FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386979638> ?p ?o ?g. }

• W4386979638 abstract "Chromatin remodellers are among the most important risk genes associated with neurodevelopmental disorders (NDDs), however, their functions during brain development are not fully understood. Here, we focused on Sifrim-Hitz-Weiss Syndrome (SIHIWES)-an intellectual disability disorder caused by mutations in the CHD4 chromodomain helicase gene. We utilized mouse genetics to excise the Chd4 ATPase/helicase domain-either constitutively, or conditionally in the developing telencephalon. Conditional heterozygotes exhibited no change in cortical size and cellular composition and had only subtle behavioral phenotypes. Telencephalon-specific conditional knockouts had marked reductions in cortical growth, reduced numbers of upper-layer neurons, and exhibited alterations in anxiety and repetitive behaviors. Despite the fact that whole-body heterozygotes exhibited comparable growth defects, they were unaffected in these behaviors, but instead exhibited female-specific alterations in learning and memory. These data reveal unexpected phenotypic divergence arising from differences in the spatiotemporal deployment of loss-of-function manipulations, underscoring the importance of context in chromatin remodeller function during neurodevelopment." @default.
• W4386979638 created "2023-09-24" @default.
• W4386979638 creator A5050780754 @default.
• W4386979638 creator A5070395152 @default.
• W4386979638 creator A5089444515 @default.
• W4386979638 date "2023-09-21" @default.
• W4386979638 modified "2023-10-11" @default.
• W4386979638 title "Divergent phenotypes in constitutive versus conditional mutant mouse models of Sifrim-Hitz-Weiss syndrome" @default.
• W4386979638 cites W1567517848 @default.
• W4386979638 cites W1968963646 @default.
• W4386979638 cites W1969386224 @default.
• W4386979638 cites W1973672022 @default.
• W4386979638 cites W2001381614 @default.
• W4386979638 cites W2017702380 @default.
• W4386979638 cites W2054356301 @default.
• W4386979638 cites W2074380974 @default.
• W4386979638 cites W2088229389 @default.
• W4386979638 cites W2097496333 @default.
• W4386979638 cites W2132053987 @default.
• W4386979638 cites W2162423225 @default.
• W4386979638 cites W2213332789 @default.
• W4386979638 cites W2462176300 @default.
• W4386979638 cites W2500269539 @default.
• W4386979638 cites W2520557077 @default.
• W4386979638 cites W2546675038 @default.
• W4386979638 cites W2614855056 @default.
• W4386979638 cites W2772607607 @default.
• W4386979638 cites W2798066155 @default.
• W4386979638 cites W2803671769 @default.
• W4386979638 cites W2810051411 @default.
• W4386979638 cites W2899420465 @default.
• W4386979638 cites W2946082305 @default.
• W4386979638 cites W2955503846 @default.
• W4386979638 cites W2966669081 @default.
• W4386979638 cites W2972214124 @default.
• W4386979638 cites W2994812471 @default.
• W4386979638 cites W3000679810 @default.
• W4386979638 cites W3040311946 @default.
• W4386979638 cites W3041221842 @default.
• W4386979638 cites W3157692177 @default.
• W4386979638 cites W3159421809 @default.
• W4386979638 cites W4206026336 @default.
• W4386979638 cites W4224608771 @default.
• W4386979638 cites W4225830027 @default.
• W4386979638 doi "https://doi.org/10.1093/hmg/ddad157" @default.
• W4386979638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37738575" @default.
• W4386979638 hasPublicationYear "2023" @default.
• W4386979638 type Work @default.
• W4386979638 citedByCount "0" @default.
• W4386979638 crossrefType "journal-article" @default.
• W4386979638 hasAuthorship W4386979638A5050780754 @default.
• W4386979638 hasAuthorship W4386979638A5070395152 @default.
• W4386979638 hasAuthorship W4386979638A5089444515 @default.
• W4386979638 hasConcept C104317684 @default.
• W4386979638 hasConcept C127716648 @default.
• W4386979638 hasConcept C151730666 @default.
• W4386979638 hasConcept C161223559 @default.
• W4386979638 hasConcept C164659718 @default.
• W4386979638 hasConcept C169760540 @default.
• W4386979638 hasConcept C179138559 @default.
• W4386979638 hasConcept C2779343474 @default.
• W4386979638 hasConcept C54355233 @default.
• W4386979638 hasConcept C67705224 @default.
• W4386979638 hasConcept C68838962 @default.
• W4386979638 hasConcept C77957584 @default.
• W4386979638 hasConcept C83640560 @default.
• W4386979638 hasConcept C86803240 @default.
• W4386979638 hasConceptScore W4386979638C104317684 @default.
• W4386979638 hasConceptScore W4386979638C127716648 @default.
• W4386979638 hasConceptScore W4386979638C151730666 @default.
• W4386979638 hasConceptScore W4386979638C161223559 @default.
• W4386979638 hasConceptScore W4386979638C164659718 @default.
• W4386979638 hasConceptScore W4386979638C169760540 @default.
• W4386979638 hasConceptScore W4386979638C179138559 @default.
• W4386979638 hasConceptScore W4386979638C2779343474 @default.
• W4386979638 hasConceptScore W4386979638C54355233 @default.
• W4386979638 hasConceptScore W4386979638C67705224 @default.
• W4386979638 hasConceptScore W4386979638C68838962 @default.
• W4386979638 hasConceptScore W4386979638C77957584 @default.
• W4386979638 hasConceptScore W4386979638C83640560 @default.
• W4386979638 hasConceptScore W4386979638C86803240 @default.
• W4386979638 hasFunder F4320306147 @default.
• W4386979638 hasFunder F4320319952 @default.
• W4386979638 hasFunder F4320334506 @default.
• W4386979638 hasFunder F4320334593 @default.
• W4386979638 hasLocation W43869796381 @default.
• W4386979638 hasLocation W43869796382 @default.
• W4386979638 hasOpenAccess W4386979638 @default.
• W4386979638 hasPrimaryLocation W43869796381 @default.
• W4386979638 hasRelatedWork W1989514551 @default.
• W4386979638 hasRelatedWork W2073097554 @default.
• W4386979638 hasRelatedWork W2079479353 @default.
• W4386979638 hasRelatedWork W2347872000 @default.
• W4386979638 hasRelatedWork W2369646821 @default.
• W4386979638 hasRelatedWork W2412234206 @default.
• W4386979638 hasRelatedWork W2623300151 @default.
• W4386979638 hasRelatedWork W3183838826 @default.
• W4386979638 hasRelatedWork W3208959236 @default.
• W4386979638 hasRelatedWork W4386894844 @default.
• W4386979638 isParatext "false" @default.

• next