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- W4386926126 abstract "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes several proteins that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling by disrupting nucleocytoplasmic trafficking through interactions with the nuclear pore complex components Nup98-Rae1. However, the roles and contributions of ORF6 during physiological infection remain unexplored. We assessed the role of ORF6 during infection using recombinant viruses carrying a deletion or loss-of-function (LoF) mutation in ORF6. ORF6 plays key roles in interferon antagonism and viral pathogenesis by interfering with nuclear import and specifically the translocation of IRF and STAT transcription factors. Additionally, ORF6 inhibits cellular mRNA export, resulting in the remodeling of the host cell proteome, and regulates viral protein expression. Interestingly, the ORF6:D61L mutation that emerged in the Omicron BA.2 and BA.4 variants exhibits reduced interactions with Nup98-Rae1 and consequently impairs immune evasion. Our findings highlight the role of ORF6 in antagonizing innate immunity and emphasize the importance of studying the immune evasion strategies of SARS-CoV-2." @default.
- W4386926126 created "2023-09-22" @default.
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- W4386926126 date "2023-10-01" @default.
- W4386926126 modified "2023-10-18" @default.
- W4386926126 title "Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis" @default.
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- W4386926126 cites W3088256443 @default.
- W4386926126 cites W3088885706 @default.
- W4386926126 cites W3091952647 @default.
- W4386926126 cites W3092586527 @default.
- W4386926126 cites W3093900830 @default.
- W4386926126 cites W3094558943 @default.
- W4386926126 cites W3105815895 @default.
- W4386926126 cites W3125093522 @default.
- W4386926126 cites W3134208712 @default.
- W4386926126 cites W3136850423 @default.
- W4386926126 cites W3139390776 @default.
- W4386926126 cites W3153812246 @default.
- W4386926126 cites W3154763189 @default.
- W4386926126 cites W3163640205 @default.
- W4386926126 cites W3172681111 @default.
- W4386926126 cites W3172924690 @default.
- W4386926126 cites W3176967764 @default.
- W4386926126 cites W3186354235 @default.
- W4386926126 cites W3208691473 @default.
- W4386926126 cites W3214990850 @default.
- W4386926126 cites W4200216147 @default.
- W4386926126 cites W4205998015 @default.
- W4386926126 cites W4206177062 @default.
- W4386926126 cites W4224240133 @default.