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- W4386981036 endingPage "171" @default.
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- W4386981036 abstract "The process of drug discovery and development encompasses target identification, validation, assay development, identification of hits, lead optimization, preclinical evaluation, and finally human clinical trials. Once a new chemical entity (NCE) is discovered, it progresses toward the development process that includes preclinical and clinical pharmacology. Preclinical research includes in silico, in vitro, ex vivo, and in vivo studies using cell lines, tissues, and animal models for predicting pharmacokinetic and pharmacodynamic properties of lead candidates. In vivo studies are critical in the drug development process because these investigations are useful to assess the properties of drugs and physiological and biochemical processes like adverse drug reactions and drug-drug interactions, which are difficult to examine in vitro. This chapter provides the detailed insight on in vivo studies that includes animal models and toxicology testing methodologies to identify a safe, potent, and efficacious drug. This chapter also highlights the importance of predictive and validated animal models for absorption, distribution, metabolism, and excretion (ADME) studies, along with the disease-based animal models for understanding disease pathophysiology that ultimately helps in making decisions that lead to human clinical trials for a drug candidate." @default.
- W4386981036 created "2023-09-24" @default.
- W4386981036 creator A5003374144 @default.
- W4386981036 creator A5017801713 @default.
- W4386981036 creator A5056811288 @default.
- W4386981036 date "2023-01-01" @default.
- W4386981036 modified "2023-10-01" @default.
- W4386981036 title "Preclinical In Vivo Drug Development Studies: Limitations, Model Organisms, and Techniques" @default.
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- W4386981036 doi "https://doi.org/10.1007/978-981-19-7952-1_6" @default.
- W4386981036 hasPublicationYear "2023" @default.