Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386916296> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4386916296 abstract "<div>Abstract<p>Malignant melanoma is the most aggressive form of skin cancer; therefore, it is crucial to disclose its underlying molecular mechanisms. MicroRNAs (miRNAs) are small endogenous noncoding RNAs able to posttranscriptionally downregulate the expression of direct target genes. Using a melanoma progression model, miR-146a was identified as a key double-acting player in melanoma malignancy. In fact, miR-146a is able to enhance tumor growth, while it suppresses dissemination. It was determined that miR-146a coordinated melanoma cell growth by its direct targets lunatic fringe (LFNG) and NUMB, which operate on the NOTCH/PTEN/Akt pathway; while inhibition of metastasis formation was linked to decreased expression of ITGAV and ROCK1. Relevantly, miR-146a expression correlated with melanoma recurrence and was enriched in both patient-derived melanoma and cutaneous metastasis specimens, while its direct targets were depleted. However, miR-146a levels drop in circulating tumor cells (CTCs), suggesting the necessity for miR-146a expression to fluctuate during tumor progression in order to favor tumor growth and allow dissemination. This study reconciles the contradictory biologic functions of miR-146a in melanoma progression and unravels distinct molecular mechanisms that need to be considered for therapeutic interventions.</p><p><b>Implications:</b> miR-146a controls melanoma progression in a dual way, promoting growth and inhibiting dissemination; however, it is poorly expressed in CTCs, resulting in overall tumor spreading and distant-site colonization. <i>Mol Cancer Res; 14(6); 548–62. ©2016 AACR</i>.</p></div>" @default.
- W4386916296 created "2023-09-22" @default.
- W4386916296 creator A5009071960 @default.
- W4386916296 creator A5012376450 @default.
- W4386916296 creator A5016071296 @default.
- W4386916296 creator A5017987266 @default.
- W4386916296 creator A5019424664 @default.
- W4386916296 creator A5026491126 @default.
- W4386916296 creator A5032027734 @default.
- W4386916296 creator A5032327963 @default.
- W4386916296 creator A5049648750 @default.
- W4386916296 creator A5063120064 @default.
- W4386916296 creator A5065065492 @default.
- W4386916296 creator A5066790760 @default.
- W4386916296 date "2023-09-21" @default.
- W4386916296 modified "2023-10-16" @default.
- W4386916296 title "Data from miR-146a Exerts Differential Effects on Melanoma Growth and Metastatization" @default.
- W4386916296 doi "https://doi.org/10.1158/1541-7786.c.6846237" @default.
- W4386916296 hasPublicationYear "2023" @default.
- W4386916296 type Work @default.
- W4386916296 citedByCount "0" @default.
- W4386916296 crossrefType "posted-content" @default.
- W4386916296 hasAuthorship W4386916296A5009071960 @default.
- W4386916296 hasAuthorship W4386916296A5012376450 @default.
- W4386916296 hasAuthorship W4386916296A5016071296 @default.
- W4386916296 hasAuthorship W4386916296A5017987266 @default.
- W4386916296 hasAuthorship W4386916296A5019424664 @default.
- W4386916296 hasAuthorship W4386916296A5026491126 @default.
- W4386916296 hasAuthorship W4386916296A5032027734 @default.
- W4386916296 hasAuthorship W4386916296A5032327963 @default.
- W4386916296 hasAuthorship W4386916296A5049648750 @default.
- W4386916296 hasAuthorship W4386916296A5063120064 @default.
- W4386916296 hasAuthorship W4386916296A5065065492 @default.
- W4386916296 hasAuthorship W4386916296A5066790760 @default.
- W4386916296 hasConcept C104317684 @default.
- W4386916296 hasConcept C121608353 @default.
- W4386916296 hasConcept C126322002 @default.
- W4386916296 hasConcept C127561419 @default.
- W4386916296 hasConcept C145059251 @default.
- W4386916296 hasConcept C2777609662 @default.
- W4386916296 hasConcept C2777658100 @default.
- W4386916296 hasConcept C2779013556 @default.
- W4386916296 hasConcept C2779256057 @default.
- W4386916296 hasConcept C502942594 @default.
- W4386916296 hasConcept C55493867 @default.
- W4386916296 hasConcept C62478195 @default.
- W4386916296 hasConcept C71924100 @default.
- W4386916296 hasConcept C86554907 @default.
- W4386916296 hasConcept C86803240 @default.
- W4386916296 hasConcept C95444343 @default.
- W4386916296 hasConceptScore W4386916296C104317684 @default.
- W4386916296 hasConceptScore W4386916296C121608353 @default.
- W4386916296 hasConceptScore W4386916296C126322002 @default.
- W4386916296 hasConceptScore W4386916296C127561419 @default.
- W4386916296 hasConceptScore W4386916296C145059251 @default.
- W4386916296 hasConceptScore W4386916296C2777609662 @default.
- W4386916296 hasConceptScore W4386916296C2777658100 @default.
- W4386916296 hasConceptScore W4386916296C2779013556 @default.
- W4386916296 hasConceptScore W4386916296C2779256057 @default.
- W4386916296 hasConceptScore W4386916296C502942594 @default.
- W4386916296 hasConceptScore W4386916296C55493867 @default.
- W4386916296 hasConceptScore W4386916296C62478195 @default.
- W4386916296 hasConceptScore W4386916296C71924100 @default.
- W4386916296 hasConceptScore W4386916296C86554907 @default.
- W4386916296 hasConceptScore W4386916296C86803240 @default.
- W4386916296 hasConceptScore W4386916296C95444343 @default.
- W4386916296 hasLocation W43869162961 @default.
- W4386916296 hasOpenAccess W4386916296 @default.
- W4386916296 hasPrimaryLocation W43869162961 @default.
- W4386916296 hasRelatedWork W1788793669 @default.
- W4386916296 hasRelatedWork W1997084308 @default.
- W4386916296 hasRelatedWork W2028752124 @default.
- W4386916296 hasRelatedWork W2268266875 @default.
- W4386916296 hasRelatedWork W2740068052 @default.
- W4386916296 hasRelatedWork W2964433561 @default.
- W4386916296 hasRelatedWork W3049714071 @default.
- W4386916296 hasRelatedWork W3185101381 @default.
- W4386916296 hasRelatedWork W3208122506 @default.
- W4386916296 hasRelatedWork W4280644146 @default.
- W4386916296 isParatext "false" @default.
- W4386916296 isRetracted "false" @default.
- W4386916296 workType "article" @default.