Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386987333> ?p ?o ?g. }
- W4386987333 endingPage "166894" @default.
- W4386987333 startingPage "166894" @default.
- W4386987333 abstract "The occurrence of colorectal cancer (CRC) is inversely correlated with estrogen receptor beta (ERβ) presence. Additionally, multiple studies associate low ERβ expression with poorer overall survival of CRC patients. Molecular pathways involved in ERβ - related reduced tumorigenesis include enhanced apoptosis, decreased proliferation, or repression of oncogenes. Moreover, the development of solid tumors, such as CRC, is often associated with an increased tumor mass that results in decreased oxygen partial tension, known as hypoxia, clinically associated with decreased prognosis and therapeutic resistance. Our high-throughput study suggests that ERβ also represses a hypoxic response in CRC cells. We observed a significantly altered transcriptional profile in HCT116 ERβ overexpressing cells that was further stimulated by E2 treatment under hypoxic conditions. The achieved data for downregulation of VEGFA, PDGFA and ANGPTL4 were validated in a time course experiment in DLD-1 cells. In addition, using an ERβ construct with a mutated DNA binding domain we observed that the downregulation of selected genes is dependent on the direct binding of this receptor to regulatory region genes. In addition, we observed that ERβ may affect the expression of the main hypoxia regulator, HIF1A, at the transcriptional and translational levels. In summary, ERβ alters the hypoxic outcome in CRC cells." @default.
- W4386987333 created "2023-09-24" @default.
- W4386987333 creator A5004800411 @default.
- W4386987333 creator A5017288293 @default.
- W4386987333 creator A5021873567 @default.
- W4386987333 creator A5029056478 @default.
- W4386987333 creator A5034874180 @default.
- W4386987333 creator A5049624300 @default.
- W4386987333 creator A5065649258 @default.
- W4386987333 creator A5081102916 @default.
- W4386987333 creator A5089180685 @default.
- W4386987333 date "2024-01-01" @default.
- W4386987333 modified "2023-10-09" @default.
- W4386987333 title "Estrogen receptor β affects hypoxia response in colorectal cancer cells" @default.
- W4386987333 cites W1564796335 @default.
- W4386987333 cites W1736447480 @default.
- W4386987333 cites W1991455388 @default.
- W4386987333 cites W1994734085 @default.
- W4386987333 cites W2003639182 @default.
- W4386987333 cites W2015987142 @default.
- W4386987333 cites W2018235415 @default.
- W4386987333 cites W2020490227 @default.
- W4386987333 cites W2035618305 @default.
- W4386987333 cites W2035983112 @default.
- W4386987333 cites W2040051713 @default.
- W4386987333 cites W2061805003 @default.
- W4386987333 cites W2087377825 @default.
- W4386987333 cites W2100773081 @default.
- W4386987333 cites W2101013822 @default.
- W4386987333 cites W2109612144 @default.
- W4386987333 cites W2116397033 @default.
- W4386987333 cites W2116634113 @default.
- W4386987333 cites W2121288523 @default.
- W4386987333 cites W2122683221 @default.
- W4386987333 cites W2126592654 @default.
- W4386987333 cites W2127654933 @default.
- W4386987333 cites W2132859686 @default.
- W4386987333 cites W2146512944 @default.
- W4386987333 cites W2151029652 @default.
- W4386987333 cites W2151123562 @default.
- W4386987333 cites W2151806794 @default.
- W4386987333 cites W2157426972 @default.
- W4386987333 cites W2161491874 @default.
- W4386987333 cites W2163325952 @default.
- W4386987333 cites W2166290677 @default.
- W4386987333 cites W2176496044 @default.
- W4386987333 cites W2185207072 @default.
- W4386987333 cites W2210107480 @default.
- W4386987333 cites W2551761845 @default.
- W4386987333 cites W2769024706 @default.
- W4386987333 cites W2771191755 @default.
- W4386987333 cites W2924885341 @default.
- W4386987333 cites W2932465313 @default.
- W4386987333 cites W2971690844 @default.
- W4386987333 cites W3045200208 @default.
- W4386987333 cites W3094559596 @default.
- W4386987333 cites W3127344393 @default.
- W4386987333 cites W3139245272 @default.
- W4386987333 cites W4211204046 @default.
- W4386987333 cites W4294216491 @default.
- W4386987333 cites W4309154442 @default.
- W4386987333 cites W4310222802 @default.
- W4386987333 cites W4323318843 @default.
- W4386987333 cites W4323320156 @default.
- W4386987333 doi "https://doi.org/10.1016/j.bbadis.2023.166894" @default.
- W4386987333 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37748565" @default.
- W4386987333 hasPublicationYear "2024" @default.
- W4386987333 type Work @default.
- W4386987333 citedByCount "0" @default.
- W4386987333 crossrefType "journal-article" @default.
- W4386987333 hasAuthorship W4386987333A5004800411 @default.
- W4386987333 hasAuthorship W4386987333A5017288293 @default.
- W4386987333 hasAuthorship W4386987333A5021873567 @default.
- W4386987333 hasAuthorship W4386987333A5029056478 @default.
- W4386987333 hasAuthorship W4386987333A5034874180 @default.
- W4386987333 hasAuthorship W4386987333A5049624300 @default.
- W4386987333 hasAuthorship W4386987333A5065649258 @default.
- W4386987333 hasAuthorship W4386987333A5081102916 @default.
- W4386987333 hasAuthorship W4386987333A5089180685 @default.
- W4386987333 hasBestOaLocation W43869873331 @default.
- W4386987333 hasConcept C104317684 @default.
- W4386987333 hasConcept C121608353 @default.
- W4386987333 hasConcept C126322002 @default.
- W4386987333 hasConcept C127561419 @default.
- W4386987333 hasConcept C134018914 @default.
- W4386987333 hasConcept C170493617 @default.
- W4386987333 hasConcept C172313692 @default.
- W4386987333 hasConcept C178790620 @default.
- W4386987333 hasConcept C185592680 @default.
- W4386987333 hasConcept C2777164284 @default.
- W4386987333 hasConcept C2780394083 @default.
- W4386987333 hasConcept C2993207723 @default.
- W4386987333 hasConcept C31194975 @default.
- W4386987333 hasConcept C502942594 @default.
- W4386987333 hasConcept C526805850 @default.
- W4386987333 hasConcept C530470458 @default.
- W4386987333 hasConcept C540031477 @default.
- W4386987333 hasConcept C54355233 @default.