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- W4386914906 abstract "Adoptive cell therapies continually evolve through science-based innovation. Specialized innovations for TCR-T therapies are described here that are embedded in an End-to-End Platform for TCR-T Therapy Development which aims to provide solutions for key unmet patient needs by addressing challenges of TCR-T therapy, including selection of target antigens and suitable T cell receptors, generation of TCR-T therapies that provide long term, durable efficacy and safety and development of efficient and scalable production of patient-specific (personalized) TCR-T therapy for solid tumors. Multiple, combinable, innovative technologies are used in a systematic and sequential manner in the development of TCR-T therapies. One group of technologies encompasses product enhancements that enable TCR-T therapies to be safer, more specific and more effective. The second group of technologies addresses development optimization that supports discovery and development processes for TCR-T therapies to be performed more quickly, with higher quality and greater efficiency. Each module incorporates innovations layered onto basic technologies common to the field of immunology. An active approach of evolution by innovation supports the overall goal to develop best-in-class TCR-T therapies for treatment of patients with solid cancer." @default.
- W4386914906 created "2023-09-22" @default.
- W4386914906 creator A5009178208 @default.
- W4386914906 date "2023-09-21" @default.
- W4386914906 modified "2023-10-11" @default.
- W4386914906 title "Evolution by innovation as a driving force to improve TCR-T therapies" @default.
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