Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386988438> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W4386988438 abstract "The highly diverse T cell receptor (TCR) repertoire is a crucial component of the adaptive immune system that aids in the protection against a wide variety of pathogens. This TCR repertoire, comprising the collection of all TCRs in an individual, is a valuable source of information on both recent and ongoing T cell activation. Cancer cells, like pathogens, have the ability to trigger an adaptive immune response. However, because cancer cells use a variety of strategies to escape immune responses, this is often insufficient to completely eradicate them. As a result, immunotherapy is a promising treatment option for cancer patients. This treatment is expected to increase T cell activation and subsequently alter the TCR repertoire composition in these patients. Monitoring TCR repertoires before and after immunotherapy can therefore provide additional insight into T cell responses and might identify cancer-associated TCR sequences. Here we present a computational strategy to identify those changes in the TCR repertoire that occur after treatment with immunotherapy. Since this method allows the identification of TCR patterns that might be treatment-associated, it can help future research by revealing those patterns that are related with response. This TCR analysis workflow is illustrated using public data from three different cancer patients who received anti-PD-1 treatment." @default.
- W4386988438 created "2023-09-24" @default.
- W4386988438 creator A5023604446 @default.
- W4386988438 creator A5024401144 @default.
- W4386988438 creator A5024445778 @default.
- W4386988438 creator A5082122960 @default.
- W4386988438 date "2023-01-01" @default.
- W4386988438 modified "2023-09-29" @default.
- W4386988438 title "Identification of TCR repertoire patterns linked with anti-cancer immunotherapy" @default.
- W4386988438 cites W1483854882 @default.
- W4386988438 cites W1967867591 @default.
- W4386988438 cites W2003485639 @default.
- W4386988438 cites W2018330851 @default.
- W4386988438 cites W2084659308 @default.
- W4386988438 cites W2087189381 @default.
- W4386988438 cites W2098504116 @default.
- W4386988438 cites W2100213817 @default.
- W4386988438 cites W2163660115 @default.
- W4386988438 cites W2671261300 @default.
- W4386988438 cites W2774014537 @default.
- W4386988438 cites W2890742557 @default.
- W4386988438 cites W2985693568 @default.
- W4386988438 cites W3004207027 @default.
- W4386988438 cites W3013242650 @default.
- W4386988438 cites W3028523516 @default.
- W4386988438 cites W3082739140 @default.
- W4386988438 cites W3167871643 @default.
- W4386988438 cites W3176460341 @default.
- W4386988438 cites W3204749855 @default.
- W4386988438 cites W3206495843 @default.
- W4386988438 cites W4200374506 @default.
- W4386988438 cites W4205982804 @default.
- W4386988438 cites W4220878148 @default.
- W4386988438 cites W4242646512 @default.
- W4386988438 doi "https://doi.org/10.1016/bs.mcb.2023.05.001" @default.
- W4386988438 hasPublicationYear "2023" @default.
- W4386988438 type Work @default.
- W4386988438 citedByCount "0" @default.
- W4386988438 crossrefType "book-chapter" @default.
- W4386988438 hasAuthorship W4386988438A5023604446 @default.
- W4386988438 hasAuthorship W4386988438A5024401144 @default.
- W4386988438 hasAuthorship W4386988438A5024445778 @default.
- W4386988438 hasAuthorship W4386988438A5082122960 @default.
- W4386988438 hasConcept C121332964 @default.
- W4386988438 hasConcept C121608353 @default.
- W4386988438 hasConcept C19317047 @default.
- W4386988438 hasConcept C193419808 @default.
- W4386988438 hasConcept C203014093 @default.
- W4386988438 hasConcept C24890656 @default.
- W4386988438 hasConcept C2776090121 @default.
- W4386988438 hasConcept C2777701055 @default.
- W4386988438 hasConcept C2778473898 @default.
- W4386988438 hasConcept C2780674031 @default.
- W4386988438 hasConcept C54355233 @default.
- W4386988438 hasConcept C70721500 @default.
- W4386988438 hasConcept C86803240 @default.
- W4386988438 hasConcept C8891405 @default.
- W4386988438 hasConceptScore W4386988438C121332964 @default.
- W4386988438 hasConceptScore W4386988438C121608353 @default.
- W4386988438 hasConceptScore W4386988438C19317047 @default.
- W4386988438 hasConceptScore W4386988438C193419808 @default.
- W4386988438 hasConceptScore W4386988438C203014093 @default.
- W4386988438 hasConceptScore W4386988438C24890656 @default.
- W4386988438 hasConceptScore W4386988438C2776090121 @default.
- W4386988438 hasConceptScore W4386988438C2777701055 @default.
- W4386988438 hasConceptScore W4386988438C2778473898 @default.
- W4386988438 hasConceptScore W4386988438C2780674031 @default.
- W4386988438 hasConceptScore W4386988438C54355233 @default.
- W4386988438 hasConceptScore W4386988438C70721500 @default.
- W4386988438 hasConceptScore W4386988438C86803240 @default.
- W4386988438 hasConceptScore W4386988438C8891405 @default.
- W4386988438 hasLocation W43869884381 @default.
- W4386988438 hasOpenAccess W4386988438 @default.
- W4386988438 hasPrimaryLocation W43869884381 @default.
- W4386988438 hasRelatedWork W1994960978 @default.
- W4386988438 hasRelatedWork W202870370 @default.
- W4386988438 hasRelatedWork W2120365014 @default.
- W4386988438 hasRelatedWork W2164001237 @default.
- W4386988438 hasRelatedWork W2218274148 @default.
- W4386988438 hasRelatedWork W3170913590 @default.
- W4386988438 hasRelatedWork W4360983034 @default.
- W4386988438 hasRelatedWork W4372227954 @default.
- W4386988438 hasRelatedWork W4382679534 @default.
- W4386988438 hasRelatedWork W4386988438 @default.
- W4386988438 isParatext "false" @default.
- W4386988438 isRetracted "false" @default.
- W4386988438 workType "book-chapter" @default.