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- W4386981141 abstract "Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis and is the second leading reason of death worldwide from infectious diseases after HIV. Available anti-TB chemotherapy requires a cocktail of several drugs for more than 6 months. Due to the rise of extensively and multidrug-resistant strains of Mtb along with HIV co-infection, there is an urgent need of new molecules for the TB treatment. These new drug molecules must have a novel mode of action and low toxicity profile, is active against both susceptible and drug-resistant strains of Mtb, should be well tolerated in combination with antiretroviral drugs, and more importantly shall require lesser time to clear the infection. The pathology of Mtb and its ability to adapt and survive in heterogeneous states inside the host during infection are the major challenges in anti-TB drug discovery. Therefore, various high-throughput screening (HTS) methods that mimic closely to the host conditions during Mtb infection can be used to identify novel drug molecules. This chapter summarizes these HTS methods for discovering novel anti-TB molecules." @default.
- W4386981141 created "2023-09-24" @default.
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- W4386981141 date "2023-01-01" @default.
- W4386981141 modified "2023-10-18" @default.
- W4386981141 title "Perspectives on Anti-Tuberculosis Drug Discovery" @default.
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- W4386981141 doi "https://doi.org/10.1007/978-981-19-7952-1_13" @default.
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