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- W4386969349 abstract "Bradykinin has a wide variety of physiological functions, including vasodilation and blood pressure reduction. However, the physiological roles of bradykinin are not fully understood. We used the CRISPR/Cas9 method to generate BKdelK1 and BKdelK2 mutant mice, targeting the BK portion of mouse kininogen1 and kininogen2 genes, respectively. The BKdelK1 and BKdelK2 mutant mice had about 50% reductions in plasma low molecular weight kininogen and trypsin-released BK, compared to wild mice. Both BKdelK1 and BKdelK2 mice had significantly elevated systolic blood pressure compared to WT mice. These results suggest that plasma LKNG is a source of KNG in the vascular kallikrein-kinin system and contributes to maintaining lower systolic blood pressure." @default.
- W4386969349 created "2023-09-23" @default.
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- W4386969349 date "2023-11-01" @default.
- W4386969349 modified "2023-10-14" @default.
- W4386969349 title "Bradykinin deficiency causes high blood pressure in mice" @default.
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- W4386969349 doi "https://doi.org/10.1016/j.bbrc.2023.09.059" @default.
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