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- W4386923679 abstract "ABSTRACTAim In the present study the effect of donepezil hydrochloride was studied on the transgenic Drosophila expressing human Aβ-42 in the neurons.Methods Donepezil hydrochloride at final concentration of 0.1, 1 and 10 mM was mixed in the diet and the flies expressing human Aβ- 42 under UAS control (AD flies) were allowed to feed on it for 30 days.Results The AD flies exposed to various doses of Donepezil hydrochloride showed a dose dependent significant delay in the loss of climbing ability, increase in activity, reduction in the oxidative stress and apoptotic markers. A significant improvement was also observed in cognitive parameters. A dose dependent significant reduction in the activity of acetylcholinesterase was also observed. The docking studies suggest the positive interaction between donepezil, Aβ-42 and acetylcholinesterase. The results obtained from immunohistochemistry also showed a dose dependent significant reduction in the Aβ-42 aggregates.Conclusion The results suggest that donepezil hydrochloride is potent enough to reduce the AD symptoms being mimicked in transgenic flies.Keywords: Donepezil hydrochlorideAlzheimer DiseaseDrosophilaOxidative stressMolecular dockingDisclaimerAs a service to authors and researchers we are providing this version of an accepted manuscript (AM). Copyediting, typesetting, and review of the resulting proofs will be undertaken on this manuscript before final publication of the Version of Record (VoR). During production and pre-press, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal relate to these versions also. FundingThe author(s) reported there is no funding associated with the work featured in this article." @default.
- W4386923679 created "2023-09-22" @default.
- W4386923679 creator A5031246188 @default.
- W4386923679 creator A5036958467 @default.
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- W4386923679 creator A5045163988 @default.
- W4386923679 creator A5049568385 @default.
- W4386923679 creator A5082970468 @default.
- W4386923679 date "2023-09-21" @default.
- W4386923679 modified "2023-09-28" @default.
- W4386923679 title "Effect of donepezil hydrochloride on the transgenic <i>Drosophila</i> expressing human Aβ-42" @default.
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