Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386965294> ?p ?o ?g. }
- W4386965294 endingPage "147823" @default.
- W4386965294 startingPage "147823" @default.
- W4386965294 abstract "The aim of this study was to obtain the Lactobacillus plantarum ATCC14917 with high-level resistance to penicillin and evaluate their probiotic traits using laboratory evolution assay and whole-genome sequencing. In penicillin environment, the minimum inhibitory concentration (MIC) of L. plantarum to penicillin increased from 1 μg/mL to 16 μg/mL and remained stable after the removal of antibiotic pressure, suggesting that the resistance acquisition to penicillin was an irreversible process. Subsequently, change of probiotic characteristics was further evaluated, and the results showed that the acid tolerance, bile tolerance and adhesion ability were significantly declined in the highly resistant strains. Whole-genome sequencing indicated that genes encoding hypothetical protein, LPXTG-motif cell wall anchor domain protein and acetyltransferase were detected in highly resistant L. plantarum, and these genes were still present after the following subculture in the absence of penicillin, suggesting that these three mutants might be the main reason for the development of penicillin resistance. The homology-based analysis of surrounding DNA regions of mutant genes was further performed and indicated that no resistant genes were located on mobile elements in evolved L. plantarum strains, signifying that the spread of antibiotic resistance genes in the gut would not occur for these mutant genes. This study provided a basis for the combined use of highly resistant L. plantarum and penicillin in the treatment of pathogen induced gut diseases." @default.
- W4386965294 created "2023-09-23" @default.
- W4386965294 creator A5000797636 @default.
- W4386965294 creator A5039896720 @default.
- W4386965294 creator A5067423333 @default.
- W4386965294 creator A5076944284 @default.
- W4386965294 creator A5079527716 @default.
- W4386965294 date "2024-01-01" @default.
- W4386965294 modified "2023-10-14" @default.
- W4386965294 title "Evaluation of penicillin-resistance and probiotic traits in Lactobacillus plantarum during laboratory evolution" @default.
- W4386965294 cites W1770841622 @default.
- W4386965294 cites W1979237147 @default.
- W4386965294 cites W1981467182 @default.
- W4386965294 cites W1994534225 @default.
- W4386965294 cites W1997043141 @default.
- W4386965294 cites W1998543052 @default.
- W4386965294 cites W2000450805 @default.
- W4386965294 cites W2033829415 @default.
- W4386965294 cites W2034672767 @default.
- W4386965294 cites W2034806366 @default.
- W4386965294 cites W2040086491 @default.
- W4386965294 cites W2042568509 @default.
- W4386965294 cites W2058659772 @default.
- W4386965294 cites W2110344308 @default.
- W4386965294 cites W2121086899 @default.
- W4386965294 cites W2183626701 @default.
- W4386965294 cites W2475885067 @default.
- W4386965294 cites W2511086568 @default.
- W4386965294 cites W2550095445 @default.
- W4386965294 cites W2597022140 @default.
- W4386965294 cites W2786890762 @default.
- W4386965294 cites W2901326206 @default.
- W4386965294 cites W2912695317 @default.
- W4386965294 cites W2942413767 @default.
- W4386965294 cites W2968451217 @default.
- W4386965294 cites W2988908896 @default.
- W4386965294 cites W2991093702 @default.
- W4386965294 cites W3003569286 @default.
- W4386965294 cites W3004528496 @default.
- W4386965294 cites W3009269518 @default.
- W4386965294 cites W3087318638 @default.
- W4386965294 cites W3089039942 @default.
- W4386965294 cites W3093156582 @default.
- W4386965294 cites W3120733179 @default.
- W4386965294 cites W3121975274 @default.
- W4386965294 cites W3162038454 @default.
- W4386965294 cites W3184764714 @default.
- W4386965294 cites W4200535340 @default.
- W4386965294 cites W4280528510 @default.
- W4386965294 cites W45667069 @default.
- W4386965294 doi "https://doi.org/10.1016/j.gene.2023.147823" @default.
- W4386965294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37741594" @default.
- W4386965294 hasPublicationYear "2024" @default.
- W4386965294 type Work @default.
- W4386965294 citedByCount "0" @default.
- W4386965294 crossrefType "journal-article" @default.
- W4386965294 hasAuthorship W4386965294A5000797636 @default.
- W4386965294 hasAuthorship W4386965294A5039896720 @default.
- W4386965294 hasAuthorship W4386965294A5067423333 @default.
- W4386965294 hasAuthorship W4386965294A5076944284 @default.
- W4386965294 hasAuthorship W4386965294A5079527716 @default.
- W4386965294 hasConcept C104317684 @default.
- W4386965294 hasConcept C143065580 @default.
- W4386965294 hasConcept C174802600 @default.
- W4386965294 hasConcept C2775920511 @default.
- W4386965294 hasConcept C2778985185 @default.
- W4386965294 hasConcept C2780255968 @default.
- W4386965294 hasConcept C501593827 @default.
- W4386965294 hasConcept C523546767 @default.
- W4386965294 hasConcept C54355233 @default.
- W4386965294 hasConcept C86803240 @default.
- W4386965294 hasConcept C89423630 @default.
- W4386965294 hasConcept C94665300 @default.
- W4386965294 hasConceptScore W4386965294C104317684 @default.
- W4386965294 hasConceptScore W4386965294C143065580 @default.
- W4386965294 hasConceptScore W4386965294C174802600 @default.
- W4386965294 hasConceptScore W4386965294C2775920511 @default.
- W4386965294 hasConceptScore W4386965294C2778985185 @default.
- W4386965294 hasConceptScore W4386965294C2780255968 @default.
- W4386965294 hasConceptScore W4386965294C501593827 @default.
- W4386965294 hasConceptScore W4386965294C523546767 @default.
- W4386965294 hasConceptScore W4386965294C54355233 @default.
- W4386965294 hasConceptScore W4386965294C86803240 @default.
- W4386965294 hasConceptScore W4386965294C89423630 @default.
- W4386965294 hasConceptScore W4386965294C94665300 @default.
- W4386965294 hasLocation W43869652941 @default.
- W4386965294 hasLocation W43869652942 @default.
- W4386965294 hasOpenAccess W4386965294 @default.
- W4386965294 hasPrimaryLocation W43869652941 @default.
- W4386965294 hasRelatedWork W1958176239 @default.
- W4386965294 hasRelatedWork W1967421806 @default.
- W4386965294 hasRelatedWork W2056857562 @default.
- W4386965294 hasRelatedWork W2068407850 @default.
- W4386965294 hasRelatedWork W2102755799 @default.
- W4386965294 hasRelatedWork W2401291924 @default.
- W4386965294 hasRelatedWork W2761021459 @default.
- W4386965294 hasRelatedWork W2766952284 @default.
- W4386965294 hasRelatedWork W2965369470 @default.