FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386965450> ?p ?o ?g. }

• W4386965450 abstract "Abstract Candida albicans is one of them most common causes of fungal disease in humans and is a commensal member of the human microbiome. The ability of C. albicans to cause disease is tightly correlated with its ability to undergo a morphological transition from budding yeast to a filamentous form (hyphae and pseudohyphae). This morphological transition is accompanied by the induction of a set of well characterized hyphae-associated genes and transcriptional regulators. To date, the vast majority of data regarding this process has been based on in vitro studies of filamentation using a range of inducing conditions. Recently, we developed an in vivo imaging approach that allows the direct characterization of morphological transition during mammalian infection. Here, we couple this imaging assay with in vivo expression profiling to characterize the time course of in vivo filamentation and the accompanying changes in gene expression. We also compare in vivo observations to in vitro filamentation using a medium (RPMI 1640 tissue culture medium with 10% bovine calf serum) widely used to mimic host conditions. From these data, we make the following conclusions regarding in vivo and in vitro filamentation. First, the transcriptional programs regulating filamentation are rapidly induced in vitro and in vivo. Second, the tempo of filamentation in vivo is prolonged relative to in vitro filamentation and the period of high expression of genes associated with that process is also prolonged. Third, hyphae are adapting to changing infection environments after filamentation has reached steady-state. Importance Candida albicans filamentation is correlated with virulence and is an intensively studied aspect of C. albicans biology. The vast majority of studies on C. albicans filamentation are based on in vitro induction of hyphae and pseudohyphae. Here we used an in vivo filamentation assay and in vivo expression profiling to compare the tempo of morphogenesis and gene expression between in vitro and in vivo filamentation. Although the hyphal gene expression profile is induced rapidly in both conditions, it remains stably expressed over the 24hr time course in vivo while the expression of other environmentally responsive genes is dynamic. As such, it is important to regard the filamentation process as a separate growth phase of C. albicans that is as adaptable to changing growth conditions as the more familiar yeast phase." @default.
• W4386965450 created "2023-09-23" @default.
• W4386965450 creator A5073942574 @default.
• W4386965450 creator A5076058258 @default.
• W4386965450 date "2023-09-21" @default.
• W4386965450 modified "2023-10-05" @default.
• W4386965450 title "Comparative dynamics of gene expression during in vitro and in vivo Candida albicans filamentation." @default.
• W4386965450 cites W1982151856 @default.
• W4386965450 cites W1997437177 @default.
• W4386965450 cites W2004992298 @default.
• W4386965450 cites W2041611856 @default.
• W4386965450 cites W2048093614 @default.
• W4386965450 cites W2053937029 @default.
• W4386965450 cites W2079559855 @default.
• W4386965450 cites W2098979038 @default.
• W4386965450 cites W2100005543 @default.
• W4386965450 cites W2135707527 @default.
• W4386965450 cites W2152727338 @default.
• W4386965450 cites W2157151790 @default.
• W4386965450 cites W2219549308 @default.
• W4386965450 cites W2757510089 @default.
• W4386965450 cites W2899480717 @default.
• W4386965450 cites W2921726164 @default.
• W4386965450 cites W3119274485 @default.
• W4386965450 cites W3157237762 @default.
• W4386965450 cites W3164944640 @default.
• W4386965450 cites W3207424466 @default.
• W4386965450 cites W4200437538 @default.
• W4386965450 cites W4211178015 @default.
• W4386965450 cites W4225000371 @default.
• W4386965450 cites W4307965771 @default.
• W4386965450 cites W4322494661 @default.
• W4386965450 cites W4324018374 @default.
• W4386965450 cites W4385304583 @default.
• W4386965450 doi "https://doi.org/10.1101/2023.09.21.558874" @default.
• W4386965450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37790536" @default.
• W4386965450 hasPublicationYear "2023" @default.
• W4386965450 type Work @default.
• W4386965450 citedByCount "0" @default.
• W4386965450 crossrefType "posted-content" @default.
• W4386965450 hasAuthorship W4386965450A5073942574 @default.
• W4386965450 hasAuthorship W4386965450A5076058258 @default.
• W4386965450 hasBestOaLocation W43869654501 @default.
• W4386965450 hasConcept C104317684 @default.
• W4386965450 hasConcept C120665830 @default.
• W4386965450 hasConcept C121332964 @default.
• W4386965450 hasConcept C145081991 @default.
• W4386965450 hasConcept C150194340 @default.
• W4386965450 hasConcept C202751555 @default.
• W4386965450 hasConcept C207001950 @default.
• W4386965450 hasConcept C2780917455 @default.
• W4386965450 hasConcept C4907923 @default.
• W4386965450 hasConcept C520434653 @default.
• W4386965450 hasConcept C54355233 @default.
• W4386965450 hasConcept C86803240 @default.
• W4386965450 hasConcept C89423630 @default.
• W4386965450 hasConcept C90080823 @default.
• W4386965450 hasConcept C95444343 @default.
• W4386965450 hasConceptScore W4386965450C104317684 @default.
• W4386965450 hasConceptScore W4386965450C120665830 @default.
• W4386965450 hasConceptScore W4386965450C121332964 @default.
• W4386965450 hasConceptScore W4386965450C145081991 @default.
• W4386965450 hasConceptScore W4386965450C150194340 @default.
• W4386965450 hasConceptScore W4386965450C202751555 @default.
• W4386965450 hasConceptScore W4386965450C207001950 @default.
• W4386965450 hasConceptScore W4386965450C2780917455 @default.
• W4386965450 hasConceptScore W4386965450C4907923 @default.
• W4386965450 hasConceptScore W4386965450C520434653 @default.
• W4386965450 hasConceptScore W4386965450C54355233 @default.
• W4386965450 hasConceptScore W4386965450C86803240 @default.
• W4386965450 hasConceptScore W4386965450C89423630 @default.
• W4386965450 hasConceptScore W4386965450C90080823 @default.
• W4386965450 hasConceptScore W4386965450C95444343 @default.
• W4386965450 hasLocation W43869654501 @default.
• W4386965450 hasLocation W43869654502 @default.
• W4386965450 hasOpenAccess W4386965450 @default.
• W4386965450 hasPrimaryLocation W43869654501 @default.
• W4386965450 hasRelatedWork W1971063813 @default.
• W4386965450 hasRelatedWork W2153770269 @default.
• W4386965450 hasRelatedWork W2204142061 @default.
• W4386965450 hasRelatedWork W2768808834 @default.
• W4386965450 hasRelatedWork W2790178833 @default.
• W4386965450 hasRelatedWork W2900258382 @default.
• W4386965450 hasRelatedWork W2948513468 @default.
• W4386965450 hasRelatedWork W3184333097 @default.
• W4386965450 hasRelatedWork W4220824898 @default.
• W4386965450 hasRelatedWork W4300690271 @default.
• W4386965450 isParatext "false" @default.
• W4386965450 isRetracted "false" @default.
• W4386965450 workType "article" @default.