FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386988557> ?p ?o ?g. }

• W4386988557 abstract "Kaposi's sarcoma-associated herpesvirus (KSHV) is a large, oncogenic DNA virus belonging to the gammaherpesvirus subfamily. KSHV has been extensively studied with various high-throughput RNA-sequencing approaches to map the transcription start and end sites, the splice junctions, and the translation initiation sites. Despite these efforts, the comprehensive annotation of the viral transcriptome remains incomplete. In the present study, we generated a long-read sequencing dataset of the lytic and latent KSHV transcriptome using native RNA and direct cDNA sequencing methods. This was supplemented with CAGE sequencing based on a short-read platform. We also utilized datasets from previous publications for our analysis. As a result of this combined approach, we have identified a number of novel viral transcripts and RNA isoforms and have either corroborated or improved the annotation of previously identified viral RNA molecules, thereby notably enhancing our comprehension of the transcriptomic architecture of the KSHV genome. We also evaluated the coding capability of transcripts previously thought to be non-coding, by integrating our data on the viral transcripts with translatomic information from other publications.Deciphering the viral transcriptome of KSHV is of great importance because we can gain insight into the molecular mechanism of viral replication and pathogenesis, which can help develop potential targets for antiviral interventions. Specifically, the identification of substantial transcriptional overlaps by this work suggests the existence of a genome-wide interference between transcriptional machineries. This finding indicates the presence of a novel regulatory layer, potentially controlling the expression of viral genes." @default.
• W4386988557 created "2023-09-24" @default.
• W4386988557 creator A5007349976 @default.
• W4386988557 creator A5011993610 @default.
• W4386988557 creator A5016882126 @default.
• W4386988557 creator A5026162398 @default.
• W4386988557 creator A5041442917 @default.
• W4386988557 creator A5049146200 @default.
• W4386988557 creator A5049246356 @default.
• W4386988557 creator A5056796172 @default.
• W4386988557 creator A5066801087 @default.
• W4386988557 creator A5070398937 @default.
• W4386988557 date "2023-09-23" @default.
• W4386988557 modified "2023-10-18" @default.
• W4386988557 title "KSHV 3.0: A State-of-the-Art Annotation of the Kaposi's Sarcoma-Associated Herpesvirus Transcriptome Using Cross-Platform Sequencing" @default.
• W4386988557 cites W1154000798 @default.
• W4386988557 cites W1521064197 @default.
• W4386988557 cites W1532938692 @default.
• W4386988557 cites W1566845420 @default.
• W4386988557 cites W1591784261 @default.
• W4386988557 cites W1974538337 @default.
• W4386988557 cites W1978001038 @default.
• W4386988557 cites W1979681838 @default.
• W4386988557 cites W1980534226 @default.
• W4386988557 cites W1984289346 @default.
• W4386988557 cites W1992308820 @default.
• W4386988557 cites W2016353752 @default.
• W4386988557 cites W2016945496 @default.
• W4386988557 cites W2032438721 @default.
• W4386988557 cites W2041801909 @default.
• W4386988557 cites W2049174722 @default.
• W4386988557 cites W2058268968 @default.
• W4386988557 cites W2060993350 @default.
• W4386988557 cites W2064390432 @default.
• W4386988557 cites W2064640692 @default.
• W4386988557 cites W2065845491 @default.
• W4386988557 cites W2066410692 @default.
• W4386988557 cites W2068928545 @default.
• W4386988557 cites W2075485921 @default.
• W4386988557 cites W2084086052 @default.
• W4386988557 cites W2097851380 @default.
• W4386988557 cites W2100365539 @default.
• W4386988557 cites W2102274616 @default.
• W4386988557 cites W2104107907 @default.
• W4386988557 cites W2105917501 @default.
• W4386988557 cites W2123897501 @default.
• W4386988557 cites W2126182115 @default.
• W4386988557 cites W2135986967 @default.
• W4386988557 cites W2147330914 @default.
• W4386988557 cites W2152736091 @default.
• W4386988557 cites W2158043392 @default.
• W4386988557 cites W2159051688 @default.
• W4386988557 cites W2161640889 @default.
• W4386988557 cites W2161997444 @default.
• W4386988557 cites W2230709708 @default.
• W4386988557 cites W2326927401 @default.
• W4386988557 cites W2424995076 @default.
• W4386988557 cites W2467179929 @default.
• W4386988557 cites W2467833497 @default.
• W4386988557 cites W2520345180 @default.
• W4386988557 cites W2526814871 @default.
• W4386988557 cites W2560058040 @default.
• W4386988557 cites W2592218525 @default.
• W4386988557 cites W2592780432 @default.
• W4386988557 cites W2601106856 @default.
• W4386988557 cites W2775912055 @default.
• W4386988557 cites W2900792449 @default.
• W4386988557 cites W2902403702 @default.
• W4386988557 cites W2902725523 @default.
• W4386988557 cites W2905245452 @default.
• W4386988557 cites W2905476782 @default.
• W4386988557 cites W2906703216 @default.
• W4386988557 cites W2911318881 @default.
• W4386988557 cites W2917631923 @default.
• W4386988557 cites W2921621835 @default.
• W4386988557 cites W2950465644 @default.
• W4386988557 cites W2952628721 @default.
• W4386988557 cites W2953367631 @default.
• W4386988557 cites W2968557845 @default.
• W4386988557 cites W2988190876 @default.
• W4386988557 cites W2999304916 @default.
• W4386988557 cites W3000356419 @default.
• W4386988557 cites W3010062446 @default.
• W4386988557 cites W3018762673 @default.
• W4386988557 cites W3038219645 @default.
• W4386988557 cites W3038928749 @default.
• W4386988557 cites W3049144686 @default.
• W4386988557 cites W3108331775 @default.
• W4386988557 cites W3120544136 @default.
• W4386988557 cites W3132524241 @default.
• W4386988557 cites W3177221809 @default.
• W4386988557 cites W3187935049 @default.
• W4386988557 cites W4205593742 @default.
• W4386988557 cites W4206033085 @default.
• W4386988557 cites W4206112501 @default.
• W4386988557 cites W4210697428 @default.
• W4386988557 cites W4285386945 @default.
• W4386988557 cites W4306668129 @default.
• W4386988557 cites W4313830569 @default.
• W4386988557 cites W4318765064 @default.

• next