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- W4386977386 abstract "The phylum Nucleocytoviricota includes the largest and most complex viruses known. These giant viruses have a long evolutionary history that dates back to the early diversification of eukaryotes, and over time they have evolved elaborate strategies for manipulating the physiology of their hosts during infection. One of the most captivating of these mechanisms involves the use of genes acquired from the host - referred to here as viral homologs or virologs - as a means of promoting viral propagation. The best-known examples of these are involved in mimicry, in which viral machinery imitates immunomodulatory elements in the vertebrate defense system. But recent findings have highlighted a vast and rapidly expanding array of other virologs that include many genes not typically found in viruses, such as those involved in translation, central carbon metabolism, cytoskeletal structure, nutrient transport, vesicular trafficking, and light harvesting. Unraveling the roles of virologs during infection as well as the evolutionary pathways through which complex functional repertoires are acquired by viruses are important frontiers at the forefront of giant virus research." @default.
- W4386977386 created "2023-09-23" @default.
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- W4386977386 date "2023-09-22" @default.
- W4386977386 modified "2023-10-06" @default.
- W4386977386 title "Virologs, viral mimicry, and virocell metabolism: The expanding scale of cellular functions encoded in the complex genomes of giant viruses" @default.
- W4386977386 doi "https://doi.org/10.1093/femsre/fuad053" @default.
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