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- W4386951293 abstract "Sepsis is an acute systemic infectious syndrome with high fatality. Fast and accurate diagnosis, monitoring, and medication of sepsis are essential. We exploited the fluorescent metal-AIEgen frameworks (MAFs) and demonstrated the dual functions of protein detection and bacteria identification: (i) ultrasensitive point-of-care (POC) detection of sepsis biomarkers (100 times enhanced sensitivity); (ii) rapid POC identification of Gram-negative/positive bacteria (selective aggregation within 20 min). Fluorescent lateral flow immunoassays (LFAs) are convenient and inexpensive for POC tests. MAFs possess a large surface area, excellent photostability, high quantum yield (∼80%), and multiple active sites serving as protein binding domains for ultrasensitive detection of sepsis biomarkers (IL-6/PCT) on LFAs. The limit of detection (LOD) for IL-6/PCT is 0.252/0.333 pg/mL. Rapid appraisal of infectious bacteria is vital to guide the use of medicines. The dual-functional fluorescent MAFs have great potential in POC tests for the clinical diagnosis of bacterial infections." @default.
- W4386951293 created "2023-09-23" @default.
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- W4386951293 date "2023-09-22" @default.
- W4386951293 modified "2023-10-18" @default.
- W4386951293 title "Dual Functional Ultrasensitive Point-of-Care Clinical Diagnosis Using Metal–Organic Frameworks-Based Immunobeads" @default.
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- W4386951293 doi "https://doi.org/10.1021/acs.nanolett.3c02828" @default.
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