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- W4386947310 endingPage "117482" @default.
- W4386947310 startingPage "117482" @default.
- W4386947310 abstract "Neuropilin-1 (NRP-1) is a major co-receptor of vascular endothelial growth factor receptor-2 (VEGFR-2). It may also stimulate tumour growth and metastasis independently of VEGF-A165. These functions make VEGF-A165/NRP-1 complex formation and its inhibition of great interest, where NRP-1 is the target for which effective ligands are sought. Design of peptide-like inhibitors represent a strategy with great potential in the treatment of NRP-1-related disorders. Here, we present the synthesis, molecular modelling, structure-activity relationship studies as well as biological evaluation of peptides with the branched sequences H2N-X-Lys(hArg)-Dab-Oic-Arg-OH and H2N-Lys(X-hArg)-Dab-Oic-Arg-OH. Two of the designed peptides, in which Cys was inserted in X position, expressed high affinity (∼40 nM value) for NRP-1 and were resistant to enzymatic digestion in human serum. Moreover, peptide/NRP-1 complex promoted fast intracytoplasmic protein trafficking towards the plasma membrane in breast cancer cells. Our results suggest that these compounds might be good candidates for further development of VEGF-A165/NRP-1 inhibitors." @default.
- W4386947310 created "2023-09-23" @default.
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- W4386947310 date "2023-10-01" @default.
- W4386947310 modified "2023-10-15" @default.
- W4386947310 title "Structure-activity relationship studies and biological properties evaluation of peptidic NRP-1 ligands: Investigation of N-terminal cysteine importance" @default.
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- W4386947310 cites W1984901196 @default.
- W4386947310 cites W1989460836 @default.
- W4386947310 cites W1989658253 @default.
- W4386947310 cites W1990264812 @default.
- W4386947310 cites W1994573674 @default.
- W4386947310 cites W1997307365 @default.
- W4386947310 cites W2000091530 @default.
- W4386947310 cites W2003147884 @default.
- W4386947310 cites W2003240567 @default.
- W4386947310 cites W2003742281 @default.
- W4386947310 cites W2005467912 @default.
- W4386947310 cites W2010641085 @default.
- W4386947310 cites W2011841073 @default.
- W4386947310 cites W2013040233 @default.
- W4386947310 cites W2013184812 @default.
- W4386947310 cites W2014608793 @default.
- W4386947310 cites W2017205210 @default.
- W4386947310 cites W2017351811 @default.
- W4386947310 cites W2018526639 @default.
- W4386947310 cites W2028978651 @default.
- W4386947310 cites W2035736602 @default.
- W4386947310 cites W2038283518 @default.
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- W4386947310 doi "https://doi.org/10.1016/j.bmc.2023.117482" @default.
- W4386947310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37774449" @default.
- W4386947310 hasPublicationYear "2023" @default.
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