FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386965404> ?p ?o ?g. }

• W4386965404 abstract "Abstract The human colon hosts hundreds of commensal bacterial species, many of which ferment complex dietary carbohydrates. To transform these fibers into metabolically-accessible compounds, microbes often express series of dedicated enzymes homologous to the starch utilization system (sus) encoded in polysaccharide utilization loci (PULs). The genome of Bacteroides thetaiotaomicron (Bt), a common member of the human gut microbiota, encodes nearly 100 PULs, conferring a strong metabolic versatility. While the structures and functions of individual enzymes within the PULs have been investigated, little is known about how polysaccharide complexity impacts the function of sus-like systems. We here show that the activity of sus-like systems depends on polysaccharide size, ultimately impacting bacterial growth. We demonstrate the effect of size-dependent metabolism in the context of dextran metabolism driven by the specific utilization system PUL48. We find that as molecular weight of dextran increases, Bt growth rate decreases and lag time increases. At the enzymatic level, the dextranase BT3087 is the main glycosylhydrolase for dextran utilization and that BT3087 and BT3088 contribute to Bt dextran metabolism in a size-dependent manner. Finally, we show that the polysaccharide size-dependent metabolism of Bt impacts its metabolic output in a way that modulates the composition of a producer-consumer community it forms with Bacteroides fragilis . Altogether, our results expose an overlooked aspect of Bt metabolism which can impact the composition and diversity of microbiota." @default.
• W4386965404 created "2023-09-23" @default.
• W4386965404 creator A5008459119 @default.
• W4386965404 creator A5024025171 @default.
• W4386965404 creator A5044356395 @default.
• W4386965404 creator A5063533218 @default.
• W4386965404 creator A5085053142 @default.
• W4386965404 creator A5092923610 @default.
• W4386965404 date "2023-09-21" @default.
• W4386965404 modified "2023-09-27" @default.
• W4386965404 title "Bacteroides thetaiotaomicron metabolic activity decreases with polysaccharide molecular weight" @default.
• W4386965404 cites W1498344264 @default.
• W4386965404 cites W1716920228 @default.
• W4386965404 cites W1870327252 @default.
• W4386965404 cites W1905906149 @default.
• W4386965404 cites W1971586666 @default.
• W4386965404 cites W1977958579 @default.
• W4386965404 cites W1985609109 @default.
• W4386965404 cites W2019678196 @default.
• W4386965404 cites W2032230795 @default.
• W4386965404 cites W2039021127 @default.
• W4386965404 cites W2042045767 @default.
• W4386965404 cites W2044482540 @default.
• W4386965404 cites W2044977356 @default.
• W4386965404 cites W2060872094 @default.
• W4386965404 cites W2072742911 @default.
• W4386965404 cites W2082993947 @default.
• W4386965404 cites W2084512022 @default.
• W4386965404 cites W2085927856 @default.
• W4386965404 cites W2107809838 @default.
• W4386965404 cites W2110665441 @default.
• W4386965404 cites W2114887144 @default.
• W4386965404 cites W2136171779 @default.
• W4386965404 cites W2167692246 @default.
• W4386965404 cites W2345460740 @default.
• W4386965404 cites W2531616867 @default.
• W4386965404 cites W2597428467 @default.
• W4386965404 cites W2605479728 @default.
• W4386965404 cites W2737938730 @default.
• W4386965404 cites W2749229660 @default.
• W4386965404 cites W2774827951 @default.
• W4386965404 cites W2790489036 @default.
• W4386965404 cites W2947508095 @default.
• W4386965404 cites W2969197547 @default.
• W4386965404 cites W3034682989 @default.
• W4386965404 cites W3098371378 @default.
• W4386965404 cites W3124611869 @default.
• W4386965404 cites W3133800719 @default.
• W4386965404 cites W3177010995 @default.
• W4386965404 cites W3207093269 @default.
• W4386965404 cites W4206950245 @default.
• W4386965404 cites W4225984179 @default.
• W4386965404 cites W4294281058 @default.
• W4386965404 cites W4308844535 @default.
• W4386965404 cites W4380367744 @default.
• W4386965404 doi "https://doi.org/10.1101/2023.09.21.558885" @default.
• W4386965404 hasPublicationYear "2023" @default.
• W4386965404 type Work @default.
• W4386965404 citedByCount "0" @default.
• W4386965404 crossrefType "posted-content" @default.
• W4386965404 hasAuthorship W4386965404A5008459119 @default.
• W4386965404 hasAuthorship W4386965404A5024025171 @default.
• W4386965404 hasAuthorship W4386965404A5044356395 @default.
• W4386965404 hasAuthorship W4386965404A5063533218 @default.
• W4386965404 hasAuthorship W4386965404A5085053142 @default.
• W4386965404 hasAuthorship W4386965404A5092923610 @default.
• W4386965404 hasBestOaLocation W43869654041 @default.
• W4386965404 hasConcept C100817775 @default.
• W4386965404 hasConcept C101014631 @default.
• W4386965404 hasConcept C143121216 @default.
• W4386965404 hasConcept C151730666 @default.
• W4386965404 hasConcept C17093226 @default.
• W4386965404 hasConcept C181199279 @default.
• W4386965404 hasConcept C185592680 @default.
• W4386965404 hasConcept C2777339698 @default.
• W4386965404 hasConcept C2778168646 @default.
• W4386965404 hasConcept C2779343474 @default.
• W4386965404 hasConcept C2780246119 @default.
• W4386965404 hasConcept C2908934157 @default.
• W4386965404 hasConcept C501593827 @default.
• W4386965404 hasConcept C523546767 @default.
• W4386965404 hasConcept C54355233 @default.
• W4386965404 hasConcept C55493867 @default.
• W4386965404 hasConcept C62231903 @default.
• W4386965404 hasConcept C86803240 @default.
• W4386965404 hasConceptScore W4386965404C100817775 @default.
• W4386965404 hasConceptScore W4386965404C101014631 @default.
• W4386965404 hasConceptScore W4386965404C143121216 @default.
• W4386965404 hasConceptScore W4386965404C151730666 @default.
• W4386965404 hasConceptScore W4386965404C17093226 @default.
• W4386965404 hasConceptScore W4386965404C181199279 @default.
• W4386965404 hasConceptScore W4386965404C185592680 @default.
• W4386965404 hasConceptScore W4386965404C2777339698 @default.
• W4386965404 hasConceptScore W4386965404C2778168646 @default.
• W4386965404 hasConceptScore W4386965404C2779343474 @default.
• W4386965404 hasConceptScore W4386965404C2780246119 @default.
• W4386965404 hasConceptScore W4386965404C2908934157 @default.
• W4386965404 hasConceptScore W4386965404C501593827 @default.
• W4386965404 hasConceptScore W4386965404C523546767 @default.
• W4386965404 hasConceptScore W4386965404C54355233 @default.

• next