Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386917237> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4386917237 abstract "Abstract Background Bed bug infestations are re-emerging in the poultry industry throughout the USA. Although the impacts of bed bugs on birds’ health and welfare are poorly understood, adverse outcomes are expected, including stress, anemia, infections and lower production rates. Worker welfare is also an important consideration in commercial poultry farms. A limited number of insecticides are available for use in the complex spatial environment of commercial farms. Systemic drugs have the potential to overcome the limitations of existing pest management tactics. A recent study showed that fluralaner administered to chickens caused high levels of mortality in bed bugs. Methods To further understand the efficacy of this approach, we evaluated the pharmacokinetics of an oral solid formulation of fluralaner in 11 chickens and quantified its plasma concentration in chickens using UPLC/MS. We administered fluralaner to chickens with two doses of Bravecto ® (each 0.5 mg/kg body mass) via gavage 1 week apart and evaluated its efficacy on bed bugs that fed on medicated chickens for up to 28 days post-treatment. Results Bed bugs that fed on fluralaner-treated chickens experienced > 50% mortality within 30 min of the administration of Bravecto and 100% mortality 2 days post-treatment. Mortality slowly declined to 66.6% by day 28. Fluralaner was quantifiable in the hens’ plasma for at least 28 days post-treatment. The treatment resulted in maximal plasma concentrations ( C max ) of 106.4 ng/ml around day 9.0 ( T max ), substantially higher than the LC 90 , the concentration needed to kill 90% of the bed bugs. Conclusions Fluralaner appears to be a promising candidate for bed bug control in poultry farms, with a treatment effect lasting at least 28 days. Graphical Abstract" @default.
- W4386917237 created "2023-09-22" @default.
- W4386917237 creator A5005305491 @default.
- W4386917237 creator A5007343047 @default.
- W4386917237 creator A5009788501 @default.
- W4386917237 creator A5018820235 @default.
- W4386917237 creator A5025853631 @default.
- W4386917237 creator A5039607255 @default.
- W4386917237 creator A5048323036 @default.
- W4386917237 creator A5062700217 @default.
- W4386917237 creator A5072551275 @default.
- W4386917237 creator A5089055130 @default.
- W4386917237 date "2023-09-21" @default.
- W4386917237 modified "2023-10-14" @default.
- W4386917237 title "Pharmacokinetics of fluralaner as a systemic drug to control infestations of the common bed bug, Cimex lectularius, in poultry facilities" @default.
- W4386917237 cites W2017603864 @default.
- W4386917237 cites W2045621855 @default.
- W4386917237 cites W2127375442 @default.
- W4386917237 cites W2176910918 @default.
- W4386917237 cites W2325942606 @default.
- W4386917237 cites W2532328517 @default.
- W4386917237 cites W3014366663 @default.
- W4386917237 cites W3039650372 @default.
- W4386917237 cites W4229999602 @default.
- W4386917237 cites W4240461205 @default.
- W4386917237 cites W4309518424 @default.
- W4386917237 cites W4318426649 @default.
- W4386917237 cites W4376631320 @default.
- W4386917237 cites W4379197365 @default.
- W4386917237 doi "https://doi.org/10.1186/s13071-023-05962-3" @default.
- W4386917237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37735689" @default.
- W4386917237 hasPublicationYear "2023" @default.
- W4386917237 type Work @default.
- W4386917237 citedByCount "0" @default.
- W4386917237 crossrefType "journal-article" @default.
- W4386917237 hasAuthorship W4386917237A5005305491 @default.
- W4386917237 hasAuthorship W4386917237A5007343047 @default.
- W4386917237 hasAuthorship W4386917237A5009788501 @default.
- W4386917237 hasAuthorship W4386917237A5018820235 @default.
- W4386917237 hasAuthorship W4386917237A5025853631 @default.
- W4386917237 hasAuthorship W4386917237A5039607255 @default.
- W4386917237 hasAuthorship W4386917237A5048323036 @default.
- W4386917237 hasAuthorship W4386917237A5062700217 @default.
- W4386917237 hasAuthorship W4386917237A5072551275 @default.
- W4386917237 hasAuthorship W4386917237A5089055130 @default.
- W4386917237 hasBestOaLocation W43869172371 @default.
- W4386917237 hasConcept C112705442 @default.
- W4386917237 hasConcept C18903297 @default.
- W4386917237 hasConcept C2777499811 @default.
- W4386917237 hasConcept C2778908745 @default.
- W4386917237 hasConcept C2781100537 @default.
- W4386917237 hasConcept C2908924393 @default.
- W4386917237 hasConcept C33070731 @default.
- W4386917237 hasConcept C42972112 @default.
- W4386917237 hasConcept C71924100 @default.
- W4386917237 hasConcept C86803240 @default.
- W4386917237 hasConcept C98274493 @default.
- W4386917237 hasConceptScore W4386917237C112705442 @default.
- W4386917237 hasConceptScore W4386917237C18903297 @default.
- W4386917237 hasConceptScore W4386917237C2777499811 @default.
- W4386917237 hasConceptScore W4386917237C2778908745 @default.
- W4386917237 hasConceptScore W4386917237C2781100537 @default.
- W4386917237 hasConceptScore W4386917237C2908924393 @default.
- W4386917237 hasConceptScore W4386917237C33070731 @default.
- W4386917237 hasConceptScore W4386917237C42972112 @default.
- W4386917237 hasConceptScore W4386917237C71924100 @default.
- W4386917237 hasConceptScore W4386917237C86803240 @default.
- W4386917237 hasConceptScore W4386917237C98274493 @default.
- W4386917237 hasFunder F4320306078 @default.
- W4386917237 hasFunder F4320306119 @default.
- W4386917237 hasFunder F4320332167 @default.
- W4386917237 hasIssue "1" @default.
- W4386917237 hasLocation W43869172371 @default.
- W4386917237 hasLocation W43869172372 @default.
- W4386917237 hasOpenAccess W4386917237 @default.
- W4386917237 hasPrimaryLocation W43869172371 @default.
- W4386917237 hasRelatedWork W2090953696 @default.
- W4386917237 hasRelatedWork W2340777955 @default.
- W4386917237 hasRelatedWork W2472186260 @default.
- W4386917237 hasRelatedWork W2598195567 @default.
- W4386917237 hasRelatedWork W2612236287 @default.
- W4386917237 hasRelatedWork W2915197518 @default.
- W4386917237 hasRelatedWork W2988465857 @default.
- W4386917237 hasRelatedWork W3002565196 @default.
- W4386917237 hasRelatedWork W4200276418 @default.
- W4386917237 hasRelatedWork W4309518424 @default.
- W4386917237 hasVolume "16" @default.
- W4386917237 isParatext "false" @default.
- W4386917237 isRetracted "false" @default.
- W4386917237 workType "article" @default.