FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386945593> ?p ?o ?g. }

• W4386945593 abstract "Immune checkpoint inhibitors have revolutionized the treatment of malignancies. However, disproportionate enrollment among races and ethnicities places the generalizability of global trial results in doubt.In this systematic review, phase 3 randomized controlled trials investigating pembrolizumab in advanced cancers and providing subgroup analyses of Asian and non-Asian participants were included. The primary and secondary effect measures were the mean differences (MDs) in the natural logarithms of the hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS) between these two subgroups, respectively. We used random-effects meta-analysis to calculate the pooled ratios of HRs (i.e., exp(MD)) and implemented a meta-regression analysis to identify significant covariates.A total of 17 and 11 trials were included in the meta-analyses of OS and PFS, respectively. These trials included 2732 (25.49%) Asian and 7000 (65.32%) non-Asian participants in the OS analysis and 1438 (22.5%) Asian and 4129 (64.61%) non-Asian participants in the PFS analysis. The pooled ratio of HRs for OS was 0.87 (95% CI: 0.76-0.99; p = 0.0391), favoring Asian participants, but no significant difference was found in PFS (pooled ratio of HRs: 0.93; 95% CI: 0.82-1.07; p = 0.2391). Both linear meta-regression analyses revealed an open-label design as a crucial covariate, which indicated more benefits for non-Asian participants.Compared with non-Asian patients, Asian patients with advanced cancers may derive superior OS benefits from pembrolizumab. Although the results warrant further exploration, this meta-analysis provides insight into clinical research design." @default.
• W4386945593 created "2023-09-23" @default.
• W4386945593 creator A5007140901 @default.
• W4386945593 creator A5009424735 @default.
• W4386945593 creator A5009846821 @default.
• W4386945593 creator A5033582283 @default.
• W4386945593 creator A5048558239 @default.
• W4386945593 creator A5054458525 @default.
• W4386945593 creator A5063940560 @default.
• W4386945593 creator A5079843501 @default.
• W4386945593 creator A5082579378 @default.
• W4386945593 date "2023-09-22" @default.
• W4386945593 modified "2023-10-17" @default.
• W4386945593 title "Disparity in survival benefits of pembrolizumab between Asian and <scp>non‐Asian</scp> patients with advanced cancers: A systematic review and <scp>meta‐regression</scp> analysis" @default.
• W4386945593 cites W1964502734 @default.
• W4386945593 cites W2016901953 @default.
• W4386945593 cites W2085477178 @default.
• W4386945593 cites W2125435699 @default.
• W4386945593 cites W2129590156 @default.
• W4386945593 cites W2139168999 @default.
• W4386945593 cites W2150024391 @default.
• W4386945593 cites W2150048477 @default.
• W4386945593 cites W2152897456 @default.
• W4386945593 cites W2198093519 @default.
• W4386945593 cites W2303464565 @default.
• W4386945593 cites W2527905628 @default.
• W4386945593 cites W2588916311 @default.
• W4386945593 cites W2747107882 @default.
• W4386945593 cites W2777461561 @default.
• W4386945593 cites W2796582438 @default.
• W4386945593 cites W2804413675 @default.
• W4386945593 cites W2806614796 @default.
• W4386945593 cites W2808822836 @default.
• W4386945593 cites W2892640821 @default.
• W4386945593 cites W2903493423 @default.
• W4386945593 cites W2907028960 @default.
• W4386945593 cites W2910245285 @default.
• W4386945593 cites W2913745075 @default.
• W4386945593 cites W2925446385 @default.
• W4386945593 cites W2943108118 @default.
• W4386945593 cites W2946614049 @default.
• W4386945593 cites W2956888684 @default.
• W4386945593 cites W2962324833 @default.
• W4386945593 cites W2963476376 @default.
• W4386945593 cites W2964829965 @default.
• W4386945593 cites W2977339506 @default.
• W4386945593 cites W2979076666 @default.
• W4386945593 cites W2986633517 @default.
• W4386945593 cites W2988830956 @default.
• W4386945593 cites W2989613707 @default.
• W4386945593 cites W2990602950 @default.
• W4386945593 cites W3030178583 @default.
• W4386945593 cites W3030432790 @default.
• W4386945593 cites W3037990514 @default.
• W4386945593 cites W3082736986 @default.
• W4386945593 cites W3084362113 @default.
• W4386945593 cites W3092384992 @default.
• W4386945593 cites W3093923068 @default.
• W4386945593 cites W3107533236 @default.
• W4386945593 cites W3108133918 @default.
• W4386945593 cites W3109066472 @default.
• W4386945593 cites W3109853980 @default.
• W4386945593 cites W3110528877 @default.
• W4386945593 cites W3116378180 @default.
• W4386945593 cites W3118615836 @default.
• W4386945593 cites W3123893780 @default.
• W4386945593 cites W3131063362 @default.
• W4386945593 cites W3135755572 @default.
• W4386945593 cites W3137610925 @default.
• W4386945593 cites W3152878368 @default.
• W4386945593 cites W3164197656 @default.
• W4386945593 cites W3164672296 @default.
• W4386945593 cites W3165293110 @default.
• W4386945593 cites W3170009576 @default.
• W4386945593 cites W3195935456 @default.
• W4386945593 cites W3197648443 @default.
• W4386945593 cites W3200231835 @default.
• W4386945593 cites W3204336527 @default.
• W4386945593 cites W3204548506 @default.
• W4386945593 cites W4200006936 @default.
• W4386945593 cites W4200581891 @default.
• W4386945593 cites W4200595129 @default.
• W4386945593 cites W4205155919 @default.
• W4386945593 cites W4210685329 @default.
• W4386945593 cites W4213356935 @default.
• W4386945593 cites W4214559180 @default.
• W4386945593 cites W4223510971 @default.
• W4386945593 cites W4226407945 @default.
• W4386945593 cites W4281621907 @default.
• W4386945593 cites W4310598274 @default.
• W4386945593 doi "https://doi.org/10.1002/cam4.6563" @default.
• W4386945593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37737544" @default.
• W4386945593 hasPublicationYear "2023" @default.
• W4386945593 type Work @default.
• W4386945593 citedByCount "0" @default.
• W4386945593 crossrefType "journal-article" @default.
• W4386945593 hasAuthorship W4386945593A5007140901 @default.
• W4386945593 hasAuthorship W4386945593A5009424735 @default.
• W4386945593 hasAuthorship W4386945593A5009846821 @default.
• W4386945593 hasAuthorship W4386945593A5033582283 @default.

• next