 cites W2296569938 @default.
- W4386912953 cites W2794804602 @default.
- W4386912953 cites W2913214055 @default.
- W4386912953 cites W2946050032 @default.
- W4386912953 cites W2982482833 @default.
- W4386912953 cites W3040614315 @default.
- W4386912953 cites W3046931490 @default.
- W4386912953 cites W3093280293 @default.
- W4386912953 cites W3107452708 @default.
- W4386912953 cites W3128227583 @default.
- W4386912953 cites W3136825371 @default.
- W4386912953 cites W3188049662 @default.
- W4386912953 cites W3206449202 @default.
- W4386912953 cites W3209104889 @default.
- W4386912953 cites W4205097549 @default.
- W4386912953 cites W4206841660 @default.
- W4386912953 cites W4221076981 @default.
- W4386912953 cites W4223539621 @default.
- W4386912953 cites W4281999127 @default.
- W4386912953 cites W4296493376 @default.
- W4386912953 cites W4296736483 @default.
- W4386912953 cites W4306156121 @default.
- W4386912953 cites W4312187766 @default.
- W4386912953 cites W4315754639 @default.
- W4386912953 cites W4318702003 @default.
- W4386912953 cites W4327894154 @default.
- W4386912953 cites W4380871686 @default.
- W4386912953 cites W4385064443 @default.
- W4386912953 doi "https://doi.org/10.3390/cancers15184663" @default.
- W4386912953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37760631" @default.
- W4386912953 hasPublicationYear "2023" @default.
- W4386912953 type Work @default.
- W4386912953 citedByCount "0" @default.
- W4386912953 crossrefType "journal-article" @default.
- W4386912953 hasAuthorship W4386912953A5001886761 @default.
- W4386912953 hasAuthorship W4386912953A5005217399 @default.
- W4386912953 hasAuthorship W4386912953A5006291712 @default.
- W4386912953 hasAuthorship W4386912953A5011980528 @default.
- W4386912953 hasAuthorship W4386912953A5014023648 @default.
- W4386912953 hasAuthorship W4386912953A5018069766 @default.
- W4386912953 hasAuthorship W4386912953A5018385660 @default.
- W4386912953 hasAuthorship W4386912953A5022124273 @default.
- W4386912953 hasAuthorship W4386912953A5026018607 @default.
- W4386912953 hasAuthorship W4386912953A5035994144 @default.
- W4386912953 hasAuthorship W4386912953A5036440273 @default.
- W4386912953 hasAuthorship W4386912953A5036720036 @default.
- W4386912953 hasAuthorship W4386912953A5038973475 @default.
- W4386912953 hasAuthorship W4386912953A5040715104 @default.
- W4386912953 hasAuthorship W4386912953A5060557396 @default.
- W4386912953 hasAuthorship W4386912953A5061814504 @default.
- W4386912953 hasAuthorship W4386912953A5064697305 @default.
- W4386912953 hasAuthorship W4386912953A5072589626 @default.
- W4386912953 hasBestOaLocation W43869129531 @default.
- W4386912953 hasConcept C104317684 @default.
- W4386912953 hasConcept C10515644 @default.
- W4386912953 hasConcept C121608353 @default.
- W4386912953 hasConcept C126322002 @default.
- W4386912953 hasConcept C143998085 @default.
- W4386912953 hasConcept C150194340 @default.
- W4386912953 hasConcept C18431079 @default.
- W4386912953 hasConcept C2781182431 @default.
- W4386912953 hasConcept C29537977 @default.
- W4386912953 hasConcept C502942594 @default.
- W4386912953 hasConcept C54355233 @default.
- W4386912953 hasConcept C71924100 @default.