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- W4386948787 abstract "Inactivating mutations of ARID1A are detected in many endometrial epithelium-derived neoplasms, including uterine endometrioid carcinoma (EMCA). ARID1A encodes BAF250 that participates in SWI/SNF chromatin remodeling, essential for transcriptional regulation and DNA damage repair. We have created a genetically engineered murine low-grade EMCA model via tissue-specific co-deletion of ARID1A and PTEN in the murine endometrial epithelium. Single-cell analysis on mouse EMCA tissues showed a prominent population of myeloid-derived suppressor cells (MDSCs), which are pathologically activated immature neutrophils and monocytes that have potent immunosuppressive functions in solid tumors. Based on this new finding, we characterized the immune microenvironment in this murine tumor model and verified novel immunophenotypes in patients with EMCA using both in-house endometrial cancer tissue cohorts and The Cancer Genome Atlas (TCGA) dataset." @default.
- W4386948787 created "2023-09-23" @default.
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- W4386948787 date "2023-09-01" @default.
- W4386948787 modified "2023-09-29" @default.
- W4386948787 title "Characterization of myeloid-derived suppressor cells (MDSCs) in endometrial cancer (2292)" @default.
- W4386948787 doi "https://doi.org/10.1016/j.ygyno.2023.06.410" @default.
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