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• W4386968972 abstract "Contacts of patients with multidrug-resistant tuberculosis (MDR-TB) are at risk of developing TB disease. Tuberculosis preventive treatment (TPT) is an intervention that can potentially reduce this risk.To evaluate the effectiveness and safety of TPT for contacts of MDR-TB patients.EMBASE, PubMed, Web of Science, and the Cochrane Library were searched for eligible studies on July 24, 2023, without start date restrictions.We included studies that compared TPT with no treatment in contacts of MDR-TB patients and reported outcomes of progression to TB disease.Contacts of MDR-TB patients.TPT.A modified version of the Newcastle-Ottawa Scale was used.Random-effects meta-analysis was utilized to calculate the relative risk (RR) for disease progression to TB in contacts of MDR-TB patients who received TPT compared to those who did not. Additionally, completion, adverse effect, and discontinued rates were assessed.Involving 1105 individuals from eleven studies, the pooled RR for disease progression in contacts receiving TPT versus those without treatment was 0.34 (95% CI: 0.16-0.72). Subgroup analysis indicated a lower pooled RR for regimens based on the drug-resistance profile of the index TB patients compared to uniform treatment regimens (0.22 [95% CI: 0.06-0.84] vs. 0.49 [95% CI: 0.17-1.35]), although not statistically significant. The pooled completed rate was 83.8%, adverse effect rate was 22.9%, and discontinued rate was 6.5%. After excluding the levofloxacin and pyrazinamide regimen study, the completed rate increased to 88.0%, and adverse effects and discontinued rates decreased to 8.0% and 4.0%, respectively.TPT reduces TB disease progression risk in contacts of MDR-TB patients. Tailored TPT regimens based on drug-resistance profiles may offer additional benefits. Furthermore, efforts to improve completed rates and manage adverse effects are essential for optimizing effectiveness and safety." @default.
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• W4386968972 date "2023-09-01" @default.
• W4386968972 modified "2023-09-30" @default.
• W4386968972 title "Effectiveness and safety of tuberculosis preventive treatment for contacts of multidrug-resistant tuberculosis patients: A systematic review and Meta-analysis" @default.
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• W4386968972 doi "https://doi.org/10.1016/j.cmi.2023.09.015" @default.
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