Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386936304> ?p ?o ?g. }
- W4386936304 endingPage "3456.e12" @default.
- W4386936304 startingPage "3438" @default.
- W4386936304 abstract "Transcription factors (TFs) activate enhancers to drive cell-specific gene programs in response to signals, but our understanding of enhancer assembly during signaling events is incomplete. Here, we show that androgen receptor (AR) forms condensates through multivalent interactions mediated by its N-terminal intrinsically disordered region (IDR) to orchestrate enhancer assembly in response to androgen signaling. AR IDR can be substituted by IDRs from selective proteins for AR condensation capacity and its function on enhancers. Expansion of the poly(Q) track within AR IDR results in a higher AR condensation propensity as measured by multiple methods, including live-cell single-molecule microscopy. Either weakening or strengthening AR condensation propensity impairs its heterotypic multivalent interactions with other enhancer components and diminishes its transcriptional activity. Our work reveals the requirement of an optimal level of AR condensation in mediating enhancer assembly and suggests that alteration of the fine-tuned multivalent IDR-IDR interactions might underlie AR-related human pathologies." @default.
- W4386936304 created "2023-09-22" @default.
- W4386936304 creator A5008880875 @default.
- W4386936304 creator A5012926126 @default.
- W4386936304 creator A5015769149 @default.
- W4386936304 creator A5022526821 @default.
- W4386936304 creator A5042563826 @default.
- W4386936304 creator A5047253579 @default.
- W4386936304 creator A5049119185 @default.
- W4386936304 creator A5054533847 @default.
- W4386936304 creator A5057125184 @default.
- W4386936304 creator A5057675869 @default.
- W4386936304 creator A5058180819 @default.
- W4386936304 creator A5065361552 @default.
- W4386936304 creator A5067345132 @default.
- W4386936304 creator A5077920629 @default.
- W4386936304 creator A5080536275 @default.
- W4386936304 creator A5081160974 @default.
- W4386936304 creator A5090696528 @default.
- W4386936304 date "2023-10-01" @default.
- W4386936304 modified "2023-10-13" @default.
- W4386936304 title "Hormone-induced enhancer assembly requires an optimal level of hormone receptor multivalent interactions" @default.
- W4386936304 cites W1531821806 @default.
- W4386936304 cites W1968786809 @default.
- W4386936304 cites W1974900814 @default.
- W4386936304 cites W1975839434 @default.
- W4386936304 cites W1988467765 @default.
- W4386936304 cites W1991740019 @default.
- W4386936304 cites W1995311028 @default.
- W4386936304 cites W2010519082 @default.
- W4386936304 cites W2021341670 @default.
- W4386936304 cites W2026842001 @default.
- W4386936304 cites W2027347575 @default.
- W4386936304 cites W2036321220 @default.
- W4386936304 cites W2036897871 @default.
- W4386936304 cites W2049345986 @default.
- W4386936304 cites W2073615418 @default.
- W4386936304 cites W2079196978 @default.
- W4386936304 cites W2080752012 @default.
- W4386936304 cites W2091875431 @default.
- W4386936304 cites W2093140735 @default.
- W4386936304 cites W2105707485 @default.
- W4386936304 cites W2122631256 @default.
- W4386936304 cites W2124985265 @default.
- W4386936304 cites W2132665968 @default.
- W4386936304 cites W2136364567 @default.
- W4386936304 cites W2146470265 @default.
- W4386936304 cites W2146865209 @default.
- W4386936304 cites W2149541702 @default.
- W4386936304 cites W2151922331 @default.
- W4386936304 cites W2152144700 @default.
- W4386936304 cites W2161797274 @default.
- W4386936304 cites W2170776626 @default.
- W4386936304 cites W2170830174 @default.
- W4386936304 cites W2171808845 @default.
- W4386936304 cites W2412450093 @default.
- W4386936304 cites W2463195069 @default.
- W4386936304 cites W2507000097 @default.
- W4386936304 cites W2509111410 @default.
- W4386936304 cites W2524794095 @default.
- W4386936304 cites W2534922319 @default.
- W4386936304 cites W2538965655 @default.
- W4386936304 cites W2566521622 @default.
- W4386936304 cites W2567008309 @default.
- W4386936304 cites W2590568317 @default.
- W4386936304 cites W2603000633 @default.
- W4386936304 cites W2722642526 @default.
- W4386936304 cites W2755486970 @default.
- W4386936304 cites W2756240008 @default.
- W4386936304 cites W2774429523 @default.
- W4386936304 cites W2790755828 @default.
- W4386936304 cites W2801412154 @default.
- W4386936304 cites W2804270751 @default.
- W4386936304 cites W2808847099 @default.
- W4386936304 cites W2809057270 @default.
- W4386936304 cites W2809265915 @default.
- W4386936304 cites W2810866092 @default.
- W4386936304 cites W2887741043 @default.
- W4386936304 cites W2901209536 @default.
- W4386936304 cites W2914907359 @default.
- W4386936304 cites W2920174847 @default.
- W4386936304 cites W2921273649 @default.
- W4386936304 cites W2949573765 @default.
- W4386936304 cites W2958811479 @default.
- W4386936304 cites W2968888229 @default.
- W4386936304 cites W2979601486 @default.
- W4386936304 cites W2989044169 @default.
- W4386936304 cites W2995571829 @default.
- W4386936304 cites W3003547858 @default.
- W4386936304 cites W3023736115 @default.
- W4386936304 cites W3025520651 @default.
- W4386936304 cites W3035370963 @default.
- W4386936304 cites W3042507822 @default.
- W4386936304 cites W3085471727 @default.
- W4386936304 cites W3120321944 @default.
- W4386936304 cites W3145969289 @default.
- W4386936304 cites W3156113107 @default.
- W4386936304 cites W3199764951 @default.