FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386944897> ?p ?o ?g. }

• W4386944897 abstract "Chronic active Epstein-Barr virus infection (CAEBV) and Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) are rare but life-threatening progressive diseases triggered by EBV infection. Glucocorticoid/immunosuppressants treatment is temporarily effective; however, most patients relapse and/or progress. Hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy; however, there are risks of transplantation-associated complications. Currently there is no standard treatment for CAEBV and EBV-HLH. Programmed death protein 1 (PD-1) inhibitors have achieved a high response in many EBV-related diseases. Sintilimab (a recombinant human IgG4 monoclonal antibody against PD-1) disrupts the interaction between PD-1 and its ligand, leading to T cell reinvigoration.A retrospective analysis was performed on three children with CAEBV or EBV-HLH in the Children's Hospital of Soochow University between 12 December 2020 and 28 November 2022. The efficacy of sintilimab was evaluated.Three patients, including two males and one female, were analyzed. Among them, two children were diagnosed with CAEBV with intermittent fever for more than four years, and one child was diagnosed with EBV-HLH. After sintilimab treatment and a mean follow-up of 17.1 months (range 10.0-23.3 months), patients 1 and 3 achieved a complete clinical response and patient 2 achieved a partial clinical response. All three children showed a > 50% decrease in EBV-DNA load in both blood and plasma. EBV-DNA copies in sorted T, B, and NK cells were also markedly decreased after sintilimab treatment.Our data supported the efficacy of PD-1 targeted therapy in certain patients with CAEBV and EBV-HLH, and suggested that sintilimab could provide a cure for these diseases, without HSCT. More prospective studies and longer follow-up are needed to confirm these conclusions." @default.
• W4386944897 created "2023-09-23" @default.
• W4386944897 creator A5015223478 @default.
• W4386944897 creator A5015903362 @default.
• W4386944897 creator A5018274654 @default.
• W4386944897 creator A5018588573 @default.
• W4386944897 creator A5045484026 @default.
• W4386944897 creator A5054219126 @default.
• W4386944897 creator A5067196925 @default.
• W4386944897 creator A5073411736 @default.
• W4386944897 creator A5079490969 @default.
• W4386944897 creator A5087319096 @default.
• W4386944897 creator A5090591934 @default.
• W4386944897 date "2023-09-22" @default.
• W4386944897 modified "2023-10-01" @default.
• W4386944897 title "Sintilimab treatment for chronic active Epstein–Barr virus infection and Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis in children" @default.
• W4386944897 cites W2104350866 @default.
• W4386944897 cites W2130473166 @default.
• W4386944897 cites W2166844298 @default.
• W4386944897 cites W2171741398 @default.
• W4386944897 cites W2264306193 @default.
• W4386944897 cites W2529923789 @default.
• W4386944897 cites W2586276931 @default.
• W4386944897 cites W2622400061 @default.
• W4386944897 cites W2739022313 @default.
• W4386944897 cites W2757190301 @default.
• W4386944897 cites W2800777307 @default.
• W4386944897 cites W2884397450 @default.
• W4386944897 cites W2890331370 @default.
• W4386944897 cites W2894427135 @default.
• W4386944897 cites W2896902798 @default.
• W4386944897 cites W2910820266 @default.
• W4386944897 cites W2922189394 @default.
• W4386944897 cites W2947424137 @default.
• W4386944897 cites W2977648831 @default.
• W4386944897 cites W3000471804 @default.
• W4386944897 cites W3011824547 @default.
• W4386944897 cites W3012091221 @default.
• W4386944897 cites W3014004967 @default.
• W4386944897 cites W3037061790 @default.
• W4386944897 cites W3081151658 @default.
• W4386944897 cites W3108515906 @default.
• W4386944897 cites W3118237671 @default.
• W4386944897 cites W3120321900 @default.
• W4386944897 cites W3152653358 @default.
• W4386944897 cites W4206578965 @default.
• W4386944897 cites W4220952662 @default.
• W4386944897 cites W4225270935 @default.
• W4386944897 cites W4226106094 @default.
• W4386944897 cites W4284963678 @default.
• W4386944897 cites W4295540029 @default.
• W4386944897 cites W4306922885 @default.
• W4386944897 cites W4313528537 @default.
• W4386944897 cites W4318263172 @default.
• W4386944897 cites W4323859239 @default.
• W4386944897 cites W4376646211 @default.
• W4386944897 cites W4376875753 @default.
• W4386944897 doi "https://doi.org/10.1186/s13023-023-02861-9" @default.
• W4386944897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37736751" @default.
• W4386944897 hasPublicationYear "2023" @default.
• W4386944897 type Work @default.
• W4386944897 citedByCount "0" @default.
• W4386944897 crossrefType "journal-article" @default.
• W4386944897 hasAuthorship W4386944897A5015223478 @default.
• W4386944897 hasAuthorship W4386944897A5015903362 @default.
• W4386944897 hasAuthorship W4386944897A5018274654 @default.
• W4386944897 hasAuthorship W4386944897A5018588573 @default.
• W4386944897 hasAuthorship W4386944897A5045484026 @default.
• W4386944897 hasAuthorship W4386944897A5054219126 @default.
• W4386944897 hasAuthorship W4386944897A5067196925 @default.
• W4386944897 hasAuthorship W4386944897A5073411736 @default.
• W4386944897 hasAuthorship W4386944897A5079490969 @default.
• W4386944897 hasAuthorship W4386944897A5087319096 @default.
• W4386944897 hasAuthorship W4386944897A5090591934 @default.
• W4386944897 hasBestOaLocation W43869448971 @default.
• W4386944897 hasConcept C126322002 @default.
• W4386944897 hasConcept C203014093 @default.
• W4386944897 hasConcept C2522874641 @default.
• W4386944897 hasConcept C2777408962 @default.
• W4386944897 hasConcept C2779079688 @default.
• W4386944897 hasConcept C2779134260 @default.
• W4386944897 hasConcept C2781375147 @default.
• W4386944897 hasConcept C2911091166 @default.
• W4386944897 hasConcept C71924100 @default.
• W4386944897 hasConceptScore W4386944897C126322002 @default.
• W4386944897 hasConceptScore W4386944897C203014093 @default.
• W4386944897 hasConceptScore W4386944897C2522874641 @default.
• W4386944897 hasConceptScore W4386944897C2777408962 @default.
• W4386944897 hasConceptScore W4386944897C2779079688 @default.
• W4386944897 hasConceptScore W4386944897C2779134260 @default.
• W4386944897 hasConceptScore W4386944897C2781375147 @default.
• W4386944897 hasConceptScore W4386944897C2911091166 @default.
• W4386944897 hasConceptScore W4386944897C71924100 @default.
• W4386944897 hasIssue "1" @default.
• W4386944897 hasLocation W43869448971 @default.
• W4386944897 hasLocation W43869448972 @default.
• W4386944897 hasOpenAccess W4386944897 @default.
• W4386944897 hasPrimaryLocation W43869448971 @default.
• W4386944897 hasRelatedWork W113694161 @default.
• W4386944897 hasRelatedWork W1899548024 @default.

• next