FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386917585> ?p ?o ?g. }

• W4386917585 endingPage "9841" @default.
• W4386917585 startingPage "9822" @default.
• W4386917585 abstract "Glioblastoma (GBM) is a highly malignant brain cancer with a poor prognosis despite standard treatments. This investigation aimed to explore the feasibility of PTPN6 to combat GBM with immunotherapy. Our study employed a comprehensive analysis of publicly available datasets and functional experiments to assess PTPN6 gene expression, prognostic value, and related immune characteristics in glioma. We evaluated the influence of PTPN6 expression on CD8+ T cell exhaustion, immune suppression, and tumor growth in human GBM samples and mouse models. Our findings demonstrated that PTPN6 overexpression played an oncogenic role in GBM and was associated with advanced tumor grades and unfavorable clinical outcomes. In human GBM samples, PTPN6 upregulation showed a strong association with immunosuppressive formation and CD8+ T cell dysfunction, whereas, in mice, it hindered CD8+ T cell infiltration. Moreover, PTPN6 facilitated cell cycle progression, inhibited apoptosis, and promoted glioma cell proliferation, tumor growth, and colony formation in mice. The outcomes of our study indicate that PTPN6 is a promising immunotherapeutic target for the treatment of GBM. Inhibition of PTPN6 could enhance CD8+ T cell infiltration and improve antitumor immune response, thus leading to better clinical outcomes for GBM patients." @default.
• W4386917585 created "2023-09-22" @default.
• W4386917585 creator A5005468953 @default.
• W4386917585 creator A5007705431 @default.
• W4386917585 creator A5007727020 @default.
• W4386917585 creator A5010479652 @default.
• W4386917585 creator A5018239354 @default.
• W4386917585 creator A5027475930 @default.
• W4386917585 creator A5051357934 @default.
• W4386917585 creator A5070851410 @default.
• W4386917585 creator A5072851784 @default.
• W4386917585 creator A5076555816 @default.
• W4386917585 creator A5079266488 @default.
• W4386917585 creator A5083228477 @default.
• W4386917585 date "2023-09-21" @default.
• W4386917585 modified "2023-10-12" @default.
• W4386917585 title "Single-cell and bulk sequencing analyses reveal the immune suppressive role of PTPN6 in glioblastoma" @default.
• W4386917585 cites W1881534971 @default.
• W4386917585 cites W1907954732 @default.
• W4386917585 cites W1966327575 @default.
• W4386917585 cites W1982626083 @default.
• W4386917585 cites W2010457001 @default.
• W4386917585 cites W2068413770 @default.
• W4386917585 cites W2108068107 @default.
• W4386917585 cites W2123106337 @default.
• W4386917585 cites W2130410032 @default.
• W4386917585 cites W2148977460 @default.
• W4386917585 cites W2157852151 @default.
• W4386917585 cites W2230320310 @default.
• W4386917585 cites W2301304484 @default.
• W4386917585 cites W2554863679 @default.
• W4386917585 cites W2747036018 @default.
• W4386917585 cites W2794804602 @default.
• W4386917585 cites W2796207838 @default.
• W4386917585 cites W2886498337 @default.
• W4386917585 cites W2897044695 @default.
• W4386917585 cites W2916087536 @default.
• W4386917585 cites W2921460161 @default.
• W4386917585 cites W2961217357 @default.
• W4386917585 cites W3025197026 @default.
• W4386917585 cites W3088005314 @default.
• W4386917585 cites W3089940214 @default.
• W4386917585 cites W3107628845 @default.
• W4386917585 cites W3112055421 @default.
• W4386917585 cites W3135035839 @default.
• W4386917585 cites W3136975836 @default.
• W4386917585 cites W3142377309 @default.
• W4386917585 cites W3155198217 @default.
• W4386917585 cites W3157362546 @default.
• W4386917585 cites W3161379239 @default.
• W4386917585 cites W3161898928 @default.
• W4386917585 cites W3162226089 @default.
• W4386917585 cites W3163372125 @default.
• W4386917585 cites W4210607937 @default.
• W4386917585 cites W4211220688 @default.
• W4386917585 cites W4306930892 @default.
• W4386917585 doi "https://doi.org/10.18632/aging.205052" @default.
• W4386917585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37737713" @default.
• W4386917585 hasPublicationYear "2023" @default.
• W4386917585 type Work @default.
• W4386917585 citedByCount "0" @default.
• W4386917585 crossrefType "journal-article" @default.
• W4386917585 hasAuthorship W4386917585A5005468953 @default.
• W4386917585 hasAuthorship W4386917585A5007705431 @default.
• W4386917585 hasAuthorship W4386917585A5007727020 @default.
• W4386917585 hasAuthorship W4386917585A5010479652 @default.
• W4386917585 hasAuthorship W4386917585A5018239354 @default.
• W4386917585 hasAuthorship W4386917585A5027475930 @default.
• W4386917585 hasAuthorship W4386917585A5051357934 @default.
• W4386917585 hasAuthorship W4386917585A5070851410 @default.
• W4386917585 hasAuthorship W4386917585A5072851784 @default.
• W4386917585 hasAuthorship W4386917585A5076555816 @default.
• W4386917585 hasAuthorship W4386917585A5079266488 @default.
• W4386917585 hasAuthorship W4386917585A5083228477 @default.
• W4386917585 hasBestOaLocation W43869175851 @default.
• W4386917585 hasConcept C104317684 @default.
• W4386917585 hasConcept C127561419 @default.
• W4386917585 hasConcept C1491633281 @default.
• W4386917585 hasConcept C167672396 @default.
• W4386917585 hasConcept C203014093 @default.
• W4386917585 hasConcept C2777701055 @default.
• W4386917585 hasConcept C2778227246 @default.
• W4386917585 hasConcept C502942594 @default.
• W4386917585 hasConcept C54355233 @default.
• W4386917585 hasConcept C71924100 @default.
• W4386917585 hasConcept C86803240 @default.
• W4386917585 hasConcept C8891405 @default.
• W4386917585 hasConceptScore W4386917585C104317684 @default.
• W4386917585 hasConceptScore W4386917585C127561419 @default.
• W4386917585 hasConceptScore W4386917585C1491633281 @default.
• W4386917585 hasConceptScore W4386917585C167672396 @default.
• W4386917585 hasConceptScore W4386917585C203014093 @default.
• W4386917585 hasConceptScore W4386917585C2777701055 @default.
• W4386917585 hasConceptScore W4386917585C2778227246 @default.
• W4386917585 hasConceptScore W4386917585C502942594 @default.
• W4386917585 hasConceptScore W4386917585C54355233 @default.
• W4386917585 hasConceptScore W4386917585C71924100 @default.
• W4386917585 hasConceptScore W4386917585C86803240 @default.

• next