Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386980427> ?p ?o ?g. }
- W4386980427 abstract "Despite decades of laboratory and clinical trials, breast cancer remains the main cause of cancer-related disease burden in women. Considering the metabolism destruction effect of metformin (Met) and cancer cell starvation induced by glucose oxidase (GOx), after their efficient delivery to tumor sites, GOx and Met may consume a large amount of glucose and produce sufficient hydrogen peroxide in situ. Herein, a pH-responsive epigallocatechin gallate (EGCG)-conjugated low-molecular-weight chitosan (LC-EGCG, LE) nanoplatform (Met-GOx/Fe@LE NPs) was constructed. The coordination between iron ions (Fe3+) and EGCG in this nanoplatform can enhance the efficacy of chemodynamic therapy via the Fenton reaction. Met-GOx/Fe@LE NPs allow GOx to retain its enzymatic activity while simultaneously improving its stability. Moreover, this pH-responsive nanoplatform presents controllable drug release behavior. An in vivo biodistribution study showed that the intracranial accumulation of GOx delivered by this nanoplatform was 3.6-fold higher than that of the free drug. The in vivo anticancer results indicated that this metabolism destruction/starvation/chemodynamic triple-combination therapy could induce increased apoptosis/death of tumor cells and reduce their proliferation. This triple-combination therapy approach is promising for efficient and targeted cancer treatment." @default.
- W4386980427 created "2023-09-24" @default.
- W4386980427 creator A5006242706 @default.
- W4386980427 creator A5009606065 @default.
- W4386980427 creator A5043774998 @default.
- W4386980427 creator A5044668630 @default.
- W4386980427 creator A5075760601 @default.
- W4386980427 creator A5076805193 @default.
- W4386980427 creator A5078512784 @default.
- W4386980427 date "2023-09-01" @default.
- W4386980427 modified "2023-10-18" @default.
- W4386980427 title "Enhancing metformin-induced tumor metabolism destruction by glucose oxidase for triple-combination therapy" @default.
- W4386980427 cites W2029667189 @default.
- W4386980427 cites W2044884910 @default.
- W4386980427 cites W2121618836 @default.
- W4386980427 cites W2132525235 @default.
- W4386980427 cites W2153771870 @default.
- W4386980427 cites W2320164150 @default.
- W4386980427 cites W2605327520 @default.
- W4386980427 cites W2734856592 @default.
- W4386980427 cites W2888802947 @default.
- W4386980427 cites W2899114650 @default.
- W4386980427 cites W2943331511 @default.
- W4386980427 cites W2975897071 @default.
- W4386980427 cites W3000356232 @default.
- W4386980427 cites W3008039096 @default.
- W4386980427 cites W3011754995 @default.
- W4386980427 cites W3023756597 @default.
- W4386980427 cites W3036210700 @default.
- W4386980427 cites W3093572315 @default.
- W4386980427 cites W3095397570 @default.
- W4386980427 cites W3120903220 @default.
- W4386980427 cites W3122352939 @default.
- W4386980427 cites W3126550244 @default.
- W4386980427 cites W3132508197 @default.
- W4386980427 cites W3134059314 @default.
- W4386980427 cites W3139239834 @default.
- W4386980427 cites W3146846907 @default.
- W4386980427 cites W3175063213 @default.
- W4386980427 cites W3184431805 @default.
- W4386980427 cites W3191658494 @default.
- W4386980427 cites W3206395974 @default.
- W4386980427 cites W3214581967 @default.
- W4386980427 cites W4205845008 @default.
- W4386980427 cites W4206718515 @default.
- W4386980427 cites W4210370823 @default.
- W4386980427 cites W4213300558 @default.
- W4386980427 cites W4213373273 @default.
- W4386980427 cites W4220905968 @default.
- W4386980427 cites W4220984108 @default.
- W4386980427 cites W4221040691 @default.
- W4386980427 cites W4223542607 @default.
- W4386980427 cites W4223596573 @default.
- W4386980427 cites W4225310476 @default.
- W4386980427 cites W4229026436 @default.
- W4386980427 cites W4280645323 @default.
- W4386980427 cites W4285184615 @default.
- W4386980427 cites W4285735370 @default.
- W4386980427 cites W4289262737 @default.
- W4386980427 cites W4291002583 @default.
- W4386980427 cites W4291136030 @default.
- W4386980427 cites W4292457870 @default.
- W4386980427 cites W4293175913 @default.
- W4386980427 cites W4306729018 @default.
- W4386980427 cites W4308890609 @default.
- W4386980427 cites W4317935787 @default.
- W4386980427 cites W4321349126 @default.
- W4386980427 cites W4361214957 @default.
- W4386980427 doi "https://doi.org/10.1016/j.jpha.2023.09.015" @default.
- W4386980427 hasPublicationYear "2023" @default.
- W4386980427 type Work @default.
- W4386980427 citedByCount "0" @default.
- W4386980427 crossrefType "journal-article" @default.
- W4386980427 hasAuthorship W4386980427A5006242706 @default.
- W4386980427 hasAuthorship W4386980427A5009606065 @default.
- W4386980427 hasAuthorship W4386980427A5043774998 @default.
- W4386980427 hasAuthorship W4386980427A5044668630 @default.
- W4386980427 hasAuthorship W4386980427A5075760601 @default.
- W4386980427 hasAuthorship W4386980427A5076805193 @default.
- W4386980427 hasAuthorship W4386980427A5078512784 @default.
- W4386980427 hasBestOaLocation W43869804271 @default.
- W4386980427 hasConcept C121608353 @default.
- W4386980427 hasConcept C126322002 @default.
- W4386980427 hasConcept C150903083 @default.
- W4386980427 hasConcept C17093226 @default.
- W4386980427 hasConcept C181199279 @default.
- W4386980427 hasConcept C185592680 @default.
- W4386980427 hasConcept C190283241 @default.
- W4386980427 hasConcept C207001950 @default.
- W4386980427 hasConcept C2776999253 @default.
- W4386980427 hasConcept C2777197210 @default.
- W4386980427 hasConcept C2779306644 @default.
- W4386980427 hasConcept C2780323712 @default.
- W4386980427 hasConcept C31573885 @default.
- W4386980427 hasConcept C502942594 @default.
- W4386980427 hasConcept C533411734 @default.
- W4386980427 hasConcept C55493867 @default.
- W4386980427 hasConcept C71924100 @default.
- W4386980427 hasConcept C86803240 @default.
- W4386980427 hasConcept C96232424 @default.