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- W4386934851 abstract "Abstract Vertebrate color vision is predominantly mediated by the presence of multiple cone photoreceptor subtypes that are each maximally sensitive to different wavelengths of light. Thyroid hormone (TH) has been shown to be essential in the spatiotemporal patterning of cone subtypes in many species, including cone subtypes that express opsins that are encoded by tandemly replicated genes. TH has been shown to differentially regulate the tandemly replicated lws opsin genes in zebrafish, and exogenous treatments alter the expression levels of these genes in larvae and juveniles. In this study, we sought to determine whether gene expression in cone photoreceptors remains plastic to TH treatment in adults. We used a transgenic lws reporter line, multiplexed fluorescence hybridization chain reaction in situ hybridization, and qPCR to examine the extent to which cone gene expression can be altered by TH in adults. Our studies revealed that opsin gene expression, and the expression of other photoreceptor genes, remains plastic to TH treatment in adult zebrafish. In addition to retinal plasticity, exogenous TH treatment alters skin pigmentation patterns in adult zebrafish after 5 days. Taken together, our results show a remarkable level of TH-sensitive plasticity in the adult zebrafish." @default.
- W4386934851 created "2023-09-22" @default.
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- W4386934851 date "2023-09-21" @default.
- W4386934851 modified "2023-10-16" @default.
- W4386934851 title "Plasticity of cone photoreceptors in adult zebrafish revealed by thyroid hormone exposure" @default.
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- W4386934851 doi "https://doi.org/10.1038/s41598-023-42686-x" @default.
- W4386934851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37735192" @default.
- W4386934851 hasPublicationYear "2023" @default.
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