FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386919092> ?p ?o ?g. }

• W4386919092 abstract "Lipid metabolism plays an important role in the growth and development of tumors. However, the role of lipid metabolism in gallbladder cancer (GBC) has not been clearly clarified. Here, we demonstrated that fatty acid synthase (FASN), a key enzyme in de novo fatty acid biosynthesis, had upregulated expression in GBC samples both at protein and mRNA levels. Analysis of clinical data indicated the association between elevated FASN expression and poorer histology grades. Furthermore, FASN activity impairment through FASN knockdown or treatment with orlistat resulted in the inhibition of cell proliferation and migration, as well as increased sensitivity to gemcitabine. Both FASN knockdown and orlistat treatment induced cell apoptosis. Mechanistically, impairment of FASN activity suppressed the activation of the PI3K/AKT signaling pathway, which led to increased cell apoptosis and sensitivity to gemcitabine. These findings were also validated through nude mouse xenograft models, thus highlighting the potential of targeting FASN as a clinical treatment strategy. Collectively, the present study underscores the crucial role of FASN in the progression of gallbladder cancer via the PI3K/AKT pathway." @default.
• W4386919092 created "2023-09-22" @default.
• W4386919092 creator A5008584660 @default.
• W4386919092 creator A5012955949 @default.
• W4386919092 creator A5028462911 @default.
• W4386919092 creator A5031586200 @default.
• W4386919092 creator A5036755111 @default.
• W4386919092 creator A5040623969 @default.
• W4386919092 creator A5063779532 @default.
• W4386919092 date "2023-01-01" @default.
• W4386919092 modified "2023-09-30" @default.
• W4386919092 title "FASN promotes gallbladder cancer progression and reduces cancer cell sensitivity to gemcitabine through PI3K/AKT signaling" @default.
• W4386919092 cites W1501481238 @default.
• W4386919092 cites W1979294135 @default.
• W4386919092 cites W2021846401 @default.
• W4386919092 cites W2023604857 @default.
• W4386919092 cites W2062785709 @default.
• W4386919092 cites W2095707070 @default.
• W4386919092 cites W2122953618 @default.
• W4386919092 cites W2152675473 @default.
• W4386919092 cites W2153178365 @default.
• W4386919092 cites W2534024300 @default.
• W4386919092 cites W2544695096 @default.
• W4386919092 cites W2588603672 @default.
• W4386919092 cites W2608028058 @default.
• W4386919092 cites W2626868669 @default.
• W4386919092 cites W2726091305 @default.
• W4386919092 cites W2747955726 @default.
• W4386919092 cites W2771273683 @default.
• W4386919092 cites W2792311906 @default.
• W4386919092 cites W2801699880 @default.
• W4386919092 cites W2805393256 @default.
• W4386919092 cites W2904953303 @default.
• W4386919092 cites W2940716150 @default.
• W4386919092 cites W2954493501 @default.
• W4386919092 cites W2962919683 @default.
• W4386919092 cites W2979160948 @default.
• W4386919092 cites W2991159308 @default.
• W4386919092 cites W2994268592 @default.
• W4386919092 cites W3022546238 @default.
• W4386919092 cites W3081426492 @default.
• W4386919092 cites W3114796419 @default.
• W4386919092 cites W3128646645 @default.
• W4386919092 cites W3131861897 @default.
• W4386919092 cites W3180597472 @default.
• W4386919092 cites W4220678390 @default.
• W4386919092 cites W4281739318 @default.
• W4386919092 cites W4311456225 @default.
• W4386919092 cites W4316039477 @default.
• W4386919092 doi "https://doi.org/10.5582/ddt.2023.01036" @default.
• W4386919092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37743521" @default.
• W4386919092 hasPublicationYear "2023" @default.
• W4386919092 type Work @default.
• W4386919092 citedByCount "0" @default.
• W4386919092 crossrefType "journal-article" @default.
• W4386919092 hasAuthorship W4386919092A5008584660 @default.
• W4386919092 hasAuthorship W4386919092A5012955949 @default.
• W4386919092 hasAuthorship W4386919092A5028462911 @default.
• W4386919092 hasAuthorship W4386919092A5031586200 @default.
• W4386919092 hasAuthorship W4386919092A5036755111 @default.
• W4386919092 hasAuthorship W4386919092A5040623969 @default.
• W4386919092 hasAuthorship W4386919092A5063779532 @default.
• W4386919092 hasBestOaLocation W43869190921 @default.
• W4386919092 hasConcept C104317684 @default.
• W4386919092 hasConcept C121608353 @default.
• W4386919092 hasConcept C126322002 @default.
• W4386919092 hasConcept C127561419 @default.
• W4386919092 hasConcept C173396325 @default.
• W4386919092 hasConcept C185592680 @default.
• W4386919092 hasConcept C190283241 @default.
• W4386919092 hasConcept C2776534502 @default.
• W4386919092 hasConcept C2780258809 @default.
• W4386919092 hasConcept C2780780548 @default.
• W4386919092 hasConcept C4733338 @default.
• W4386919092 hasConcept C48289651 @default.
• W4386919092 hasConcept C502942594 @default.
• W4386919092 hasConcept C511355011 @default.
• W4386919092 hasConcept C544821477 @default.
• W4386919092 hasConcept C55493867 @default.
• W4386919092 hasConcept C62112901 @default.
• W4386919092 hasConcept C71924100 @default.
• W4386919092 hasConcept C75217442 @default.
• W4386919092 hasConcept C86554907 @default.
• W4386919092 hasConceptScore W4386919092C104317684 @default.
• W4386919092 hasConceptScore W4386919092C121608353 @default.
• W4386919092 hasConceptScore W4386919092C126322002 @default.
• W4386919092 hasConceptScore W4386919092C127561419 @default.
• W4386919092 hasConceptScore W4386919092C173396325 @default.
• W4386919092 hasConceptScore W4386919092C185592680 @default.
• W4386919092 hasConceptScore W4386919092C190283241 @default.
• W4386919092 hasConceptScore W4386919092C2776534502 @default.
• W4386919092 hasConceptScore W4386919092C2780258809 @default.
• W4386919092 hasConceptScore W4386919092C2780780548 @default.
• W4386919092 hasConceptScore W4386919092C4733338 @default.
• W4386919092 hasConceptScore W4386919092C48289651 @default.
• W4386919092 hasConceptScore W4386919092C502942594 @default.
• W4386919092 hasConceptScore W4386919092C511355011 @default.
• W4386919092 hasConceptScore W4386919092C544821477 @default.
• W4386919092 hasConceptScore W4386919092C55493867 @default.
• W4386919092 hasConceptScore W4386919092C62112901 @default.

• next