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- W4386975494 abstract "Osteochondral (OC) damage resulting from trauma or osteoarthritis is a common joint disorder rendering reduced quality of life and disability globally. The limited self-repair ability of cartilage and the sophisticated hierarchical microarchitecture of the OC tissue makes its repair even more challenging. Conventional therapies are mostly focused on relieving pain and improving the working of the affected joint, with no long-term functional regeneration of the OC tissue. Of late, tissue engineering has garnered much attention for OC tissue repair with a special focus on the use of appropriate biomaterial and matrices. Toward this, silk hydrogels have been extensively explored owing to their suitable microstructure, biomimetic microenvironment, and ability to encapsulate different cells and bioactive materials for sustained and controlled delivery to the defect site. This chapter provides an overview of silk-based hydrogels for OC tissue repair via the delivery of cells and bioactive molecules. Silk hydrogels in different designs such as injectable, biphasic, gradient, and reinforced hydrogels have been discussed in detail. Furthermore, we have also deliberated the recent advancements in biofabrication techniques in terms of hydrogel design and development concerning OC tissue along with its challenges and future perspective. Altogether, silk hydrogels pave various avenues for OC tissue repair with immense potential toward its translation to clinics and the healthcare market in the near future." @default.
- W4386975494 created "2023-09-23" @default.
- W4386975494 creator A5001567122 @default.
- W4386975494 creator A5014552541 @default.
- W4386975494 creator A5024399247 @default.
- W4386975494 creator A5089180739 @default.
- W4386975494 date "2024-01-01" @default.
- W4386975494 modified "2023-09-29" @default.
- W4386975494 title "Silk hydrogel-based delivery of cell and bioactive molecules for osteochondral tissue engineering applications" @default.
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- W4386975494 doi "https://doi.org/10.1016/b978-0-12-823948-3.00037-3" @default.
- W4386975494 hasPublicationYear "2024" @default.
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