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- W4386946557 abstract "Abstract Double hit lymphoma (DHL) and double-expressor lymphoma (DEL) are now considered as aggressive types of diffuse large B cell lymphoma. DHL is characterized by a dual rearrangement of MYC and B cell lymphoma 2 (BCL-2) and/or B cell lymphoma 6 (BCL-6) and DEL by overexpression of MYC and BCL-2. Both DHL and DEL have aggressive presentation and are more common in elderly population. We present a case of 1 ½ years old boy who presented with bilateral proptosis, and diagnosed as non-Hodgkin lymphoma with central nervous system involvement. Immunohistochemistry revealed high expression of MYC and BCL-2. Fluorescence in situ hybridization studies done to rule out DHL showed no translocation of C-MYC, Bcl-2, and Bcl-6 and hence were confirmed as double-expressor high-grade B cell lymphoma. Dual expression of C- MYC, Bcl-2, or Bcl-6 always needs further evaluation to rule out the more aggressive DHL subtypes." @default.
- W4386946557 created "2023-09-23" @default.
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- W4386946557 date "2023-09-22" @default.
- W4386946557 modified "2023-09-28" @default.
- W4386946557 title "Double-Expressor Lymphoma in a Young Child—A Case Report and Review of Literature" @default.
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- W4386946557 doi "https://doi.org/10.1055/s-0043-1772233" @default.
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