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- W4386985648 abstract "Abstract Whole-brain simulations have been proposed previously to simulate global properties such as brain states or functional connectivity. Here, our aim is to build a whole-brain model to simulate a simple cognitive paradigm involving multiple brain areas. We focus on auditory discrimination, using a paradigm designed for the macaque cortex. To model at the whole-brain scale, we use The Virtual Brain (TVB) [18] simulation environment. TVB is a computational framework which simulates the brain as a network of small brain regions, where each node models neuronal populations and the connectivity between nodes determines the pathway of information flow over the brain. We use Adaptive Exponential (AdEx) neuronal population models [4, 11] to describe each node. For the connectivity, we use the open-access CoCoMac connectivity dataset [2], which is a matrix containing the connection weights between the nodes. We focus on a cognitive task that mainly involves the prefrontal cortex (PFC). In the auditory discrimination task, our pipeline starts from the primary auditory cortex stimulated by the auditory signals, it is then modulated in the PFC so that the stimulus discrimination occurs, after competition. Finally, it ends in the primary motor cortex which outputs the neuronal activity determining the motor action. Because the AdEx mean-fields can provide access to neuronal activity or local field potentials, we think that the present model constitutes a useful tool to promote interactions between theory and experiments for simple cognitive tasks in macaque monkey." @default.
- W4386985648 created "2023-09-24" @default.
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- W4386985648 date "2023-09-23" @default.
- W4386985648 modified "2023-10-11" @default.
- W4386985648 title "A whole-brain model of auditory discrimination" @default.
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- W4386985648 doi "https://doi.org/10.1101/2023.09.23.559095" @default.
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