Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386913478> ?p ?o ?g. }
- W4386913478 endingPage "109103" @default.
- W4386913478 startingPage "109103" @default.
- W4386913478 abstract "GSDMs could punch holes in cell membrane and participate in the immune response to bacterial infections. In current study, the molecular and structural characteristics of CcGSDMEa-like were analyzed, and the role of CcGSDMEa-like in the inflammatory response against Aeromonas hydrophila was studied. The results showed that the CcGSDMEa-like shared the conserved structural characteristics with GSDMEs of other teleosts. The CcGSDMEa-like mRNA and protein expression levels were significantly affected by A. hydrophila challenge. When the CcGSDMEa-like was overexpressed, the expression of CcIL-1β were significantly increased in fish and EPC cells, and bacterial contents were significantly decreased in fish tissues. While, when the CcGSDMEa-like was knocked down, the expression and secretion of CcIL-1β were significantly decreased in vivo and in vitro, and the bacterial contents were increased in vivo after A. hydrophila infection 12 h and 24 h. In brief, CcGSDMEa-like could regulate the content of bacteria in fish through mediating the expression and secretion of CcIL-1β. Bactericidal assay and cytotoxicity assay showed that CcGSDMEa-like had no bactericidal activity to Escherichia coli, and did not disrupt cytomembrane integrity of HEK293T cells. This study suggested that CcGSDMEa-like could play roles in the antibacterial and inflammatory processes in fish." @default.
- W4386913478 created "2023-09-22" @default.
- W4386913478 creator A5004318775 @default.
- W4386913478 creator A5005761705 @default.
- W4386913478 creator A5019159592 @default.
- W4386913478 creator A5022476363 @default.
- W4386913478 creator A5027475930 @default.
- W4386913478 creator A5049349334 @default.
- W4386913478 creator A5050163710 @default.
- W4386913478 creator A5057256487 @default.
- W4386913478 creator A5073501391 @default.
- W4386913478 creator A5091786050 @default.
- W4386913478 date "2023-11-01" @default.
- W4386913478 modified "2023-09-27" @default.
- W4386913478 title "Functional roles of CcGSDMEa-like in common carp (Cyprinus carpio) after Aeromonas hydrophila infection" @default.
- W4386913478 cites W1832266951 @default.
- W4386913478 cites W1980579273 @default.
- W4386913478 cites W1993193055 @default.
- W4386913478 cites W2048136172 @default.
- W4386913478 cites W2087638216 @default.
- W4386913478 cites W2101667253 @default.
- W4386913478 cites W2118033114 @default.
- W4386913478 cites W2165275387 @default.
- W4386913478 cites W2169864249 @default.
- W4386913478 cites W2418806051 @default.
- W4386913478 cites W2564122215 @default.
- W4386913478 cites W2608687752 @default.
- W4386913478 cites W2611391659 @default.
- W4386913478 cites W2627048017 @default.
- W4386913478 cites W2802012976 @default.
- W4386913478 cites W2924619340 @default.
- W4386913478 cites W2966052038 @default.
- W4386913478 cites W2973872894 @default.
- W4386913478 cites W2981416696 @default.
- W4386913478 cites W2983652778 @default.
- W4386913478 cites W2987088228 @default.
- W4386913478 cites W3008671055 @default.
- W4386913478 cites W3022432325 @default.
- W4386913478 cites W3023632256 @default.
- W4386913478 cites W3043910918 @default.
- W4386913478 cites W3045735444 @default.
- W4386913478 cites W3048781482 @default.
- W4386913478 cites W3107661367 @default.
- W4386913478 cites W3146986594 @default.
- W4386913478 cites W3163009041 @default.
- W4386913478 cites W3165749734 @default.
- W4386913478 cites W3180792069 @default.
- W4386913478 cites W3180977635 @default.
- W4386913478 cites W3190495276 @default.
- W4386913478 cites W3192952564 @default.
- W4386913478 cites W3199367313 @default.
- W4386913478 cites W3199855488 @default.
- W4386913478 cites W3204209426 @default.
- W4386913478 cites W3208212759 @default.
- W4386913478 cites W3215743505 @default.
- W4386913478 cites W3217135137 @default.
- W4386913478 cites W4200265819 @default.
- W4386913478 cites W4200330529 @default.
- W4386913478 cites W4220996810 @default.
- W4386913478 cites W4249254036 @default.
- W4386913478 cites W4281399696 @default.
- W4386913478 cites W4313595771 @default.
- W4386913478 cites W4383483123 @default.
- W4386913478 doi "https://doi.org/10.1016/j.fsi.2023.109103" @default.
- W4386913478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37741476" @default.
- W4386913478 hasPublicationYear "2023" @default.
- W4386913478 type Work @default.
- W4386913478 citedByCount "0" @default.
- W4386913478 crossrefType "journal-article" @default.
- W4386913478 hasAuthorship W4386913478A5004318775 @default.
- W4386913478 hasAuthorship W4386913478A5005761705 @default.
- W4386913478 hasAuthorship W4386913478A5019159592 @default.
- W4386913478 hasAuthorship W4386913478A5022476363 @default.
- W4386913478 hasAuthorship W4386913478A5027475930 @default.
- W4386913478 hasAuthorship W4386913478A5049349334 @default.
- W4386913478 hasAuthorship W4386913478A5050163710 @default.
- W4386913478 hasAuthorship W4386913478A5057256487 @default.
- W4386913478 hasAuthorship W4386913478A5073501391 @default.
- W4386913478 hasAuthorship W4386913478A5091786050 @default.
- W4386913478 hasConcept C104317684 @default.
- W4386913478 hasConcept C203014093 @default.
- W4386913478 hasConcept C207001950 @default.
- W4386913478 hasConcept C2776963538 @default.
- W4386913478 hasConcept C2778891732 @default.
- W4386913478 hasConcept C2779441561 @default.
- W4386913478 hasConcept C2780326611 @default.
- W4386913478 hasConcept C2909208804 @default.
- W4386913478 hasConcept C49039625 @default.
- W4386913478 hasConcept C505870484 @default.
- W4386913478 hasConcept C523546767 @default.
- W4386913478 hasConcept C54355233 @default.
- W4386913478 hasConcept C547475151 @default.
- W4386913478 hasConcept C55493867 @default.
- W4386913478 hasConcept C86803240 @default.
- W4386913478 hasConcept C8891405 @default.
- W4386913478 hasConcept C89423630 @default.
- W4386913478 hasConceptScore W4386913478C104317684 @default.
- W4386913478 hasConceptScore W4386913478C203014093 @default.