Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386944346> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4386944346 abstract "The Rho family GTPases Rac and Rho play critical roles in transmitting mechanical information contained within the extracellular matrix (ECM) to the cell. Rac and Rho have well-described roles in regulating stiffness-dependent actin remodeling, proliferation and motility. However, much less is known about the relative roles of these GTPases in stiffness-dependent transcription, particularly at the genome-wide level. Here, we selectively inhibited Rac and Rho in mouse embryonic fibroblasts cultured on deformable substrata and used RNA sequencing to elucidate and compare the contribution of these GTPases to the early transcriptional response to ECM stiffness. Surprisingly, we found that the stiffness-dependent activation of Rac was dominant over Rho in the initial transcriptional response to ECM stiffness. We also identified activating transcription factor 3 (ATF3) as a major target of stiffness- and Rac-mediated signaling and show that ATF3 repression by ECM stiffness helps to explain how the stiffness-dependent activation of Rac results in the induction of cyclin D1." @default.
- W4386944346 created "2023-09-23" @default.
- W4386944346 creator A5034995854 @default.
- W4386944346 creator A5035612918 @default.
- W4386944346 creator A5065593225 @default.
- W4386944346 creator A5089942489 @default.
- W4386944346 date "2023-09-22" @default.
- W4386944346 modified "2023-10-17" @default.
- W4386944346 title "Key role for Rac in the early transcriptional response to ECM stiffness and the stiffness-dependent repression of ATF3" @default.
- W4386944346 doi "https://doi.org/10.1242/jcs.260636" @default.
- W4386944346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37737020" @default.
- W4386944346 hasPublicationYear "2023" @default.
- W4386944346 type Work @default.
- W4386944346 citedByCount "0" @default.
- W4386944346 crossrefType "journal-article" @default.
- W4386944346 hasAuthorship W4386944346A5034995854 @default.
- W4386944346 hasAuthorship W4386944346A5035612918 @default.
- W4386944346 hasAuthorship W4386944346A5065593225 @default.
- W4386944346 hasAuthorship W4386944346A5089942489 @default.
- W4386944346 hasBestOaLocation W43869443461 @default.
- W4386944346 hasConcept C104317684 @default.
- W4386944346 hasConcept C125705527 @default.
- W4386944346 hasConcept C126619667 @default.
- W4386944346 hasConcept C150194340 @default.
- W4386944346 hasConcept C159985019 @default.
- W4386944346 hasConcept C186310378 @default.
- W4386944346 hasConcept C189165786 @default.
- W4386944346 hasConcept C192562407 @default.
- W4386944346 hasConcept C207332259 @default.
- W4386944346 hasConcept C2777093181 @default.
- W4386944346 hasConcept C2779372316 @default.
- W4386944346 hasConcept C54355233 @default.
- W4386944346 hasConcept C62478195 @default.
- W4386944346 hasConcept C69053785 @default.
- W4386944346 hasConcept C86339819 @default.
- W4386944346 hasConcept C86803240 @default.
- W4386944346 hasConcept C95444343 @default.
- W4386944346 hasConceptScore W4386944346C104317684 @default.
- W4386944346 hasConceptScore W4386944346C125705527 @default.
- W4386944346 hasConceptScore W4386944346C126619667 @default.
- W4386944346 hasConceptScore W4386944346C150194340 @default.
- W4386944346 hasConceptScore W4386944346C159985019 @default.
- W4386944346 hasConceptScore W4386944346C186310378 @default.
- W4386944346 hasConceptScore W4386944346C189165786 @default.
- W4386944346 hasConceptScore W4386944346C192562407 @default.
- W4386944346 hasConceptScore W4386944346C207332259 @default.
- W4386944346 hasConceptScore W4386944346C2777093181 @default.
- W4386944346 hasConceptScore W4386944346C2779372316 @default.
- W4386944346 hasConceptScore W4386944346C54355233 @default.
- W4386944346 hasConceptScore W4386944346C62478195 @default.
- W4386944346 hasConceptScore W4386944346C69053785 @default.
- W4386944346 hasConceptScore W4386944346C86339819 @default.
- W4386944346 hasConceptScore W4386944346C86803240 @default.
- W4386944346 hasConceptScore W4386944346C95444343 @default.
- W4386944346 hasFunder F4320306230 @default.
- W4386944346 hasFunder F4320332161 @default.
- W4386944346 hasLocation W43869443461 @default.
- W4386944346 hasLocation W43869443462 @default.
- W4386944346 hasOpenAccess W4386944346 @default.
- W4386944346 hasPrimaryLocation W43869443461 @default.
- W4386944346 hasRelatedWork W2003608685 @default.
- W4386944346 hasRelatedWork W2024546609 @default.
- W4386944346 hasRelatedWork W2043234599 @default.
- W4386944346 hasRelatedWork W2052668551 @default.
- W4386944346 hasRelatedWork W2059598052 @default.
- W4386944346 hasRelatedWork W2089809507 @default.
- W4386944346 hasRelatedWork W2107411730 @default.
- W4386944346 hasRelatedWork W2154465708 @default.
- W4386944346 hasRelatedWork W2770830320 @default.
- W4386944346 hasRelatedWork W4231400324 @default.
- W4386944346 isParatext "false" @default.
- W4386944346 isRetracted "false" @default.
- W4386944346 workType "article" @default.