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- W4386988782 abstract "Type II diabetes mellitus (T2DM) is a chronic metabolic disease characterized by prolonged hyperglycemia and insulin resistance (IR). Its incidence is increasing annually, posing a significant threat to human life and health. Consequently, there is an urgent requirement to discover effective drugs and investigate the pathogenesis of T2DM. Autophagy plays a crucial role in maintaining normal islet structure. However, in a state of high glucose, autophagy is inhibited, resulting in impaired islet function, insulin resistance, and complications. Studies have shown that modulating autophagy through activation or inhibition can have a positive impact on the treatment of T2DM and its complications. However, it is important to note that the specific regulatory mechanisms vary depending on the target organ. This review explores the role of autophagy in the pathogenesis of T2DM, taking into account both genetic and external factors. It also provides a summary of reported chemical drugs and traditional Chinese medicine that target the autophagic pathway for the treatment of T2DM and its complications." @default.
- W4386988782 created "2023-09-24" @default.
- W4386988782 creator A5012386664 @default.
- W4386988782 creator A5016622484 @default.
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- W4386988782 creator A5059470534 @default.
- W4386988782 creator A5064221229 @default.
- W4386988782 creator A5066197284 @default.
- W4386988782 creator A5083731740 @default.
- W4386988782 creator A5085819924 @default.
- W4386988782 date "2023-09-21" @default.
- W4386988782 modified "2023-10-11" @default.
- W4386988782 title "The role of autophagy in the treatment of type II diabetes and its complications: a review" @default.
- W4386988782 cites W1125737316 @default.
- W4386988782 cites W1487257968 @default.
- W4386988782 cites W1518639300 @default.
- W4386988782 cites W1523693806 @default.
- W4386988782 cites W1645439749 @default.
- W4386988782 cites W1715909735 @default.
- W4386988782 cites W176214772 @default.
- W4386988782 cites W1909235827 @default.
- W4386988782 cites W1928930123 @default.
- W4386988782 cites W1973432709 @default.
- W4386988782 cites W1981340241 @default.
- W4386988782 cites W1988281226 @default.
- W4386988782 cites W1988747541 @default.
- W4386988782 cites W1989884692 @default.
- W4386988782 cites W1990414793 @default.
- W4386988782 cites W1991136352 @default.
- W4386988782 cites W1993458861 @default.
- W4386988782 cites W1998399313 @default.
- W4386988782 cites W1999575142 @default.
- W4386988782 cites W2001108915 @default.
- W4386988782 cites W2003402921 @default.
- W4386988782 cites W2004014076 @default.
- W4386988782 cites W2005038357 @default.
- W4386988782 cites W2006254543 @default.
- W4386988782 cites W2007505836 @default.
- W4386988782 cites W2007743440 @default.
- W4386988782 cites W2008958059 @default.
- W4386988782 cites W2016040396 @default.
- W4386988782 cites W2018559323 @default.
- W4386988782 cites W2020267609 @default.
- W4386988782 cites W2022570265 @default.
- W4386988782 cites W2026771933 @default.
- W4386988782 cites W2030287946 @default.
- W4386988782 cites W2032700869 @default.
- W4386988782 cites W2033212418 @default.
- W4386988782 cites W2037588135 @default.
- W4386988782 cites W2044687165 @default.
- W4386988782 cites W2048057768 @default.
- W4386988782 cites W2051719011 @default.
- W4386988782 cites W2057042201 @default.
- W4386988782 cites W2061166531 @default.
- W4386988782 cites W2065908325 @default.
- W4386988782 cites W2079355772 @default.
- W4386988782 cites W2080746576 @default.
- W4386988782 cites W2083656536 @default.
- W4386988782 cites W2084313039 @default.
- W4386988782 cites W2087222440 @default.
- W4386988782 cites W2089122115 @default.
- W4386988782 cites W2096317893 @default.
- W4386988782 cites W2104040600 @default.
- W4386988782 cites W2116150143 @default.
- W4386988782 cites W2119551073 @default.
- W4386988782 cites W2122522567 @default.
- W4386988782 cites W2123838232 @default.
- W4386988782 cites W2127063807 @default.
- W4386988782 cites W2137244437 @default.
- W4386988782 cites W2138030160 @default.
- W4386988782 cites W2138480916 @default.
- W4386988782 cites W2142461094 @default.
- W4386988782 cites W2147382256 @default.
- W4386988782 cites W2151864871 @default.
- W4386988782 cites W2152242630 @default.
- W4386988782 cites W2158106881 @default.
- W4386988782 cites W2168453644 @default.
- W4386988782 cites W2177380071 @default.
- W4386988782 cites W2179291431 @default.
- W4386988782 cites W2266996997 @default.
- W4386988782 cites W2269568465 @default.
- W4386988782 cites W2277403471 @default.
- W4386988782 cites W2296510841 @default.
- W4386988782 cites W2318437721 @default.
- W4386988782 cites W2322493859 @default.
- W4386988782 cites W2330108988 @default.
- W4386988782 cites W2394782024 @default.
- W4386988782 cites W2405985041 @default.
- W4386988782 cites W2415591826 @default.
- W4386988782 cites W2424165046 @default.
- W4386988782 cites W2503742534 @default.
- W4386988782 cites W2513174667 @default.
- W4386988782 cites W2530466621 @default.
- W4386988782 cites W2545125098 @default.
- W4386988782 cites W2560000662 @default.
- W4386988782 cites W2563195238 @default.
- W4386988782 cites W2564771875 @default.
- W4386988782 cites W2583180104 @default.
- W4386988782 cites W2590746002 @default.
- W4386988782 cites W2593816418 @default.