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- W4386959689 abstract "Cilia biogenesis relies on intraflagellar transport (IFT), a conserved transport mechanism which functions bi-directionally to bring protein complexes to the growing ciliary tip and recycle signaling and transport proteins between the cilium and cell body. In Drosophila, anterograde IFT is critical for assembly of sensory cilia in the neurons of both chordotonal (ch) organs, which have relatively long ciliary axonemes, and external sensory (es) organs, which have short axonemal segments with microtubules in distal sensory segments forming non-axonemal bundles. We previously isolated the beethoven (btv) mutant in a mutagenesis screen for auditory mutants. Although many btv mutant flies are deaf, some retain a small residual auditory function as determined both by behavior and by auditory electrophysiology.Here we molecularly characterize the btv gene and demonstrate that it encodes the IFT-associated dynein-2 heavy chain Dync2h1. We also describe morphological changes in Johnston's organ as flies age to 30 days, and we find that morphological and electrophysiological phenotypes in this ch organ of btv mutants become more severe with age. We show that NompB protein, encoding the conserved IFT88 protein, an IFT complex B component, fails to be cleared from chordotonal cilia in btv mutants, instead accumulating in the distorted cilia. In macrochaete bristles, a class of es organ, btv mutants show a 50% reduction in mechanoreceptor potentials.Thus, the btv-encoded Dync2h1 functions as the retrograde IFT motor in the assembly of long ciliary axonemes in ch organs and is also important for normal function of the short ciliary axonemes in es organs." @default.
- W4386959689 created "2023-09-23" @default.
- W4386959689 creator A5011829911 @default.
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- W4386959689 date "2023-09-22" @default.
- W4386959689 modified "2023-10-11" @default.
- W4386959689 title "The retrograde IFT dynein is required for normal function of diverse mechanosensory cilia in Drosophila" @default.
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- W4386959689 doi "https://doi.org/10.3389/fnmol.2023.1263411" @default.
- W4386959689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37808471" @default.
- W4386959689 hasPublicationYear "2023" @default.
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