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- W4386929238 endingPage "6094" @default.
- W4386929238 startingPage "6094" @default.
- W4386929238 abstract "Subfertility is a global health issue, and as many as 30% of cases are attributed to unexplained reasons. A hypercaloric, high-fat diet stimulates the expansion of pro-inflammatory gut microbiota with a consequent rise in circulating lipopolysaccharides. Adverse gut microbiota remodeling can exacerbate insulin resistance, while sex and thyroid hormones may influence the variability in gut microbiota. This cross-sectional study included 150 participants and was designed to determine a biochemical, nutritional-related pattern that may distinguish subfertile from fertile individuals and couples. A panel of 28 biomarkers was assessed. Four biochemical phenotypes of unexplained subfertility were found, including two metabolic and two immune, when assessed using binary logistic regression models. Two phenotypes were distinguished in women: cardio-metabolic with atherogenic dyslipidemia (LowHDL-cholesterol: OR = 10.9; p < 0.05) and autoimmune thyroid disorder (Highanti-thyroid-peroxidase: OR = 5.5; p < 0.05) and two in men: hepato-metabolic with elevated liver injury enzymes (HighHOMA-IR: OR = 6.1; p < 0.05) and immune type-2 response (HighIgE: OR = 6.4; p < 0.05). The chances of a couple's subfertility rose with the number of laboratory components of metabolic syndrome in the couple (OR = 1.7; p < 0.05) and if at least one partner had an elevated total IgE level (>100 kU/L) (OR = 6.5; p < 0.05). This study found that unexplained subfertility may be accompanied by mutually overlapping immune and metabolic dysregulations in individuals and couples. We propose one-time laboratory diagnostics taking into account the lipid profile, insulin resistance, anti-thyroid-peroxidase, and total IgE in both males and females with unexplained subfertility. This may allow for a one-time assessment of targeted medical and nutritional interventions and help optimize patients' health. The gut-organ axes related to subfertility are discussed in the context of the obtained results." @default.
- W4386929238 created "2023-09-22" @default.
- W4386929238 creator A5028270871 @default.
- W4386929238 creator A5044463413 @default.
- W4386929238 creator A5045448355 @default.
- W4386929238 creator A5071565595 @default.
- W4386929238 date "2023-09-21" @default.
- W4386929238 modified "2023-10-17" @default.
- W4386929238 title "Subfertility as Overlapping of Nutritional, Endocrine, Immune, and Cardiometabolic Dysregulations—A Study Focused on Biochemical Endophenotypes of Subfertile Couples" @default.
- W4386929238 cites W120487505 @default.
- W4386929238 cites W1534488294 @default.
- W4386929238 cites W1597960788 @default.
- W4386929238 cites W1968156993 @default.
- W4386929238 cites W1992026402 @default.
- W4386929238 cites W2012644803 @default.
- W4386929238 cites W2013257990 @default.
- W4386929238 cites W2015946488 @default.
- W4386929238 cites W2039786614 @default.
- W4386929238 cites W2055712591 @default.
- W4386929238 cites W2056399290 @default.
- W4386929238 cites W2082068762 @default.
- W4386929238 cites W2089188696 @default.
- W4386929238 cites W2100381325 @default.
- W4386929238 cites W2107034706 @default.
- W4386929238 cites W2116639256 @default.
- W4386929238 cites W2120862552 @default.
- W4386929238 cites W2129749274 @default.
- W4386929238 cites W2130263296 @default.
- W4386929238 cites W2130886341 @default.
- W4386929238 cites W2131920157 @default.
- W4386929238 cites W2136837706 @default.
- W4386929238 cites W2149044709 @default.
- W4386929238 cites W2155195505 @default.
- W4386929238 cites W2158269238 @default.
- W4386929238 cites W2160234571 @default.
- W4386929238 cites W2164271065 @default.
- W4386929238 cites W2265429569 @default.
- W4386929238 cites W2420805559 @default.
- W4386929238 cites W2563118732 @default.
- W4386929238 cites W2598045563 @default.
- W4386929238 cites W2607031541 @default.
- W4386929238 cites W2610973115 @default.
- W4386929238 cites W2748516572 @default.
- W4386929238 cites W2752320193 @default.
- W4386929238 cites W2765724961 @default.
- W4386929238 cites W2783154851 @default.
- W4386929238 cites W2787004630 @default.
- W4386929238 cites W2790887288 @default.
- W4386929238 cites W2887468934 @default.
- W4386929238 cites W2903161537 @default.
- W4386929238 cites W2914760691 @default.
- W4386929238 cites W2924699635 @default.
- W4386929238 cites W2953804067 @default.
- W4386929238 cites W2987426172 @default.
- W4386929238 cites W3010218109 @default.
- W4386929238 cites W3016102868 @default.
- W4386929238 cites W3051382309 @default.
- W4386929238 cites W3080146064 @default.
- W4386929238 cites W3090587408 @default.
- W4386929238 cites W3110318350 @default.
- W4386929238 cites W3127932726 @default.
- W4386929238 cites W3132171162 @default.
- W4386929238 cites W3149277213 @default.
- W4386929238 cites W3163334896 @default.
- W4386929238 cites W3165508451 @default.
- W4386929238 cites W3183857127 @default.
- W4386929238 cites W3195700033 @default.
- W4386929238 cites W3198536732 @default.
- W4386929238 cites W3200910429 @default.
- W4386929238 cites W3212197474 @default.
- W4386929238 cites W3213336521 @default.
- W4386929238 cites W4200389410 @default.
- W4386929238 cites W4210349778 @default.
- W4386929238 cites W4211151293 @default.
- W4386929238 cites W4225416359 @default.
- W4386929238 cites W4249402732 @default.
- W4386929238 cites W4253046392 @default.
- W4386929238 cites W4280566938 @default.
- W4386929238 cites W4280589708 @default.
- W4386929238 cites W4280623240 @default.
- W4386929238 cites W4283712385 @default.
- W4386929238 cites W4285808873 @default.
- W4386929238 cites W4292416428 @default.
- W4386929238 cites W4293564685 @default.
- W4386929238 cites W4294584412 @default.
- W4386929238 cites W4295693818 @default.
- W4386929238 cites W4296849216 @default.
- W4386929238 cites W4298006005 @default.
- W4386929238 cites W4304003399 @default.
- W4386929238 cites W4307122582 @default.
- W4386929238 cites W4308198114 @default.
- W4386929238 cites W4308365150 @default.
- W4386929238 cites W4310741976 @default.
- W4386929238 cites W4311668965 @default.
- W4386929238 cites W4311730197 @default.
- W4386929238 cites W4313576360 @default.
- W4386929238 cites W4315498086 @default.
- W4386929238 cites W4317521201 @default.