Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386987626> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4386987626 endingPage "113569" @default.
- W4386987626 startingPage "113569" @default.
- W4386987626 abstract "Biologic drugs (therapeutic proteins or peptides) have become one of the most important therapeutic modalities over the past few decades. Drug-induced immunogenicity is a significant concern as it may affect safety, tolerability, and efficacy. With more sensitive and drug-tolerant screening assays in use today, reliable estimation of anti-drug-antibody (ADA) titer has become more important for understanding clinically relevant ADA levels. Titer is commonly defined as the dilution factor resulting in an assay signal equal to a pre-specified cut point factor. Given its influence on the resulting titer precision, the choice of a titer cut point factor warrants careful consideration. In this paper, we discuss the theoretical dilution model, investigate how titer variability depends on the cut point factor and propose a standardized cut point factor to increase precision of titer estimates. Additionally, we demonstrate that non-linear regression-based titer estimation provides both improved precision and implementation efficiency relative to commonly used estimation approaches." @default.
- W4386987626 created "2023-09-24" @default.
- W4386987626 creator A5021199853 @default.
- W4386987626 creator A5031924062 @default.
- W4386987626 creator A5047470866 @default.
- W4386987626 creator A5051170290 @default.
- W4386987626 creator A5052240068 @default.
- W4386987626 creator A5063637099 @default.
- W4386987626 creator A5077682540 @default.
- W4386987626 date "2023-11-01" @default.
- W4386987626 modified "2023-09-30" @default.
- W4386987626 title "A systematic examination of anti-drug antibody titer estimation: Applied recommendations" @default.
- W4386987626 cites W1541495102 @default.
- W4386987626 cites W1966214235 @default.
- W4386987626 cites W1970942128 @default.
- W4386987626 cites W1997819698 @default.
- W4386987626 cites W2039680788 @default.
- W4386987626 cites W2046974419 @default.
- W4386987626 cites W2069506532 @default.
- W4386987626 cites W2128056712 @default.
- W4386987626 cites W2761129209 @default.
- W4386987626 cites W3083926655 @default.
- W4386987626 doi "https://doi.org/10.1016/j.jim.2023.113569" @default.
- W4386987626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37748729" @default.
- W4386987626 hasPublicationYear "2023" @default.
- W4386987626 type Work @default.
- W4386987626 citedByCount "0" @default.
- W4386987626 crossrefType "journal-article" @default.
- W4386987626 hasAuthorship W4386987626A5021199853 @default.
- W4386987626 hasAuthorship W4386987626A5031924062 @default.
- W4386987626 hasAuthorship W4386987626A5047470866 @default.
- W4386987626 hasAuthorship W4386987626A5051170290 @default.
- W4386987626 hasAuthorship W4386987626A5052240068 @default.
- W4386987626 hasAuthorship W4386987626A5063637099 @default.
- W4386987626 hasAuthorship W4386987626A5077682540 @default.
- W4386987626 hasConcept C159654299 @default.
- W4386987626 hasConcept C203014093 @default.
- W4386987626 hasConcept C2780035454 @default.
- W4386987626 hasConcept C2780868878 @default.
- W4386987626 hasConcept C32611913 @default.
- W4386987626 hasConcept C71924100 @default.
- W4386987626 hasConcept C98274493 @default.
- W4386987626 hasConceptScore W4386987626C159654299 @default.
- W4386987626 hasConceptScore W4386987626C203014093 @default.
- W4386987626 hasConceptScore W4386987626C2780035454 @default.
- W4386987626 hasConceptScore W4386987626C2780868878 @default.
- W4386987626 hasConceptScore W4386987626C32611913 @default.
- W4386987626 hasConceptScore W4386987626C71924100 @default.
- W4386987626 hasConceptScore W4386987626C98274493 @default.
- W4386987626 hasLocation W43869876261 @default.
- W4386987626 hasLocation W43869876262 @default.
- W4386987626 hasOpenAccess W4386987626 @default.
- W4386987626 hasPrimaryLocation W43869876261 @default.
- W4386987626 hasRelatedWork W1591820460 @default.
- W4386987626 hasRelatedWork W1934038313 @default.
- W4386987626 hasRelatedWork W1991435963 @default.
- W4386987626 hasRelatedWork W2028450449 @default.
- W4386987626 hasRelatedWork W2074827279 @default.
- W4386987626 hasRelatedWork W2352977685 @default.
- W4386987626 hasRelatedWork W2377972480 @default.
- W4386987626 hasRelatedWork W2899193044 @default.
- W4386987626 hasRelatedWork W2953458067 @default.
- W4386987626 hasRelatedWork W4300860271 @default.
- W4386987626 hasVolume "522" @default.
- W4386987626 isParatext "false" @default.
- W4386987626 isRetracted "false" @default.
- W4386987626 workType "article" @default.