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- W4386963128 abstract "Tumor spheroids are one of the well-characterized 3D culture systems bearing close resemblance to the physiological tissue organization and complexity of avascular solid tumor stage with hypoxic core. They hold a wide-spread application in the field of pharmaceutical science and anti-cancer drug research. However, the difficulty in determining optimal technique for the generation of spheroids with uniform size and shape, evaluation of experimental outputs, or mass production often limits their usage in anti-cancer research and in high-throughput drug screening. In recent times, several studies have demonstrated various simple techniques for generating uniform-size 3D spheroids, including the hanging drop (HD), liquid overlay technique (LOT), and microfluidic approaches. Morphological alterations apart from biochemical assays, and staining techniques are suitably employed for the evaluation of experimental outcomes within 3D spheroid models. Morphological alterations in response to effective anti-cancer drug treatment in 3D tumor spheroids such as reduced spheroid size, loss of spheroid compactness and integrity or smooth surface, are highly reliable. These alterations can significantly reduce the need for biochemical assays and staining techniques, resulting in both time and cost savings. The present article specifically covers a variety of available procedures in spheroid generation. For practical applicability, we have supplemented our review study with the generation of glioblastoma U87 spheroids using HD and LOT methods. Additionally, we have also incorporated the outcome of U87 spheroid treatment with doxorubicin on spheroid morphology." @default.
- W4386963128 created "2023-09-23" @default.
- W4386963128 creator A5001219880 @default.
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- W4386963128 date "2023-09-20" @default.
- W4386963128 modified "2023-10-18" @default.
- W4386963128 title "3D tumor spheroids: morphological alterations a yardstick to anti-cancer drug response" @default.
- W4386963128 cites W1008722671 @default.
- W4386963128 cites W1489161277 @default.
- W4386963128 cites W1846199177 @default.
- W4386963128 cites W1937374016 @default.
- W4386963128 cites W1969179779 @default.
- W4386963128 cites W1982510502 @default.
- W4386963128 cites W1985471235 @default.
- W4386963128 cites W1986167683 @default.
- W4386963128 cites W1987661736 @default.
- W4386963128 cites W1989936643 @default.
- W4386963128 cites W1998679085 @default.
- W4386963128 cites W2000744297 @default.
- W4386963128 cites W2005204750 @default.
- W4386963128 cites W2015249420 @default.
- W4386963128 cites W2027024102 @default.
- W4386963128 cites W2027154963 @default.
- W4386963128 cites W2028066677 @default.
- W4386963128 cites W2033278321 @default.
- W4386963128 cites W2034330200 @default.
- W4386963128 cites W2034550273 @default.
- W4386963128 cites W2034728598 @default.
- W4386963128 cites W2039206383 @default.
- W4386963128 cites W2042856264 @default.
- W4386963128 cites W2045365006 @default.
- W4386963128 cites W2046788495 @default.
- W4386963128 cites W2047848650 @default.
- W4386963128 cites W2049682885 @default.
- W4386963128 cites W2050165619 @default.
- W4386963128 cites W2055498672 @default.
- W4386963128 cites W2055845630 @default.
- W4386963128 cites W2061789450 @default.
- W4386963128 cites W2063277203 @default.
- W4386963128 cites W2070243930 @default.
- W4386963128 cites W2072588000 @default.
- W4386963128 cites W2075889966 @default.
- W4386963128 cites W2083205840 @default.
- W4386963128 cites W2084461677 @default.
- W4386963128 cites W2086788386 @default.
- W4386963128 cites W2087657750 @default.
- W4386963128 cites W2092880308 @default.
- W4386963128 cites W2099862537 @default.
- W4386963128 cites W2102897174 @default.
- W4386963128 cites W2110285297 @default.
- W4386963128 cites W2111842868 @default.
- W4386963128 cites W2114229735 @default.
- W4386963128 cites W2117058819 @default.
- W4386963128 cites W2119698183 @default.
- W4386963128 cites W2121982033 @default.
- W4386963128 cites W2126251731 @default.
- W4386963128 cites W2130438064 @default.
- W4386963128 cites W2133031196 @default.
- W4386963128 cites W2136445803 @default.
- W4386963128 cites W2147043620 @default.
- W4386963128 cites W2147478966 @default.
- W4386963128 cites W2154555172 @default.
- W4386963128 cites W2157355425 @default.
- W4386963128 cites W2166241889 @default.
- W4386963128 cites W2172160601 @default.
- W4386963128 cites W2179285960 @default.
- W4386963128 cites W2195734016 @default.
- W4386963128 cites W2208720153 @default.
- W4386963128 cites W2236643502 @default.
- W4386963128 cites W2271913647 @default.
- W4386963128 cites W2275011229 @default.
- W4386963128 cites W2294123759 @default.
- W4386963128 cites W2314697488 @default.
- W4386963128 cites W2317055602 @default.
- W4386963128 cites W2325167642 @default.
- W4386963128 cites W2326883052 @default.
- W4386963128 cites W2329158748 @default.
- W4386963128 cites W2332155194 @default.
- W4386963128 cites W2336103880 @default.
- W4386963128 cites W2340470410 @default.
- W4386963128 cites W2399959131 @default.
- W4386963128 cites W2412416736 @default.
- W4386963128 cites W2415955117 @default.
- W4386963128 cites W2416425138 @default.
- W4386963128 cites W2418686488 @default.
- W4386963128 cites W2469549708 @default.
- W4386963128 cites W2473880663 @default.
- W4386963128 cites W2509845469 @default.
- W4386963128 cites W2529586600 @default.
- W4386963128 cites W2529646893 @default.