Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386914897> ?p ?o ?g. }
- W4386914897 abstract "Summary Dynamin 1 (Dyn1) has two major splice variants, xA and xB, with unique C-terminal extensions of 20 and 7 amino acids, respectively. Of these, only Dyn1xA is enriched at endocytic zones and accelerates vesicle fission during ultrafast endocytosis. Here, we report that the long tail variant, Dyn1xA, achieves this localization by preferentially binding to Endophilin A through a newly defined Class II binding site overlapping with its extension, at a site spanning the splice boundary. Endophilin binds this site at higher affinity than the previously reported site, and this affinity is determined by amino acids outside the binding sites acting as long distance elements within the xA tail. Their interaction is regulated by the phosphorylation state of two serine residues specific to the xA variant. Dyn1xA and Endophilin colocalize in patches near the active zone of synapses. Mutations selectively disrupting Endophilin binding to the long extension cause Dyn1xA mislocalization along axons. In these mutants, endocytic pits are stalled on the plasma membrane during ultrafast endocytosis. These data suggest that the specificity for ultrafast endocytosis is defined by the phospho-regulated interaction of Endophilin A through a newly identified site of Dyn1xA’s long tail." @default.
- W4386914897 created "2023-09-22" @default.
- W4386914897 creator A5005523254 @default.
- W4386914897 creator A5009607029 @default.
- W4386914897 creator A5010272295 @default.
- W4386914897 creator A5023814339 @default.
- W4386914897 creator A5030384422 @default.
- W4386914897 creator A5033787418 @default.
- W4386914897 creator A5043861768 @default.
- W4386914897 creator A5055173877 @default.
- W4386914897 creator A5074575943 @default.
- W4386914897 creator A5081825319 @default.
- W4386914897 creator A5081919864 @default.
- W4386914897 date "2023-09-21" @default.
- W4386914897 modified "2023-10-14" @default.
- W4386914897 title "Dynamin 1xA interacts with Endophilin A1 via its spliced long C-terminus for ultrafast endocytosis" @default.
- W4386914897 cites W1002996425 @default.
- W4386914897 cites W1507889266 @default.
- W4386914897 cites W1533663659 @default.
- W4386914897 cites W1964538907 @default.
- W4386914897 cites W1967680221 @default.
- W4386914897 cites W1971113472 @default.
- W4386914897 cites W1975081377 @default.
- W4386914897 cites W1975213336 @default.
- W4386914897 cites W1981431290 @default.
- W4386914897 cites W1984678540 @default.
- W4386914897 cites W1993505652 @default.
- W4386914897 cites W1999922223 @default.
- W4386914897 cites W2004344365 @default.
- W4386914897 cites W2005458602 @default.
- W4386914897 cites W2006955383 @default.
- W4386914897 cites W2008643711 @default.
- W4386914897 cites W2013690197 @default.
- W4386914897 cites W2015353371 @default.
- W4386914897 cites W2016166286 @default.
- W4386914897 cites W2018289835 @default.
- W4386914897 cites W2020167482 @default.
- W4386914897 cites W2024272753 @default.
- W4386914897 cites W2029980283 @default.
- W4386914897 cites W2037425715 @default.
- W4386914897 cites W2038622174 @default.
- W4386914897 cites W2040010587 @default.
- W4386914897 cites W2043242731 @default.
- W4386914897 cites W2050304765 @default.
- W4386914897 cites W2054070258 @default.
- W4386914897 cites W2061636592 @default.
- W4386914897 cites W2068177704 @default.
- W4386914897 cites W2079900215 @default.
- W4386914897 cites W2081406232 @default.
- W4386914897 cites W2082661443 @default.
- W4386914897 cites W2084285799 @default.
- W4386914897 cites W2089157578 @default.
- W4386914897 cites W2093450191 @default.
- W4386914897 cites W2093809840 @default.
- W4386914897 cites W2098732177 @default.
- W4386914897 cites W2100545357 @default.
- W4386914897 cites W2101108802 @default.
- W4386914897 cites W2101317482 @default.
- W4386914897 cites W2107305007 @default.
- W4386914897 cites W2109939279 @default.
- W4386914897 cites W2122132740 @default.
- W4386914897 cites W2124335390 @default.
- W4386914897 cites W2131411591 @default.
- W4386914897 cites W2135719485 @default.
- W4386914897 cites W2151655973 @default.
- W4386914897 cites W2154354539 @default.
- W4386914897 cites W2277097906 @default.
- W4386914897 cites W2796067132 @default.
- W4386914897 cites W2804806451 @default.
- W4386914897 cites W2809799315 @default.
- W4386914897 cites W2947951717 @default.
- W4386914897 cites W2971848333 @default.
- W4386914897 cites W2980293589 @default.
- W4386914897 cites W3037733345 @default.
- W4386914897 cites W3100679542 @default.
- W4386914897 cites W3105390201 @default.
- W4386914897 cites W3112802118 @default.
- W4386914897 cites W3132603526 @default.
- W4386914897 cites W3208691473 @default.
- W4386914897 cites W4284973934 @default.
- W4386914897 doi "https://doi.org/10.1101/2023.09.21.558797" @default.
- W4386914897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37790502" @default.
- W4386914897 hasPublicationYear "2023" @default.
- W4386914897 type Work @default.
- W4386914897 citedByCount "0" @default.
- W4386914897 crossrefType "posted-content" @default.
- W4386914897 hasAuthorship W4386914897A5005523254 @default.
- W4386914897 hasAuthorship W4386914897A5009607029 @default.
- W4386914897 hasAuthorship W4386914897A5010272295 @default.
- W4386914897 hasAuthorship W4386914897A5023814339 @default.
- W4386914897 hasAuthorship W4386914897A5030384422 @default.
- W4386914897 hasAuthorship W4386914897A5033787418 @default.
- W4386914897 hasAuthorship W4386914897A5043861768 @default.
- W4386914897 hasAuthorship W4386914897A5055173877 @default.
- W4386914897 hasAuthorship W4386914897A5074575943 @default.
- W4386914897 hasAuthorship W4386914897A5081825319 @default.
- W4386914897 hasAuthorship W4386914897A5081919864 @default.
- W4386914897 hasBestOaLocation W43869148971 @default.
- W4386914897 hasConcept C11960822 @default.
- W4386914897 hasConcept C156407911 @default.