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• W4386929151 endingPage "2583" @default.
• W4386929151 startingPage "2583" @default.
• W4386929151 abstract "In diabetes, possibly the most significant site of microvascular damage is the kidney. Due to diabetes and/or other co-morbidities, such as hypertension and age-related nephron loss, a significant number of people with diabetes suffer from kidney diseases. Improved diabetic care can reduce the prevalence of diabetic nephropathy (DN); however, innovative treatment approaches are still required. MicroRNA-21 (miR-21) is one of the most studied multipotent microRNAs (miRNAs), and it has been linked to renal fibrosis and exhibits significantly altered expression in DN. Targeting miR-21 offers an advantage in DN. Currently, miR-21 is being pharmacologically silenced through various methods, all of which are in early development. In this review, we summarize the role of miR-21 in the molecular pathogenesis of DN and several therapeutic strategies to use miR-21 as a therapeutic target in DN. The existing experimental interventions offer a way to rectify the lower miRNA levels as well as to reduce the higher levels. Synthetic miRNAs also referred to as miR-mimics, can compensate for abnormally low miRNA levels. Furthermore, strategies like oligonucleotides can be used to alter the miRNA levels. It is reasonable to target miR-21 for improved results because it directly contributes to the pathological processes of kidney diseases, including DN." @default.
• W4386929151 created "2023-09-22" @default.
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• W4386929151 date "2023-09-20" @default.
• W4386929151 modified "2023-10-09" @default.
• W4386929151 title "MicroRNA-21 Silencing in Diabetic Nephropathy: Insights on Therapeutic Strategies" @default.
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• W4386929151 doi "https://doi.org/10.3390/biomedicines11092583" @default.
• W4386929151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37761024" @default.
• W4386929151 hasPublicationYear "2023" @default.
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