Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386954757> ?p ?o ?g. }
- W4386954757 abstract "This study aimed to explore the role and mechanism of felodipine in lung cancer therapy. Murine subcutaneous lung squamous cancer (LUSC) models constructed by KLN-205 cells were utilized to assess the effect of felodipine monotherapy and in combination with the programmed cell death protein 1 antibody (PD1ab) and cytotoxic T lymphocyte-associated antigen-4 (CTLA4ab). Immunohistochemistry analysis was subsequently applied to detect the number of CD8+ T cells and Ki67+ cells. Lastly, a series of in vitro and in vivo experiments were performed to evaluate the effects of felodipine on human LUSC cells and explore the preliminary mechanism underlying felodipine inhibition. The results revealed that felodipine monotherapy exerted a significant inhibitory effect on LUSC growth and synergistic antitumoral activity with PD1ab and CTLA4ab. Meanwhile, immunohistochemistry analysis displayed that felodipine promoted CD8+ T-cell infiltration and downregulated Ki67 expression in tumor cells. Moreover, in vitro and in vivo experiments utilizing human LUSC cells determined that felodipine impaired the proliferative and migratory abilities of cancer cells. In addition, TCGA data analysis uncovered that nuclear factor of activated T cell (NFAT1) expression was positively correlated with overall survival and disease-free survival. Finally, the cell counting kit-8 assay signaled that felodipine might suppress tumor growth by modulating NFAT1." @default.
- W4386954757 created "2023-09-23" @default.
- W4386954757 creator A5000167144 @default.
- W4386954757 creator A5018213787 @default.
- W4386954757 date "2023-01-01" @default.
- W4386954757 modified "2023-09-29" @default.
- W4386954757 title "The antihypertensive felodipine shows synergistic activity with immune checkpoint blockade and inhibits tumor growth via NFAT1 in LUSC" @default.
- W4386954757 cites W1587414944 @default.
- W4386954757 cites W1970680117 @default.
- W4386954757 cites W1971027475 @default.
- W4386954757 cites W2003433881 @default.
- W4386954757 cites W2037865099 @default.
- W4386954757 cites W2061725286 @default.
- W4386954757 cites W2072980989 @default.
- W4386954757 cites W2088292832 @default.
- W4386954757 cites W2302759685 @default.
- W4386954757 cites W2527905628 @default.
- W4386954757 cites W2589103622 @default.
- W4386954757 cites W2589817604 @default.
- W4386954757 cites W2601978056 @default.
- W4386954757 cites W2646110020 @default.
- W4386954757 cites W2750583612 @default.
- W4386954757 cites W2890158083 @default.
- W4386954757 cites W2900800104 @default.
- W4386954757 cites W2903553774 @default.
- W4386954757 cites W2928523876 @default.
- W4386954757 cites W2953136267 @default.
- W4386954757 cites W2986970931 @default.
- W4386954757 cites W2989845311 @default.
- W4386954757 cites W2994949240 @default.
- W4386954757 cites W3016623021 @default.
- W4386954757 cites W3024311959 @default.
- W4386954757 cites W3036355578 @default.
- W4386954757 cites W3037373442 @default.
- W4386954757 cites W3081130925 @default.
- W4386954757 cites W3095674084 @default.
- W4386954757 cites W3128351812 @default.
- W4386954757 cites W3128646645 @default.
- W4386954757 cites W3134840300 @default.
- W4386954757 cites W3137016118 @default.
- W4386954757 cites W3157848957 @default.
- W4386954757 cites W3164791653 @default.
- W4386954757 cites W3181199234 @default.
- W4386954757 cites W3182795444 @default.
- W4386954757 cites W3195441296 @default.
- W4386954757 cites W3207023981 @default.
- W4386954757 cites W3210306676 @default.
- W4386954757 cites W4200291004 @default.
- W4386954757 cites W4205997245 @default.
- W4386954757 cites W4206557760 @default.
- W4386954757 cites W4206801412 @default.
- W4386954757 cites W4210745723 @default.
- W4386954757 cites W4226284094 @default.
- W4386954757 cites W4286742004 @default.
- W4386954757 cites W4293158366 @default.
- W4386954757 doi "https://doi.org/10.1515/med-2023-0801" @default.
- W4386954757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37750075" @default.
- W4386954757 hasPublicationYear "2023" @default.
- W4386954757 type Work @default.
- W4386954757 citedByCount "0" @default.
- W4386954757 crossrefType "journal-article" @default.
- W4386954757 hasAuthorship W4386954757A5000167144 @default.
- W4386954757 hasAuthorship W4386954757A5018213787 @default.
- W4386954757 hasBestOaLocation W43869547571 @default.
- W4386954757 hasConcept C126322002 @default.
- W4386954757 hasConcept C134018914 @default.
- W4386954757 hasConcept C150903083 @default.
- W4386954757 hasConcept C154317977 @default.
- W4386954757 hasConcept C167672396 @default.
- W4386954757 hasConcept C170493617 @default.
- W4386954757 hasConcept C202751555 @default.
- W4386954757 hasConcept C203014093 @default.
- W4386954757 hasConcept C204232928 @default.
- W4386954757 hasConcept C207001950 @default.
- W4386954757 hasConcept C2776885963 @default.
- W4386954757 hasConcept C2780648877 @default.
- W4386954757 hasConcept C502942594 @default.
- W4386954757 hasConcept C55493867 @default.
- W4386954757 hasConcept C62112901 @default.
- W4386954757 hasConcept C71924100 @default.
- W4386954757 hasConcept C84393581 @default.
- W4386954757 hasConcept C86803240 @default.
- W4386954757 hasConcept C8891405 @default.
- W4386954757 hasConcept C98274493 @default.
- W4386954757 hasConceptScore W4386954757C126322002 @default.
- W4386954757 hasConceptScore W4386954757C134018914 @default.
- W4386954757 hasConceptScore W4386954757C150903083 @default.
- W4386954757 hasConceptScore W4386954757C154317977 @default.
- W4386954757 hasConceptScore W4386954757C167672396 @default.
- W4386954757 hasConceptScore W4386954757C170493617 @default.
- W4386954757 hasConceptScore W4386954757C202751555 @default.
- W4386954757 hasConceptScore W4386954757C203014093 @default.
- W4386954757 hasConceptScore W4386954757C204232928 @default.
- W4386954757 hasConceptScore W4386954757C207001950 @default.
- W4386954757 hasConceptScore W4386954757C2776885963 @default.
- W4386954757 hasConceptScore W4386954757C2780648877 @default.
- W4386954757 hasConceptScore W4386954757C502942594 @default.
- W4386954757 hasConceptScore W4386954757C55493867 @default.
- W4386954757 hasConceptScore W4386954757C62112901 @default.
- W4386954757 hasConceptScore W4386954757C71924100 @default.