Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386932009> ?p ?o ?g. }
- W4386932009 endingPage "166887" @default.
- W4386932009 startingPage "166887" @default.
- W4386932009 abstract "Hypertrophic scar (HS) is a fibrotic skin condition and characterized by abnormal proliferation of myofibroblasts and accumulation of extracellular matrix. Melatonin, an endogenous hormone, can alleviate fibrosis in multiple models of diseases. This study examined the effect of melatonin on fibrosis in primary fibroblasts from human HS (HSFs) and a rabbit ear model and potential mechanisms. Melatonin treatment significantly decreased the migration and contraction capacity, collagen and α-smooth muscle actin (α-SMA) production in HSFs. RNA-sequencing and bioinformatic analyses indicated that melatonin modulated the expression of genes involved in autophagy and oxidative stress. Mechanistically, melatonin treatment attenuated the AKT/mTOR activation through affecting the binding of MT2 receptor with PI3K to enhance autophagy, decreasing fibrogenic factor production in HSFs. Moreover, melatonin treatment inhibited HS formation in rabbit ears by enhancing autophagy. The anti-fibrotic effects of melatonin were abrogated by treatment with an autophagy inhibitor (3-methyladenine, 3-MA), an Akt activator (SC79), or an MT2 selective antagonist (4-phenyl-2propionamidotetralin, 4-P-PDOT). Therefore, melatonin may be a potential drug for prevention and treatment of HS." @default.
- W4386932009 created "2023-09-22" @default.
- W4386932009 creator A5003008456 @default.
- W4386932009 creator A5006245533 @default.
- W4386932009 creator A5012285236 @default.
- W4386932009 creator A5017492903 @default.
- W4386932009 creator A5022360981 @default.
- W4386932009 creator A5028611090 @default.
- W4386932009 creator A5039896971 @default.
- W4386932009 creator A5049814996 @default.
- W4386932009 creator A5056484501 @default.
- W4386932009 creator A5065798882 @default.
- W4386932009 creator A5070926877 @default.
- W4386932009 creator A5077776876 @default.
- W4386932009 creator A5080076240 @default.
- W4386932009 creator A5090832714 @default.
- W4386932009 date "2024-01-01" @default.
- W4386932009 modified "2023-10-18" @default.
- W4386932009 title "Melatonin inhibits fibroblast cell functions and hypertrophic scar formation by enhancing autophagy through the MT2 receptor-inhibited PI3K/Akt /mTOR signaling" @default.
- W4386932009 cites W1968284335 @default.
- W4386932009 cites W1979783084 @default.
- W4386932009 cites W1985124617 @default.
- W4386932009 cites W1994823455 @default.
- W4386932009 cites W2003407164 @default.
- W4386932009 cites W2023359623 @default.
- W4386932009 cites W2048494900 @default.
- W4386932009 cites W2050834222 @default.
- W4386932009 cites W2079487466 @default.
- W4386932009 cites W2080347540 @default.
- W4386932009 cites W2081769002 @default.
- W4386932009 cites W2103560924 @default.
- W4386932009 cites W2132846300 @default.
- W4386932009 cites W2134629247 @default.
- W4386932009 cites W2156108044 @default.
- W4386932009 cites W2165989194 @default.
- W4386932009 cites W2337535943 @default.
- W4386932009 cites W2510472879 @default.
- W4386932009 cites W2526166493 @default.
- W4386932009 cites W2580057498 @default.
- W4386932009 cites W2594802210 @default.
- W4386932009 cites W2604907374 @default.
- W4386932009 cites W2607315215 @default.
- W4386932009 cites W2737775216 @default.
- W4386932009 cites W2739038996 @default.
- W4386932009 cites W2751019535 @default.
- W4386932009 cites W2783435569 @default.
- W4386932009 cites W2791951513 @default.
- W4386932009 cites W2884305610 @default.
- W4386932009 cites W2897304981 @default.
- W4386932009 cites W2901740709 @default.
- W4386932009 cites W2902139199 @default.
- W4386932009 cites W2902863353 @default.
- W4386932009 cites W2908256106 @default.
- W4386932009 cites W2909477364 @default.
- W4386932009 cites W2937578637 @default.
- W4386932009 cites W2937905141 @default.
- W4386932009 cites W2940668662 @default.
- W4386932009 cites W2941699811 @default.
- W4386932009 cites W2957001836 @default.
- W4386932009 cites W2963493768 @default.
- W4386932009 cites W3004265057 @default.
- W4386932009 cites W3006998660 @default.
- W4386932009 cites W3014344943 @default.
- W4386932009 cites W3045914946 @default.
- W4386932009 cites W3048520812 @default.
- W4386932009 cites W3058036789 @default.
- W4386932009 cites W3089882193 @default.
- W4386932009 cites W3092966039 @default.
- W4386932009 cites W4210437045 @default.
- W4386932009 cites W4288434495 @default.
- W4386932009 cites W4322718306 @default.
- W4386932009 doi "https://doi.org/10.1016/j.bbadis.2023.166887" @default.
- W4386932009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37739092" @default.
- W4386932009 hasPublicationYear "2024" @default.
- W4386932009 type Work @default.
- W4386932009 citedByCount "0" @default.
- W4386932009 crossrefType "journal-article" @default.
- W4386932009 hasAuthorship W4386932009A5003008456 @default.
- W4386932009 hasAuthorship W4386932009A5006245533 @default.
- W4386932009 hasAuthorship W4386932009A5012285236 @default.
- W4386932009 hasAuthorship W4386932009A5017492903 @default.
- W4386932009 hasAuthorship W4386932009A5022360981 @default.
- W4386932009 hasAuthorship W4386932009A5028611090 @default.
- W4386932009 hasAuthorship W4386932009A5039896971 @default.
- W4386932009 hasAuthorship W4386932009A5049814996 @default.
- W4386932009 hasAuthorship W4386932009A5056484501 @default.
- W4386932009 hasAuthorship W4386932009A5065798882 @default.
- W4386932009 hasAuthorship W4386932009A5070926877 @default.
- W4386932009 hasAuthorship W4386932009A5077776876 @default.
- W4386932009 hasAuthorship W4386932009A5080076240 @default.
- W4386932009 hasAuthorship W4386932009A5090832714 @default.
- W4386932009 hasConcept C126322002 @default.
- W4386932009 hasConcept C134018914 @default.
- W4386932009 hasConcept C185592680 @default.
- W4386932009 hasConcept C190283241 @default.
- W4386932009 hasConcept C203522944 @default.
- W4386932009 hasConcept C2778182776 @default.
- W4386932009 hasConcept C2780381497 @default.