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- W4386945119 abstract "Abstract Telomere dysfunction is a notable event observed in many cancers contributing to their genomic instability. A major factor controlling telomere stability is the human telomerase reverse transcriptase catalytic subunit (hTERT). Telomere shortening has been observed in multiple myeloma (MM), a plasma cell malignancy with a complex and heterogeneous genetic background. In the present study, we aimed to analyse telomere length and h TERT genetic variants as potential markers of risk and survival in 251 MM patients. We found that telomere length was significantly shorter in MM patients than in healthy individuals, and patients with more advanced disease (stage III according to the International Staging System) had shorter telomeres than patients with less advanced disease. MM patients with h TERT allele rs2736100 T were characterized with significantly shorter progression-free survival (PFS). Moreover, allele rs2736100 T was also found to be less common in patients with disease progression in response to treatment. h TERT rs2853690 T was associated with higher haemoglobin blood levels and lower C-reactive protein. In conclusion, our results suggest that telomere length and h TERT genetic variability may affect MM development and can be potential prognostic markers in this disease." @default.
- W4386945119 created "2023-09-23" @default.
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- W4386945119 date "2023-09-22" @default.
- W4386945119 modified "2023-10-16" @default.
- W4386945119 title "Telomere length and hTERT genetic variants as potential prognostic markers in multiple myeloma" @default.
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- W4386945119 cites W2024809912 @default.
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- W4386945119 cites W2037236933 @default.
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- W4386945119 doi "https://doi.org/10.1038/s41598-023-43141-7" @default.
- W4386945119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37737335" @default.
- W4386945119 hasPublicationYear "2023" @default.
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