Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386941200> ?p ?o ?g. }
- W4386941200 endingPage "110915" @default.
- W4386941200 startingPage "110915" @default.
- W4386941200 abstract "Psoriasis is a highly prevalent chronic disease associated with a substantial social and economic burden. Oxeiptosis is a programmed cell death that occurs when cells are in a state of high oxidative stress, which has a potent anti-inflammatory effect. However, there is still no research on oxeiptosis in psoriasis, and the agonists or antagonists of oxeiptosis remain an unclear field. Here, we found that oxeiptosis of keratinocytes was inhibited in psoriasis lesions. KEAP1, as the upstream molecular component of oxeiptosis, is highly expressed in psoriasis lesions. Knockdown of KEAP1 in HaCaT cells caused oxeiptosis in the condition of M5 cocktail stimulation. Next, we found that the cell-permeable derivative of itaconate, 4-octylitaconate (OI) promoted oxeiptosis of keratinocytes by inhibiting KEAP1 and then activating PGAM5 which are two upstream molecular components of oxeiptosis. At the same time, OI can reduce the expression of inflammatory cytokines induced by M5 cocktail stimulation in vitro. Similarly, we found that OI can alleviate IMQ-induced psoriatic lesions in mice and downregulate the levels of inflammatory cytokines in psoriatic lesions. In summary, our findings suggest that oxeiptosis of keratinocytes was inhibited in psoriasis and OI can significantly inhibit inflammation and alleviate psoriasis as an agonist of oxeiptosis, indicating that oxeiptosis may be involved in regulating the progression of psoriasis, which may provide new therapeutic targets for psoriasis treatment." @default.
- W4386941200 created "2023-09-22" @default.
- W4386941200 creator A5030445322 @default.
- W4386941200 creator A5044407167 @default.
- W4386941200 creator A5046587035 @default.
- W4386941200 creator A5058190288 @default.
- W4386941200 creator A5089936647 @default.
- W4386941200 date "2023-11-01" @default.
- W4386941200 modified "2023-09-27" @default.
- W4386941200 title "4-Octyl itaconate inhibits inflammation to attenuate psoriasis as an agonist of oxeiptosis" @default.
- W4386941200 cites W1525322545 @default.
- W4386941200 cites W1560379370 @default.
- W4386941200 cites W1974124666 @default.
- W4386941200 cites W1976599392 @default.
- W4386941200 cites W1988768595 @default.
- W4386941200 cites W2002617338 @default.
- W4386941200 cites W2004532975 @default.
- W4386941200 cites W2008344420 @default.
- W4386941200 cites W2008835593 @default.
- W4386941200 cites W2043768128 @default.
- W4386941200 cites W2057943214 @default.
- W4386941200 cites W2070895853 @default.
- W4386941200 cites W2072453475 @default.
- W4386941200 cites W2077121920 @default.
- W4386941200 cites W2078184099 @default.
- W4386941200 cites W2080090843 @default.
- W4386941200 cites W2096822241 @default.
- W4386941200 cites W2113074658 @default.
- W4386941200 cites W2117800935 @default.
- W4386941200 cites W2132399579 @default.
- W4386941200 cites W2167279371 @default.
- W4386941200 cites W2342271048 @default.
- W4386941200 cites W2483443548 @default.
- W4386941200 cites W2580035316 @default.
- W4386941200 cites W2621333085 @default.
- W4386941200 cites W2623626102 @default.
- W4386941200 cites W2752721387 @default.
- W4386941200 cites W2775328130 @default.
- W4386941200 cites W2791613797 @default.
- W4386941200 cites W2794844698 @default.
- W4386941200 cites W2795505616 @default.
- W4386941200 cites W2797967513 @default.
- W4386941200 cites W2799290037 @default.
- W4386941200 cites W2799871629 @default.
- W4386941200 cites W2806138737 @default.
- W4386941200 cites W2807671526 @default.
- W4386941200 cites W2885738092 @default.
- W4386941200 cites W2895796465 @default.
- W4386941200 cites W2896292359 @default.
- W4386941200 cites W2901307786 @default.
- W4386941200 cites W2967476539 @default.
- W4386941200 cites W2968243824 @default.
- W4386941200 cites W2973266161 @default.
- W4386941200 cites W2977586303 @default.
- W4386941200 cites W2988457676 @default.
- W4386941200 cites W2999403306 @default.
- W4386941200 cites W3004429595 @default.
- W4386941200 cites W3005189635 @default.
- W4386941200 cites W3015878239 @default.
- W4386941200 cites W3016506109 @default.
- W4386941200 cites W3038565051 @default.
- W4386941200 cites W3040563619 @default.
- W4386941200 cites W3081254755 @default.
- W4386941200 cites W3082676535 @default.
- W4386941200 cites W3094804619 @default.
- W4386941200 cites W3111305063 @default.
- W4386941200 cites W3114981130 @default.
- W4386941200 cites W3126563441 @default.
- W4386941200 cites W3132811301 @default.
- W4386941200 cites W3160758742 @default.
- W4386941200 cites W3161694687 @default.
- W4386941200 cites W3189547130 @default.
- W4386941200 cites W3202725207 @default.
- W4386941200 cites W3212443296 @default.
- W4386941200 cites W4200331388 @default.
- W4386941200 cites W4206739528 @default.
- W4386941200 cites W4207067385 @default.
- W4386941200 cites W4210492916 @default.
- W4386941200 cites W4210955641 @default.
- W4386941200 cites W4211077900 @default.
- W4386941200 cites W4213142049 @default.
- W4386941200 cites W4226396506 @default.
- W4386941200 cites W4281949779 @default.
- W4386941200 cites W4283742640 @default.
- W4386941200 cites W4283795391 @default.
- W4386941200 cites W4285404202 @default.
- W4386941200 cites W4288740317 @default.
- W4386941200 cites W4309047553 @default.
- W4386941200 cites W4310569542 @default.
- W4386941200 cites W4318257722 @default.
- W4386941200 cites W4376128877 @default.
- W4386941200 doi "https://doi.org/10.1016/j.intimp.2023.110915" @default.
- W4386941200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37741130" @default.
- W4386941200 hasPublicationYear "2023" @default.
- W4386941200 type Work @default.
- W4386941200 citedByCount "0" @default.
- W4386941200 crossrefType "journal-article" @default.
- W4386941200 hasAuthorship W4386941200A5030445322 @default.