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- W4386931166 abstract "Rationale & Objective Frailty is common in individuals with chronic kidney disease (CKD) and increases the risk of adverse outcomes in adults with kidney failure requiring dialysis. However, this relationship has not been thoroughly evaluated among those with non-dialysis dependent CKD. Study Design Prospective cohort study. Setting & Participants: 2,539 adults in the Chronic Renal Insufficiency Cohort Study. Exposure Frailty status assessed using five criteria (slow gait speed, muscle weakness, low physical activity, exhaustion, and unintentional weight loss). Outcomes Atherosclerotic events, incident heart failure, all-cause death, and cardiovascular death. Analytical Approach Cause-specific hazards models. Results At study entry, mean age was 62 years, 46% were female, mean eGFR was 45.4 mL/min/1.73m2, and median urine protein was 0.2 mg/day. Frailty status was as follows: 12% frail, 51% pre-frail, and 37% non-frail. Over a median follow-up of 11.4 years, there were 393 atherosclerotic events, 413 heart failure events, 497 deaths, and 132 cardiovascular deaths. In multivariable regression analyses, compared with non-frailty, both frailty and pre-frailty status were each associated with higher risk of an atherosclerotic event (HRs of 2.03 [95% CI, 1.41, 2.91] and 1.77 [95% CI, 1.35, 2.31], respectively) and incident heart failure (HRs 2.22 [95% CI, 1.59, 3.10] and 1.39 [95% CI, 1.07, 1.82], respectively), as well as higher risk of all-cause death (HRs of 2.52 [95% CI, 1.84, 3.45] and 1.76 [95% CI, 1.37, 2.24], respectively) and cardiovascular death (HRs of 3.01 [95% CI, 1.62, 5.62] and 1.78 [95% 1.06, 2.99], respectively). Limitations Self-report of aspects of the frailty assessment and comorbidities, which may have led to bias in some estimates. Conclusions In adults with CKD, frailty status was associated with higher risk of cardiovascular events and mortality. Future studies are needed to evaluate the impact of interventions to reduce frailty on cardiovascular outcomes in this population." @default.
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- W4386931166 date "2023-09-01" @default.
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- W4386931166 title "Frailty and Cardiovascular Outcomes in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study" @default.
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- W4386931166 doi "https://doi.org/10.1053/j.ajkd.2023.06.009" @default.
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