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- W4386916054 abstract "Osteoporosis is a major worldwide health problem affecting bone heath. One of the most recent new therapeutic strategies that has been introduced is romosozumab. It is a humanized antibody directed against sclerostin. This is an antagonist of the Wnt signaling pathway, which is known to affect the activity of osteoblasts directly and osteoclast function indirectly. The crucial role of this molecule has been further sustained by clinical results associated with different bone diseases, including osteoporosis. Initially, results on animal models encouraged the introduction of romosozumab for osteoporosis treatment, since then different clinical trials have been organized including ARCH, FRAME, STRUCTURE, an extended trial and BRIDGE. Very interesting results have emerged thus favoring the approval of its use for osteoporosis management by the FDA and EMA, with the only recommendation being to pay particular attention to patients who have previously had a myocardial infarct." @default.
- W4386916054 created "2023-09-22" @default.
- W4386916054 creator A5009981948 @default.
- W4386916054 date "2023-01-01" @default.
- W4386916054 modified "2023-10-16" @default.
- W4386916054 title "Romosozumab: Clinical Applications, Outcomes, and Perspectives in Osteoporosis Treatment" @default.
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- W4386916054 doi "https://doi.org/10.1007/978-981-99-5826-9_3" @default.
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