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- W4386979805 abstract "Abstract Modulating the inflammatory microenvironment can inhibit the process of inflammatory diseases (IDs). A tri‐cross‐linked inflammatory microenvironment‐responsive hydrogel with ideal mechanical properties achieves triggerable and sustained drug delivery and regulates the inflammatory microenvironment. Here, this study develops an inflammatory microenvironment‐responsive hydrogel (OD‐PP@SeNPs) composed of phenylboronic acid grafted polylysine (PP), oxidized dextran (OD), and selenium nanoparticles (SeNPs). The introduction of SeNPs as initiators and nano‐fillers into the hydrogel results in extra cross‐linking of the polymer network through hydrogen bonding. Based on Schiff base bonds, Phenylboronate ester bonds, and hydrogen bonds, a reactive oxygen species (ROS)/pH dual responsive hydrogel with a triple‐network is achieved. The hydrogel has injectable, self‐healing, adhesion, outstanding flexibility, suitable swelling capacity, optimal biodegradability, excellent stimuli‐responsive active substance release performance, and prominent biocompatibility. Most importantly, the hydrogel with ROS scavenging and pH‐regulating ability protects cells from oxidative stress and induces macrophages into M2 polarization to reduce inflammatory cytokines through PI3K/AKT/NF‐κB and MAPK pathways, exerting anti‐inflammatory effects and reshaping the inflammatory microenvironment, thereby effectively treating typical IDs, including S. aureus infected wound and rheumatoid arthritis in rats. In conclusion, this dynamically responsive injectable hydrogel with a triple‐network structure provides an effective strategy to treat IDs, holding great promise in clinical application." @default.
- W4386979805 created "2023-09-24" @default.
- W4386979805 creator A5001081386 @default.
- W4386979805 creator A5024693956 @default.
- W4386979805 creator A5028296024 @default.
- W4386979805 creator A5029852984 @default.
- W4386979805 creator A5038635529 @default.
- W4386979805 creator A5040190187 @default.
- W4386979805 creator A5047572627 @default.
- W4386979805 creator A5057729209 @default.
- W4386979805 creator A5058016614 @default.
- W4386979805 creator A5066174435 @default.
- W4386979805 creator A5073607166 @default.
- W4386979805 creator A5075257104 @default.
- W4386979805 date "2023-09-22" @default.
- W4386979805 modified "2023-10-18" @default.
- W4386979805 title "Triple Cross‐linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF‐κB and MAPK Signaling Pathways" @default.
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