Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386944562> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4386944562 abstract "Patients with chronic lymphocytic leukemia (CLL) treated with ibrutinib are at risk of developing cardiovascular side effects (CVSEs). The molecular determinants of CVSEs have not been fully elucidated. We interrogated genetic polymorphisms in the Bruton Tyrosine Kinase (BTK) signaling pathway for their association with ibrutinib-related CVSEs.We conducted a retrospective/prospective observational pharmacogenetic study of 50 patients with newly diagnosed or relapsed CLL who received ibrutinib at a starting daily dose of 420 mg for at least six months. CVSEs, primarily atrial fibrillation and hypertension, occurred in ten patients (20%), of whom four discontinued therapy. DNA was isolated from buccal swabs of all 50 patients and genotyped for 40 single nucleotide polymorphisms in GATA4, SGK1, KCNQ1, KCNA4, NPPA, and SCN5A using a customized next generation sequencing panel. Univariate and multivariate logistic regression analysis were performed to determine genetic and clinical factors associated with the incidence of ibrutinib-related CVSEs.GATA4 rs804280 AA (P =.043), KCNQ1 rs163182 GG (P =.036) and KCNQ1 rs2237895 AA (P =.023) genotypes were univariately associated with ibrutinib-related CVSEs. Based on multivariate analysis, a high genetic risk score, defined as the presence of at least two of these genotypes, was associated with 11.5-fold increased odds of CVSEs (P =.019; 95% CI, 1.79-119.73).Our findings suggest possible genetic determinants of ibrutinib-related CVSEs in CLL. If replicated in a larger study, pre-treatment pharmacogenetic testing for GATA4 and KCNQ1 polymorphisms may be a useful clinical tool for personalizing treatment selection for CLL and/or instituting early risk-mitigation strategies." @default.
- W4386944562 created "2023-09-23" @default.
- W4386944562 creator A5000591015 @default.
- W4386944562 creator A5006796378 @default.
- W4386944562 creator A5016679262 @default.
- W4386944562 creator A5017645198 @default.
- W4386944562 creator A5027193786 @default.
- W4386944562 creator A5035890812 @default.
- W4386944562 creator A5038762317 @default.
- W4386944562 creator A5056838649 @default.
- W4386944562 creator A5059317772 @default.
- W4386944562 creator A5061229251 @default.
- W4386944562 creator A5069014112 @default.
- W4386944562 creator A5070252326 @default.
- W4386944562 creator A5074766331 @default.
- W4386944562 creator A5088351219 @default.
- W4386944562 date "2023-09-22" @default.
- W4386944562 modified "2023-09-28" @default.
- W4386944562 title "Genetic Predictors of Ibrutinib-Related Cardiovascular Side Effects in Patients with Chronic Lymphocytic Leukemia" @default.
- W4386944562 doi "https://doi.org/10.1158/1078-0432.ccr-23-0421" @default.
- W4386944562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37738027" @default.
- W4386944562 hasPublicationYear "2023" @default.
- W4386944562 type Work @default.
- W4386944562 citedByCount "0" @default.
- W4386944562 crossrefType "journal-article" @default.
- W4386944562 hasAuthorship W4386944562A5000591015 @default.
- W4386944562 hasAuthorship W4386944562A5006796378 @default.
- W4386944562 hasAuthorship W4386944562A5016679262 @default.
- W4386944562 hasAuthorship W4386944562A5017645198 @default.
- W4386944562 hasAuthorship W4386944562A5027193786 @default.
- W4386944562 hasAuthorship W4386944562A5035890812 @default.
- W4386944562 hasAuthorship W4386944562A5038762317 @default.
- W4386944562 hasAuthorship W4386944562A5056838649 @default.
- W4386944562 hasAuthorship W4386944562A5059317772 @default.
- W4386944562 hasAuthorship W4386944562A5061229251 @default.
- W4386944562 hasAuthorship W4386944562A5069014112 @default.
- W4386944562 hasAuthorship W4386944562A5070252326 @default.
- W4386944562 hasAuthorship W4386944562A5074766331 @default.
- W4386944562 hasAuthorship W4386944562A5088351219 @default.
- W4386944562 hasConcept C126322002 @default.
- W4386944562 hasConcept C143998085 @default.
- W4386944562 hasConcept C144301174 @default.
- W4386944562 hasConcept C156957248 @default.
- W4386944562 hasConcept C170493617 @default.
- W4386944562 hasConcept C2777938653 @default.
- W4386944562 hasConcept C2778461978 @default.
- W4386944562 hasConcept C2779878957 @default.
- W4386944562 hasConcept C38180746 @default.
- W4386944562 hasConcept C42362537 @default.
- W4386944562 hasConcept C71924100 @default.
- W4386944562 hasConcept C90059517 @default.
- W4386944562 hasConceptScore W4386944562C126322002 @default.
- W4386944562 hasConceptScore W4386944562C143998085 @default.
- W4386944562 hasConceptScore W4386944562C144301174 @default.
- W4386944562 hasConceptScore W4386944562C156957248 @default.
- W4386944562 hasConceptScore W4386944562C170493617 @default.
- W4386944562 hasConceptScore W4386944562C2777938653 @default.
- W4386944562 hasConceptScore W4386944562C2778461978 @default.
- W4386944562 hasConceptScore W4386944562C2779878957 @default.
- W4386944562 hasConceptScore W4386944562C38180746 @default.
- W4386944562 hasConceptScore W4386944562C42362537 @default.
- W4386944562 hasConceptScore W4386944562C71924100 @default.
- W4386944562 hasConceptScore W4386944562C90059517 @default.
- W4386944562 hasLocation W43869445621 @default.
- W4386944562 hasLocation W43869445622 @default.
- W4386944562 hasOpenAccess W4386944562 @default.
- W4386944562 hasPrimaryLocation W43869445621 @default.
- W4386944562 hasRelatedWork W2035536649 @default.
- W4386944562 hasRelatedWork W2071549499 @default.
- W4386944562 hasRelatedWork W2226560286 @default.
- W4386944562 hasRelatedWork W2316021978 @default.
- W4386944562 hasRelatedWork W2417539529 @default.
- W4386944562 hasRelatedWork W2529033697 @default.
- W4386944562 hasRelatedWork W4210347204 @default.
- W4386944562 hasRelatedWork W4225515604 @default.
- W4386944562 hasRelatedWork W4286270432 @default.
- W4386944562 hasRelatedWork W4377088465 @default.
- W4386944562 isParatext "false" @default.
- W4386944562 isRetracted "false" @default.
- W4386944562 workType "article" @default.